DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and sev

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	139/483 - (28%)
Similarity:	214/483 - (44%)	Gaps:	112/483 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 KSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRN 376
            |.|::.:.:......|:..||...|.|           |.:::...|||         |...||
  Fly  2122 KRGSLVLAIIAPAAIVSSCVLALVLVR-----------KVQKRRLRAKK---------LLQQSR- 2165

  Fly   377 SMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLT 441
                     |..::|......:.|.|.:.....||.:::..:
  Fly  2166 ---------PSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADI----------------------- 2198

  Fly   442 GGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTL 506
                       |...:.|   |.    :||....||.||||:|:..:....:..|. ..||:|:|
  Fly  2199 -----------ALLPQIN---WS----QLKLLRFLGSGAFGEVYEGQLKTEDSEEP-QRVAIKSL 2244

  Fly   507 KESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRA--E 569
            ::.|:|.  .:||.|.::|.:.: |.|:|.|:|.|.|.:...:|:|::..|.|.:|||::||  .
  Fly  2245 RKGASEF--AELLQEAQLMSNFK-HENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATST 2306

  Fly   570 RHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDD-------HTCKVA 627
            :....|.|    |:..:|.:....||.|..||.....:|||||.||.|:|:.       .|.|:.
  Fly  2307 QEPQPTAG----LSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIG 2367

  Fly   628 DFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGIS 692
            |||.|||:..|..|.::.||.||:|||:.|||.|.:|:.:||:|:||:|.|||:|||..||...:
  Fly  2368 DFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARN 2432

  Fly   693 AADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQML----DKLLHTEM---- 749
            ..:|:..|::|.||::|..|..:||:::..||..||.|||.|......|    ..|..|:|
  Fly  2433 NFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASAT 2497

  Fly   750 ----------------DYIELERFPDHN 761
                            |...||...:||
  Fly  2498 ADTVVSCSRPEFKVRFDGQPLEEHREHN 2525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	107/279 (38%)
		PTKc	474..742	CDD:270623	106/280 (38%)
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020
		Pkinase_Tyr	2209..2481	CDD:285015	107/279 (38%)
		PTKc_c-ros	2213..2483	CDD:270640	106/277 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455276
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940