DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Pdgfra

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_036934.1	Gene:	Pdgfra / 25267	RGDID:	3284	Length:	1088	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	135/413 - (32%)
Similarity:	201/413 - (48%)	Gaps:	102/413 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMK 526
            ||||||..|....|||.||||:|....|..::.::.:..||||.||.:|...:::.|:|||::|.
  Rat   584 RWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMT 648

  Fly   527 SLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYL---RSSRAERH----------YG----- 573
            .|.||:|:|:|||.||...|.::|.||...|.|..||   |.|...||          :|
  Rat   649 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSRHPEKPKKDLDIFGLNPAD 713

  Fly   574 ------------------------------------------------------------NTHGK 578
                                                                        ::..|
  Rat   714 ESTRSYVILSFENNGDYVDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAK 778

  Fly   579 -------SNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVI 636
                   |..||..||.||.||||:||::|.|:..:||||||||:|:......|:.|||.|||::
  Rat   779 NLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIM 843

  Fly   637 TSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKV 700
            ....|..|....||::|||.||::||:::..||:||:|:|:|||.:||.|||||:.. :....|:
  Rat   844 HDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKI 908

  Fly   701 RDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLL---------HTEMDYIELE- 755
            :.|||:.||:|...|:|.||..||:.:|::||.|..:.::::.||         ...:|:::.:
  Rat   909 KSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDH 973

  Fly   756 ------RFPDHNYYNIVSLSGEK 772
                  |....|.|..|:...|:
  Rat   974 PAVARMRVDSDNAYIGVTYKNEE 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	121/356 (34%)
		PTKc	474..742	CDD:270623	120/353 (34%)
Pdgfra	NP_036934.1	Ig_3	27..99	CDD:404760
		Ig	211..309	CDD:416386
		Ig strand A	211..215	CDD:409353
		Ig strand A'	222..226	CDD:409353
		Ig strand B	228..237	CDD:409353
		Ig strand C	242..247	CDD:409353
		Ig strand C'	250..252	CDD:409353
		Ig strand D	256..264	CDD:409353
		Ig strand E	268..276	CDD:409353
		Ig strand F	286..292	CDD:409353
		Ig strand G	297..303	CDD:409353
		Ig4_PDGFR	312..412	CDD:409445
		Ig strand B	332..336	CDD:409445
		Ig strand C	345..349	CDD:409445
		Ig strand E	376..380	CDD:409445
		Ig strand F	390..395	CDD:409445
		Ig strand G	403..406	CDD:409445
		PTKc_PDGFR_alpha	554..955	CDD:173653	129/370 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910