DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and ros1

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_009291185.1	Gene:	ros1 / 245951	ZFINID:	ZDB-GENE-020506-1	Length:	1443	Species:	Danio rerio

Alignment Length:	710	Identity:	190/710 - (26%)
Similarity:	279/710 - (39%)	Gaps:	178/710 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSS---GYRPQ 171
            :|:.....:|...|||| .:.|.      :|..|.|||..  |...:||.|:|...|   .:...
Zfish   773 DKLSVFSGKEVAGVTLN-MIEGN------LYWLVQDGSLL--NLYRVNISGDRMQKSKAVEFAKW 828

  Fly   172 TSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNN------------------I 218
            |:.....|.:|.:..|...|...:.:|           ...:.|||                  :
Zfish   829 TTSQIFDHQVSYYSERLVWLDENKQLR-----------IQELNQNNSVLMSSNNTLTAFSVVQKM 882

  Fly   219 FGPPPFGNNYPPP--PPNI-----------------PG----------VRGEQSGEEEQPDEEVT 254
            ..|.|.|...||.  ||.:                 |.          |..::..:...|...:.
Zfish   883 LKPLPDGFVSPPVVIPPAVSKIVLVGNASFFQIHWEPSSVDYGTVFYCVVSKEVWKNLDPLPNMF 947

  Fly   255 PTT---PVRISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGT- 315
            ||.   ||...:.|..:.|:..|....|.          |.||. .:.....|..||....:||
Zfish   948 PTRYCHPVNTFTETVINVTRFKPGAELNI----------TITPF-SYWGKGKSTETILITPAGTS 1001

  Fly   316 -------IPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDD 373
                   |.||....|..:.|.:|...:.:|.         ..|:....||:.:..|:...:
Zfish  1002 DTDKTLIIAIVSVAVGVTLIILILAVVIWQRH---------HKKKDHGKAKQPSSVQIHPDV--- 1054

  Fly   374 SRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPG 438
                                   |.:...|:      .|:.||..:....||
Zfish  1055 -----------------------ELEYVRGL------VGLENGCFAISNTPS------------- 1077

  Fly   439 CLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWR--CEATNINGNEGITTV 501
                .|.....|             .|||..||...:||.||||:|:.  ...:.|||.|....|
Zfish  1078 ----RAEIESLP-------------VFPRDCLKLQRLLGSGAFGEVYEGVTVGSQINGVEPERKV 1125

  Fly   502 AVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSS 566
            |:|||::.|::.::.:.|.|..:|.... |.|::.|||.|...:|.::|||.:..|.|::|||.:
Zfish  1126 AIKTLQKDASDYEKTEFLKEAHLMSQFN-HPNILRLLGVCLLNEPHYLILELMEGGDLRSYLRGA 1189

  Fly   567 RAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILI-----TD-DHTCK 625
            |.      |:....:|:...|.......|.|..||.....:|||:||||.|:     || :...|
Zfish  1190 RP------TNNHKELLSLSSLLDISLDAATGCAYLERMHFVHRDIAARNCLVSVRTYTDPERVVK 1248

  Fly   626 VADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPG 690
            :.|||.||||..:..|.:|.||.||:|||:.|||.|.||:..||:|:||:|:|||:|||..|||.
Zfish  1249 IGDFGLARDVYKNDYYRKKGEGLLPVRWMSPESLTDGIFNKYSDVWAFGVLLWEILTLGKLPYPT 1313

  Fly   691 ISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMD 750
            .:..:|:..:..|.||..|..|.:.|||:|..|||..|.:||.|..:.:.:.||.:.|.|
Zfish  1314 YTNHEVLSYISTGGRLSSPAGCPQRLYNLMMSCWSKQPADRPNFQFLEETMRKLRNYEAD 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	17/53 (32%)
		STYKc	470..741	CDD:214568	110/278 (40%)
		PTKc	474..742	CDD:270623	108/275 (39%)
ros1	XP_009291185.1	FN3	70..151	CDD:238020
		FN3	156..244	CDD:238020
		FN3	525..618	CDD:238020
		Pkinase_Tyr	1092..1362	CDD:285015	110/276 (40%)
		PKc_like	1096..1364	CDD:304357	108/274 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910