DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and KDR

DIOPT Version :9

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:365 Identity:137/365 - (37%)
Similarity:199/365 - (54%) Gaps:67/365 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   457 EANCDR-------WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVD 514
            :.:|:|       |||||.|||....||.||||||...:|..|:......|||||.|||.||..:
Human   814 DEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 878

  Fly   515 RKDLLSELEVMKSLEPHINVVHLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSRAE--------- 569
            .:.|:|||:::..:..|:|||:|||.||.. .|..||:|:...|.|.|||||.|.|         
Human   879 HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGA 943

  Fly   570 -----RHY------------------------GNTHGKS---------------NVLTSCDLTSF 590
                 :.|                        |....||               :.||...|..:
Human   944 RFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICY 1008

  Fly   591 MYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMA 655
            .:||||||::|.||..|||||||||||:::.:..|:.|||.|||:.....|.||.:.:||::|||
Human  1009 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA 1073

  Fly   656 TESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNI 719
            .|:::|.:::::||:||||:|:|||.:||::||||:.. .:..|::::|.|:..|::...|:|..
Human  1074 PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQT 1138

  Fly   720 MYYCWSHDPQERPLFAEIIQMLDKLLHTE-----MDYIEL 754
            |..||..:|.:||.|:|:::.|..||...     .|||.|
Human  1139 MLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637
STYKc 470..741 CDD:214568 122/325 (38%)
PTKc 474..742 CDD:270623 120/322 (37%)
KDRNP_002244.1 Ig 41..109 CDD:299845
IG_like 231..324 CDD:214653
Ig1_VEGFR 239..326 CDD:143270
IG_like 340..417 CDD:214653
Ig2_VEGFR-2 348..417 CDD:143272
Ig_2 551..661 CDD:290606
IG 565..661 CDD:214652
I-set 667..754 CDD:254352
IGc2 680..744 CDD:197706
PTKc_VEGFR2 826..1167 CDD:270681 131/340 (39%)
Pkinase_Tyr 834..1160 CDD:285015 122/325 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4350
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.760

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