DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Kdr

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_037194.2	Gene:	Kdr / 25589	RGDID:	2965	Length:	1343	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	137/365 - (37%)
Similarity:	197/365 - (53%)	Gaps:	67/365 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 EANCDR-------WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVD 514
            :..|:|       |||||.|||....||.||||||...:|..|:......|||||.|||.||..:
  Rat   810 DERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSE 874

  Fly   515 RKDLLSELEVMKSLEPHINVVHLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSRAE--------- 569
            .:.|:|||:::..:..|:|||:|||.||.. .|..||:|:...|.|.||||..|.|
  Rat   875 HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGA 939

  Fly   570 -----RHY------------------------GNTHGKS---------------NVLTSCDLTSF 590
                 :.|                        |....||               :.||...|..:
  Rat   940 RFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICY 1004

  Fly   591 MYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMA 655
            .:||||||::|.||..|||||||||||:::.:..|:.|||.|||:.....|.||.:.:||::|||
  Rat  1005 SFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA 1069

  Fly   656 TESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNI 719
            .|:::|.:::::||:||||:|:|||.:||::||||:.. .:..|::::|.|:..|::...|:|..
  Rat  1070 PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQT 1134

  Fly   720 MYYCWSHDPQERPLFAEIIQMLDKLLHTE-----MDYIEL 754
            |..||..||.:||.|:|:::.|..||...     .|||.|
  Rat  1135 MLDCWHEDPNQRPAFSELVEHLGNLLQANAQQDGKDYIVL 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	122/325 (38%)
		PTKc	474..742	CDD:270623	120/322 (37%)
Kdr	NP_037194.2	Ig	224..325	CDD:416386
		Ig strand A	224..228	CDD:409353
		Ig strand A'	234..238	CDD:409353
		Ig strand B	240..249	CDD:409353
		Ig strand C	256..261	CDD:409353
		Ig strand C'	264..266	CDD:409353
		Ig strand D	270..278	CDD:409353
		Ig strand E	286..294	CDD:409353
		Ig strand F	304..310	CDD:409353
		Ig strand G	315..321	CDD:409353
		Ig	329..417	CDD:416386
		Ig strand A	329..332	CDD:409353
		Ig strand A'	339..343	CDD:409353
		Ig strand B	345..356	CDD:409353
		Ig strand C	360..366	CDD:409353
		Ig strand C'	368..371	CDD:409353
		Ig strand D	376..379	CDD:409353
		Ig strand E	381..386	CDD:409353
		Ig strand F	394..402	CDD:409353
		Ig strand G	408..417	CDD:409353
		Ig_3	547..641	CDD:404760
		IGc2	676..740	CDD:197706
		Ig strand B	680..684	CDD:409353
		Ig strand C	693..697	CDD:409353
		Ig strand E	716..720	CDD:409353
		Ig strand F	730..735	CDD:409353
		VEGFR-2_TMD	755..789	CDD:375470
		PTKc_VEGFR2	822..1163	CDD:270681	131/340 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1314
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810