DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and LCK

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_001426075.1 Gene:LCK / 3932 HGNCID:6524 Length:567 Species:Homo sapiens


Alignment Length:408 Identity:135/408 - (33%)
Similarity:207/408 - (50%) Gaps:43/408 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   355 EELAKKSNQSQLSSTLTDDSRNSMVMQQWQ---GPVAFANRYVPWERDQQMG-IATSQLSTGVTN 415
            :.|::|..:.||.:  ..::..|.::::.:   |..:.:.|    :.||..| :........:.|
Human   188 KNLSRKDAERQLLA--PGNTHGSFLIRESESTAGSFSLSVR----DFDQNQGEVVKHYKIRNLDN 246

  Fly   416 GG-VSSPGVPSPGTGE---PGSNLGPGCLT--GGAGSSGAPENAFAGEANCDRWEFPRYRLKFFN 474
            || ..||.:..||..|   ..:|...|..|  .....:..|:..:..    |.||.||..||...
Human   247 GGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DEWEVPRETLKLVE 307

  Fly   475 ILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLG 539
            .||.|.||:||      :....|.|.||||:||:.:...|.  .|:|..:||.|: |..:|.|..
Human   308 RLGAGQFGEVW------MGYYNGHTKVAVKSLKQGSMSPDA--FLAEANLMKQLQ-HQRLVRLYA 363

  Fly   540 CCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSR 604
            ..| ::|.::|.||:..|.|..:|::....:           ||...|.....|:|:||.::..|
Human   364 VVT-QEPIYIITEYMENGSLVDFLKTPSGIK-----------LTINKLLDMAAQIAEGMAFIEER 416

  Fly   605 GIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSD 669
            ..|||||.|.|||::|..:||:||||.|| :|....|..:...|.||:|.|.|::....|::|||
Human   417 NYIHRDLRAANILVSDTLSCKIADFGLAR-LIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 480

  Fly   670 IWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLF 734
            :||||||:.||||.|..||||::..:|::.:..|||:.:|::|..|||.:|..||...|::||.|
Human   481 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTF 545

  Fly   735 AEIIQML-DKLLHTEMDY 751
            ..:..:| |....||..|
Human   546 DYLRSVLEDFFTATEGQY 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637
PTKc 474..742 CDD:270623 102/268 (38%)
LCKNP_001426075.1 None
Blue background indicates that the domain is not in the aligned region.

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