DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and kita

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_009292910.1	Gene:	kita / 30256	ZFINID:	ZDB-GENE-980526-464	Length:	981	Species:	Danio rerio

Alignment Length:	951	Identity:	231/951 - (24%)
Similarity:	356/951 - (37%)	Gaps:	349/951 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RRSLLLTIIVV--TATVVSLISQEAEAHNQN-----APPILYVRERNWRISETEKVGQIIDRVRA 81
            ||:::..|:..  ..||:..::.:.:..|.|     ..|:    ..:.|.|.:.:.|..:::||.
Zfish   117 RRTIVFDIVAAEGDTTVIPCLATDPDMKNLNLQKCDGQPL----PNSLRYSASLETGVSVEKVRK 177

  Fly    82 EDPDGDDLIFGIEPRFSLPGGE--------NDASPP--------------EKIPFQIDRETGVVT 124
            |. :|..:..|.....::..|.        .||.||              ||:  .:...|..|.
Zfish   178 EF-EGCYVCVGTLDAATVKSGRYQLTVRLVPDAPPPITLGQPQRVLLTQGEKL--SLSCSTSNVN 239

  Fly   125 LNESLAGRA--GQNFLIY----------------------ITVTD-GSYT--AKNE-------VF 155
            .:.::..:|  |.|..::                      :|:.| |:|:  |.||       |:
Zfish   240 SDIAVKWKAPNGVNPSVHQNSHLLTEPITHVRTAILSLSSVTMQDAGNYSCEAINEKGTTAKPVW 304

  Fly   156 INILGERENSSGYRPQTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGW-YPPVPQNN-- 217
            :||.     ..|:...||:.|....:     |..:...::.:.|..|......| |..|...|
Zfish   305 VNIY-----EKGFINITSVDNSTRRV-----RAGESLSLRVVMNAYPKPHTFSWSYSGVKLTNTT 359

  Fly   218 --IFGPPPFGNNYPP-------------------------------------------------- 230
              :......||:|..
Zfish   360 DHVITSRTHGNSYTSELKLVRLKVSESGIYTFSCLNRDATIRQTFEVHVISKPQIVSYEGPIDGQ 424

  Fly   231 --------PPPNI-------PGVRGEQSGEEEQPDEEVTPTTPVRISSTTP-------KSRTKLT 273
                    |.|.|       |..|........|.:|:|     |.::.|.|       :||..
Zfish   425 VRCVAEGYPTPQIKWYYCDLPHSRCSNLLNATQEEEDV-----VTVTMTNPPFGKGAVESRLN-- 482

  Fly   274 PITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGTIP----IVVTVGGFFVAIAVLLA 334
             ||.||...:|....|           |.....|:||:...|:|    ..:.:|  |||.||:|.
Zfish   483 -ITKNNYATLECVASA-----------NGEIVYTLFSISENTVPHELFTPLLIG--FVAAAVILV 533

  Fly   335 YLCRRRLCAISRTLK-KTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQW---QGPVAFANRYV- 394
                  |..|..|.| ..|.|.::                        ||   :|  ...|.||
Zfish   534 ------LILIVLTYKYMQKPKYQI------------------------QWKVIEG--IHGNNYVY 566

  Fly   395 ------PWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENA 453
                  |::.
Zfish   567 IDPTQLPYDH------------------------------------------------------- 576

  Fly   454 FAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDL 518
                    :|||||.:|:|...||.||||:|....|..::..:.:.|||||.||.||...:::.|
Zfish   577 --------QWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHATEKEAL 633

  Fly   519 LSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHY----------- 572
            :|||:|:..|..|||:|:|||.||...||.||.||...|.|..:||..|...:|
Zfish   634 MSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTLGEDAYYRN 698

  Fly   573 -----------------------------------GNTHGKSNVLTSC-----------DLTSFM 591
                                               |:::..|:.::..           ||.||.
Zfish   699 VMMQSEPNDSRNGYMTMKPSVLGILSSENRRSLNKGDSYSDSDAVSEILQEDGLTLDTEDLLSFS 763

  Fly   592 YQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMAT 656
            ||||||||:|.|:..|||||||||||:|.....|:.|||.|||:.|...|..|...:||::||:.
Zfish   764 YQVAKGMDFLASKNCIHRDLAARNILLTQGRVAKICDFGLARDITTDSNYVVKGNARLPVKWMSP 828

  Fly   657 ESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNIM 720
            ||:::.:::.:||:||:|||:|||.:|||:||||:.. :...:.:::|||:|.||....|:|:||
Zfish   829 ESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIM 893

  Fly   721 YYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIEL---ERFP 758
            :.||..||.:||.|::|::.:::.:.....:|.|   .|.|
Zfish   894 HSCWDADPVKRPSFSKIVEKIEQQISDSTKHIYLNFSSRLP 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	30/154 (19%)
		STYKc	470..741	CDD:214568	125/328 (38%)
		PTKc	474..742	CDD:270623	123/325 (38%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653	15/84 (18%)
		IG_like	218..307	CDD:214653	15/90 (17%)
		ig	218..297	CDD:278476	14/80 (18%)
		Ig	311..410	CDD:299845	14/103 (14%)
		IG_like	325..408	CDD:214653	10/87 (11%)
		PTKc_Kit	549..918	CDD:270682	137/457 (30%)
		Pkinase_Tyr	585..914	CDD:285015	125/328 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810