DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and fgfr1a

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_694494.2 Gene:fgfr1a / 30705 ZFINID:ZDB-GENE-980526-255 Length:810 Species:Danio rerio


Alignment Length:566 Identity:184/566 - (32%)
Similarity:281/566 - (49%) Gaps:99/566 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 YPPPPPNIP-----GVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAI 287
            :..|.|:|.     .|.|.:.|.:..|......|..|   :||.|.    ..:....:..:|.| 
Zfish   269 FSDPQPHIQWLKHIEVNGSRYGPDGLPYVRALKTAGV---NTTDKE----MEVLQIRNVSLEDA- 325

  Fly   288 PAETTTPSGGH--HNNSSSPITIFSLKSGT-IP-------IVVTVGGFFVAIAVLLAYLCRRRLC 342
             .|.|..:|..  |::.|:.:|::.....| :|       ::..||.|.:.:.|..|.|.:....
Zfish   326 -GEYTCLAGNSIGHSHHSAWLTVYKAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAVLAKMHSS 389

  Fly   343 AISRTLKKTKEKEELA----KKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMG 403
            |     ||:....:||    .||...:...|::.||.:||                   ....|.
Zfish   390 A-----KKSDFNSQLAVHKLAKSIPLRRQVTVSVDSSSSM-------------------HSGGML 430

  Fly   404 IATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRY 468
            :..|:||:                :|.|        :..|......|::        .|||..|.
Zfish   431 VRPSRLSS----------------SGSP--------MLSGVSEYELPQD--------PRWEVQRD 463

  Fly   469 RLKFFNILGEGAFGQVWRCEATNINGNE--GITTVAVKTLKESATEVDRKDLLSELEVMKSLEPH 531
            ||.....||||.||||...||..::..:  .||.||||.||..|||.|..||:||:|:||.:..|
Zfish   464 RLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKH 528

  Fly   532 INVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQ 593
            .|:::|||.||...|.:||:|:..:|.|:.|||..|   .|..|.........::..||.|..||
Zfish   529 KNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQVPVENMSIKDLVSCAYQ 593

  Fly   594 VAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATES 658
            ||:||:||.|:..|||||||||:|:|:|:..|:||||.|||:.....|::.:.|:||::|||.|:
Zfish   594 VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEA 658

  Fly   659 LYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYC 723
            |:|.|::.:||:||||:|:|||.|||.:||||:...::.:.:::|:|:::|..|..|||.:|..|
Zfish   659 LFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDRPSTCTHELYMMMRDC 723

  Fly   724 WSHDPQERPLFAEIIQMLDKLLH--TEMDYIELE--------RFPD 759
            |...|.:||.|.::::.||:.|.  :..:|::|.        .|||
Zfish   724 WHAVPSQRPTFKQLVEDLDRTLSMTSNQEYLDLSVSLDQFSPNFPD 769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637
PTKc 474..742 CDD:270623 122/272 (45%)
fgfr1aNP_694494.2 Ig 28..116 CDD:472250
Ig strand B 49..53 CDD:409353
Ig strand C 61..65 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 96..101 CDD:409353
Ig strand G 109..112 CDD:409353
Ig 142..236 CDD:472250
Ig strand B 163..167 CDD:409353
Ig strand C 176..180 CDD:409353
Ig strand E 202..206 CDD:409353
Ig strand F 216..221 CDD:409353
Ig strand G 229..232 CDD:409353
Ig 244..347 CDD:472250 19/86 (22%)
Ig strand B 262..266 CDD:409353
Ig strand C 275..279 CDD:409353 1/3 (33%)
Ig strand E 313..317 CDD:409353 0/3 (0%)
Ig strand F 327..332 CDD:409353 2/4 (50%)
Ig strand G 340..343 CDD:409353 0/2 (0%)
PTKc_FGFR1 451..752 CDD:270678 132/308 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..810
Blue background indicates that the domain is not in the aligned region.

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