DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_113713.1	Gene:	Pdgfrb / 24629	RGDID:	3285	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	947	Identity:	219/947 - (23%)
Similarity:	333/947 - (35%)	Gaps:	336/947 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDP-------DGDDLIFGI------------- 93
            :|.:..|.|..|:|.:              :...||       |.:||...:
  Rat   101 YNNSLGPELSERKRIY--------------IFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVT 151

  Fly    94 EPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFINI 158
            :|:..:...|.....|..:|:  |.:.|.:.                 |..|.:|..|..:
  Rat   152 DPQLEVTLHEKKVDIPLHVPY--DHQRGFIG-----------------TFEDKTYICKTTI---- 193

  Fly   159 LGERENSSG----YRPQTSISNVVHNISQFLPRFDQLPGVQSIRNG---------LPNSRPGGWY 210
             |:||..|.    |..|.|..||..|..|.:.|..:...::.|..|         .|..:.|...
  Rat   194 -GDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLV 257

  Fly   211 PPVPQNNIFG-PPPFGNNYPPPPPNIP---------GVRGEQSGEEEQPDEEVTPTTPVRISSTT 265
            .|| .:.:|| |...|:....|...:.         .|.....|:|:..:..|.....||:..|.
  Rat   258 EPV-TDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINVTVIENGYVRLLETL 321

  Fly   266 P--------KSRTKLTPITA----------NNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLK 312
            .        :|||......|          :|.|..:|:......:..........|.:|:..:|
  Rat   322 EDVQIAELHRSRTLQVVFEAYPTPSVLWFKDNRTLGDSSAGELVLSTRNVSETRYVSELTLVRVK 386

  Fly   313 SGTIPIVVTVGGFFVAIA------VLLAY-------------------------LCRRR------ 340
                   |:..|::...|      |.|::                         .||.|
  Rat   387 -------VSEAGYYTMRAFHADDQVQLSFKLQVNVPVRVLELSESHPANGEQILRCRGRGMPQPN 444

  Fly   341 -LCAISRTLKKTKEKEELAKKSN----QSQLSSTLT---DDSRNSMV-----------------M 380
             ..:..|.||:...|.......|    :|||.:.:|   :|....:|                 :
  Rat   445 VTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCML 509

  Fly   381 QQWQGPVAFANRYVP------------------------------WERDQQMGIATSQLSTGVTN 415
            |...|..:.....||                              |:|..:..|....:.:
  Rat   510 QNSMGRDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQRKPRYEIRWKVIES---- 570

  Fly   416 GGVSSPG----------VPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRL 470
              |||.|          :|...|                                  ||.||.:|
  Rat   571 --VSSDGHEYIYVDPVQLPYDST----------------------------------WELPRDQL 599

  Fly   471 KFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVV 535
            .....||.||||||....|..::.::....||||.||.:|...:::.|:|||::|..|.||:|||
  Rat   600 VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVV 664

  Fly   536 HLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERH-----------YGN---------TH- 576
            :|||.||...|.::|.||...|.|..||..::   .:||           |.|         :|
  Rat   665 NLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSTELYSNALPVGLSLPSHL 729

  Fly   577 ---GKSN---------------------------------------------------------- 580
               |:|:
  Rat   730 NLTGESDGGYMDMSKDESVDYVPMLDMKGHIKYADIESSSYMAPYDNYVPSAPERTYRATLINDS 794

  Fly   581 -VLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERK 644
             ||:..||..|.||||.||::|.|:..:||||||||:||.:....|:.|||.|||::....|..|
  Rat   795 PVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK 859

  Fly   645 SEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAAD-VMRKVRDGYRLEK 708
            ....||::|||.||:::::::..||:||||||:|||.|||.||||.:...| ....::.|||:.:
  Rat   860 GSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQ 924

  Fly   709 PEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLL 745
            |.|...|:|.||..||....:.||.|::::.:|::||
  Rat   925 PAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLL 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	17/118 (14%)
		STYKc	470..741	CDD:214568	120/357 (34%)
		PTKc	474..742	CDD:270623	119/354 (34%)
Pdgfrb	NP_113713.1	ig	36..113	CDD:395002	3/11 (27%)
		Ig strand B	49..53	CDD:409353
		Ig strand C	59..62	CDD:409353
		Ig strand E	82..86	CDD:409353
		Ig strand F	96..101	CDD:409353	219/947 (23%)
		Ig	211..309	CDD:416386	20/98 (20%)
		Ig strand A	211..215	CDD:409353	1/3 (33%)
		Ig strand A'	222..226	CDD:409353	0/3 (0%)
		Ig strand B	228..237	CDD:409353	1/8 (13%)
		Ig strand C	242..247	CDD:409353	0/4 (0%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	256..264	CDD:409353	2/8 (25%)
		Ig strand E	270..277	CDD:409353	1/6 (17%)
		Ig strand F	287..293	CDD:409353	0/5 (0%)
		Ig strand G	298..304	CDD:409353	2/5 (40%)
		Ig	313..414	CDD:416386	18/107 (17%)
		PKc_like	561..952	CDD:419665	131/430 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1097
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010