DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and fgfr2

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_005169609.1	Gene:	fgfr2 / 352940	ZFINID:	ZDB-GENE-030323-1	Length:	836	Species:	Danio rerio

Alignment Length:	880	Identity:	246/880 - (27%)
Similarity:	368/880 - (41%)	Gaps:	261/880 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLLTIIVVTATVVSL--------ISQEAEAHNQNAPPILY------------------------- 58
            ||:|:..|:....||        ..:|....|||..|:|:
Zfish    35 LLMTLATVSVARPSLKIDLVNTSAPEEPPTKNQNCVPVLFSVHPGELLKLKCPLSGADDVVWTKD 99

  Fly    59 ----------VRERNW-RISE-TEK--------------------VGQIIDRVRAEDPD-----G 86
                      :..|:| :||: |.|                    :..:.|.:.:.|.:     .
Zfish   100 SSSLRPDNRTLVTRDWLQISDATPKDSGLYSCSATGSRDCDVFSFIVNVTDAISSGDDEDDTERS 164

  Fly    87 DDLIFGIEPRFSLPGGENDASP----PEKI----------------------------------P 113
            ||:  |.:       ||....|    |||:                                  |
Zfish   165 DDV--GAD-------GEQMRLPYWTFPEKMEKKLHAVPAANTVKFRCAAAGNPKPKMRWLKNAKP 220

  Fly   114 F-QIDRETGV-------VTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSSGYRP 170
            | |.||..|.       ..:.||:......|   |..:.:..|.:.|..:...:.||   |.:||
Zfish   221 FRQEDRMGGYKVRLQHWTLIMESVVPSDKGN---YTCLVENQYGSINHTYTLDVVER---SPHRP 279

  Fly   171 --QTSI-SNVVHNISQ---FLPRF--DQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNN 227
              |..: :||...:.|   |:.:.  |..|.:|             |.....:|        |:.
Zfish   280 ILQAGLPANVTVQVGQDAKFVCKVYSDAQPHIQ-------------WLQHYTKN--------GSR 323

  Fly   228 YPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPIT------ANNSTRVESA 286
            |  .|..:|.||..:|......|.||     :.:::.|.:...::|...      ||||..: ..
Zfish   324 Y--GPDGLPYVRVLKSSGINSSDVEV-----LMLTNVTEEDAGEITCKVSNYIGEANNSCWL-IV 380

  Fly   287 IPAETTTPSGGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKT 351
            |||| |.|....:......|.|:           .:|.|.:|..|::..:||.|..|     ||.
Zfish   381 IPAE-TNPIETDYPPDYVEIAIY-----------CIGVFLIACMVVIVVVCRMRTSA-----KKP 428

  Fly   352 KEKEELA--KKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVT 414
            ....:.|  |.:.|..|...::.||.:||                          ::|.....:|
Zfish   429 DFSSQPAVHKLTKQIPLRRQVSSDSSSSM--------------------------SSSTPLVRIT 467

  Fly   415 NGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEG 479
            ....|:...|.|                   ....||:        .||||.|.:|.....||||
Zfish   468 TRRSSAHDDPIP-------------------EYDLPED--------PRWEFSRDKLTLGKPLGEG 505

  Fly   480 AFGQVWRCEATNINGN--EGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCT 542
            .||||...||..|:.:  :...|||||.||:.|||.|..||:||:|:||.:..|.|:::|||.||
Zfish   506 CFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACT 570

  Fly   543 DKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSR 604
            ...|.:||:||.::|.|:.|||:.|   .|..|.........||..||.|..||||:||:||.|:
Zfish   571 QDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQ 635

  Fly   605 GIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSD 669
            ..|||||||||:|:|:.:..|:||||.||||.....|::.:.|:||::|||.|:|:|.:::.:||
Zfish   636 KCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 700

  Fly   670 IWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLF 734
            :||||:|||||.|||.:|||||...::.:.:::|:|::||.:|..|||.:|..||......||.|
Zfish   701 VWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTF 765

  Fly   735 AEIIQMLDKL--LHTEMDYIEL--------ERFPD 759
            .::::.||::  |.|..:|::|        ..|||
Zfish   766 KQLVEDLDRILTLATNEEYLDLCAPVEQYSPSFPD 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	29/170 (17%)
		STYKc	470..741	CDD:214568	127/275 (46%)
		PTKc	474..742	CDD:270623	126/272 (46%)
fgfr2	XP_005169609.1	Ig	71..148	CDD:299845	8/76 (11%)
		IG_like	75..148	CDD:214653	6/72 (8%)
		Ig2_FGFR	187..271	CDD:143265	12/86 (14%)
		IG_like	197..271	CDD:214653	12/76 (16%)
		IG_like	286..380	CDD:214653	25/122 (20%)
		Ig	294..381	CDD:299845	23/115 (20%)
		PTKc_FGFR2	471..783	CDD:270679	141/338 (42%)
		Pkinase_Tyr	496..772	CDD:285015	127/275 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.870