DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and KDR

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:365 Identity:137/365 - (37%)
Similarity:199/365 - (54%) Gaps:67/365 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   457 EANCDR-------WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVD 514
            :.:|:|       |||||.|||....||.||||||...:|..|:......|||||.|||.||..:
Human   814 DEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 878

  Fly   515 RKDLLSELEVMKSLEPHINVVHLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSRAE--------- 569
            .:.|:|||:::..:..|:|||:|||.||.. .|..||:|:...|.|.|||||.|.|         
Human   879 HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGA 943

  Fly   570 -----RHY------------------------GNTHGKS---------------NVLTSCDLTSF 590
                 :.|                        |....||               :.||...|..:
Human   944 RFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICY 1008

  Fly   591 MYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMA 655
            .:||||||::|.||..|||||||||||:::.:..|:.|||.|||:.....|.||.:.:||::|||
Human  1009 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA 1073

  Fly   656 TESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNI 719
            .|:::|.:::::||:||||:|:|||.:||::||||:.. .:..|::::|.|:..|::...|:|..
Human  1074 PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQT 1138

  Fly   720 MYYCWSHDPQERPLFAEIIQMLDKLLHTE-----MDYIEL 754
            |..||..:|.:||.|:|:::.|..||...     .|||.|
Human  1139 MLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637
PTKc 474..742 CDD:270623 120/322 (37%)
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448
Ig strand A 224..228 CDD:409448
Ig strand A' 234..238 CDD:409448
Ig strand B 240..249 CDD:409448
Ig strand C 256..261 CDD:409448
Ig strand C' 264..266 CDD:409448
Ig strand D 270..278 CDD:409448
Ig strand E 286..294 CDD:409448
Ig strand F 304..310 CDD:409448
Ig strand G 315..321 CDD:409448
IgI_VEGFR-2 329..417 CDD:409450
Ig strand A 329..332 CDD:409450
Ig strand A' 339..343 CDD:409450
Ig strand B 345..356 CDD:409450
Ig strand C 360..366 CDD:409450
Ig strand C' 368..371 CDD:409450
Ig strand D 376..379 CDD:409450
Ig strand E 381..386 CDD:409450
Ig strand F 394..402 CDD:409450
Ig strand G 408..417 CDD:409450
IG_like 565..661 CDD:214653
I-set 667..754 CDD:400151
Ig strand B 684..688 CDD:409353
Ig strand C 697..701 CDD:409353
Ig strand E 720..724 CDD:409353
Ig strand F 734..739 CDD:409353
VEGFR-2_TMD 759..793 CDD:375470
PTKc_VEGFR2 826..1167 CDD:270681 131/340 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
Blue background indicates that the domain is not in the aligned region.

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