DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and Ddr

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	188/843 - (22%)
Similarity:	303/843 - (35%)	Gaps:	257/843 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VGQIIDRVRAEDPDGDDLIFGIEPRFSLPGGENDA--SPPEKIPFQIDRETGVVTLNESLAGRAG 134
            :||::|..|.:|....| |.|:...:...|..||.  ..|.:|.|:.:               ..
  Fly   303 LGQLVDGQRGKDNFRAD-INGLGKGYEWIGWRNDTLLGRPVEIIFEFE---------------TV 351

  Fly   135 QNFLIYITVTDGSYTAKNEVFINI-----LGERENSS-----GYRPQTSIS---NVVHNISQFLP 186
            :|....|..|:..::...:||::.     :|.|..|.     .|.|...:.   :|...:...|.
  Fly   352 RNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLG 416

  Fly   187 RFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDE 251
            |:.||....:.|          |. .:.:......|..||           ...|.:..|:|
  Fly   417 RYVQLHLYFAAR----------WM-MISEITFISAPVVGN-----------FTDELANGEKQ--- 456

  Fly   252 EVTPTTPVR-------ISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIF 309
            .||...|::       |||...:|:         ::|:|.|..|.:...|
  Fly   457 SVTSEYPLQRDEVGRAISSGGERSQ---------HTTQVISPKPIDHQEP--------------- 497

  Fly   310 SLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKE------------ELAKKSN 362
              ::..:.:::||.|  ..|.:|:|::    |..::|. |..:.:|            :....:.
  Fly   498 --ETSFVGVIITVLG--TIIMLLVAFI----LLIVARN-KHVRSRENGLDAFQHNFSPDTLNGNG 553

  Fly   363 QSQLSSTLTDD----SRNSMVMQQWQGPVAFANRY------------------------------ 393
            ..::.:|:.|:    .:||:..:.:.     ||.|
  Fly   554 VLKVVTTMDDNESSIDKNSLYHEPFN-----ANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQ 613

  Fly   394 ---VPWER-------------------------DQQMGIATSQLSTGVTNG------GVSSPGVP 424
               ||..:                         ..:..:||.:::....|.      .:.||.||
  Fly   614 DYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNSLNAATLPLPSPPVP 678

  Fly   425 SP---------------GTGEPGSNLGPGCLTGGAGSSGAPENAFAG------------------ 456
            .|               ....|||. ..|.|:....::..|.:...|
  Fly   679 PPLEKYYAATPVSSKPMPVAPPGSQ-SSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADI 742

  Fly   457 ---EANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDL 518
               .|||...||||..|.....||.|.||::..||...:|.    |.|||.||:..|.:..||:.
  Fly   743 NEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNA----TLVAVATLRPGANDHLRKEF 803

  Fly   519 LSELEVMKSL-EPHINVVHLLGCCTDKDPTFVILEYVN-RGKLQTYLRSSRAERHYGNTHG---K 578
            .|:.:.:..| :|  ||..|:|.|...:|..::.:|.: .|.|..:|     :.|...|.|   |
  Fly   804 RSKAKQLAQLSDP--NVARLVGACLRDEPICIVQDYSHCLGDLNQFL-----QEHVAETSGLMAK 861

  Fly   579 SNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFG-------FARDVI 636
            .::...| |.....|:|.||.:|.....:|||||.|:.:|..:...||...|       :|.|..
  Fly   862 KSLSFGC-LVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYC 925

  Fly   637 TSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLG-STPYPGISAADVMRKV 700
            ..:.:..:....:||||||.||:....|:.|||:|||.:.:|||:|.. ..||..:|...|:..:
  Fly   926 QLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENI 990

  Fly   701 RDGYR-------LEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDK-------LLHTEM 749
            ...||       |..|.:|.||:|::|..||..|...||.|.||...|.:       ..||.|
  Fly   991 GLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRKNLGFKPQTHTHM 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	21/98 (21%)
		STYKc	470..741	CDD:214568	94/290 (32%)
		PTKc	474..742	CDD:270623	93/287 (32%)
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572
		FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	99/298 (33%)
		TyrKc	759..1038	CDD:197581	94/290 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940