DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and KIT

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001372213.1	Gene:	KIT / 3815	HGNCID:	6342	Length:	977	Species:	Homo sapiens

Alignment Length:	375	Identity:	138/375 - (36%)
Similarity:	196/375 - (52%)	Gaps:	79/375 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMK 526
            :|||||.||.|...||.||||:|....|..:..::...|||||.||.||...:|:.|:|||:|:.
Human   582 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLS 646

  Fly   527 SLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLR-------SSRAERH-----YGN-THGK 578
            .|..|:|:|:|||.||...||.||.||...|.|..:||       .|:.|.|     |.| .|.|
Human   647 YLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSK 711

  Fly   579 SNVLTSC-----------------------------------------------------DLTSF 590
            .   :||                                                     ||.||
Human   712 E---SSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSF 773

  Fly   591 MYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMA 655
            .|||||||.:|.|:..|||||||||||:|.....|:.|||.|||:.....|..|...:||::|||
Human   774 SYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMA 838

  Fly   656 TESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNI 719
            .||:::.:::.:||:||:||.:||:.:|||:||||:.. :...:.:::|:|:..|||...|:|:|
Human   839 PESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDI 903

  Fly   720 MYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIVSLS 769
            |..||..||.:||.|.:|:|:::|         ::....:|.|.|:.:.|
Human   904 MKTCWDADPLKRPTFKQIVQLIEK---------QISESTNHIYSNLANCS 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	127/337 (38%)
		PTKc	474..742	CDD:270623	125/334 (37%)
KIT	NP_001372213.1	Ig strand A	212..215	CDD:409353
		ig	216..306	CDD:395002
		Ig strand B	229..239	CDD:409353
		Ig strand C'	250..252	CDD:409353
		Ig strand D	260..263	CDD:409353
		Ig strand E	267..280	CDD:409353
		Ig strand F	287..294	CDD:409353
		Ig strand G	300..308	CDD:409353
		IgI_4_SCFR	312..412	CDD:409446
		Ig strand B	332..336	CDD:409446
		Ig strand C	346..350	CDD:409446
		Ig strand E	376..380	CDD:409446
		Ig strand F	390..395	CDD:409446
		Ig strand G	403..406	CDD:409446
		Ig	427..503	CDD:409353
		Ig strand C	438..442	CDD:409353
		Ig strand E	471..479	CDD:409353
		Ig strand F	489..494	CDD:409353
		PTKc_Kit	554..929	CDD:270682	134/358 (37%)
		Important for interaction with phosphotyrosine-binding proteins	569..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810