DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and FLT4

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:XP_011532780.1 Gene:FLT4 / 2324 HGNCID:3767 Length:1440 Species:Homo sapiens


Alignment Length:874 Identity:221/874 - (25%)
Similarity:346/874 - (39%) Gaps:262/874 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 GDDLIFGIEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTD---GS 147
            ||:|:       .||.......|||   ||..::      .::|:||...:.|:...||:   |:
Human   425 GDELV-------KLPVKLAAYPPPE---FQWYKD------GKALSGRHSPHALVLKEVTEASTGT 473

  Fly   148 YTAKNEVFINILGERENSSGYRPQTSISNVVHNISQFLPRFDQLPGVQSIRN-----------GL 201
            ||         |....:::|.|...|:..||:...|...:....|.:.|..:           .|
Human   474 YT---------LALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPL 529

  Fly   202 PNSRPGGWYPPVP-------------QNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEV 253
            |.|....|.|..|             |.::.             |.....|...:.:...|.|.:
Human   530 PLSIQWHWRPWTPCKMFAQRSLRRRQQQDLM-------------PQCRDWRAVTTQDAVNPIESL 581

  Fly   254 TPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAE------------TTTPSGGHHNNSSS-- 304
            ...|  .......|:.:||....||.|...:..:..:            ||.|.|....:..|  
Human   582 DTWT--EFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEE 644

  Fly   305 -----PITI--------------FSLKSGTI------PIVVTVGGFFVAIAVLLAYL------CR 338
                 |:.:              :.|...|:      |:::......:....|.|.|      .|
Human   645 LLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGAR 709

  Fly   339 RRLCAIS-------------------RTLKKTKEKEELAKKSNQS-QLSSTLTD---DSRNSMVM 380
            ....::|                   |:..|...|:.|:.::.:: :|:..|||   :..:|:.|
Human   710 HATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 774

  Fly   381 QQWQGPVAFANRYVP---WERDQQM-----GI----ATSQLS-------------------TGVT 414
            |     ...|..:.|   |.:|:::     |:    :..:||                   .|..
Human   775 Q-----CLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCV 834

  Fly   415 NGGVSSPGVPSPGTGEPGSN-----LGPGCL------------------------TG------GA 444
            |   ||..|...|:.:.||.     :|.|.:                        ||      ..
Human   835 N---SSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDP 896

  Fly   445 GSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKES 509
            |.....|.......:..:|||||.||....:||.||||:|....|..|:......|||||.|||.
Human   897 GEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEG 961

  Fly   510 ATEVDRKDLLSELEVMKSLEPHINVVHLLGCCT-DKDPTFVILEYVNRGKLQTYLRSSR------ 567
            ||..:.:.|:|||:::..:..|:|||:|||.|| .:.|..||:|:...|.|..:||:.|      
Human   962 ATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPC 1026

  Fly   568 AER-------------------------------HYGNTHGKS--------------NVLTSCDL 587
            ||:                               .:..|.|.:              :.||..||
Human  1027 AEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDL 1091

  Fly   588 TSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIR 652
            ..:.:|||:||::|.||..|||||||||||:::....|:.|||.|||:.....|.||...:||::
Human  1092 VCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLK 1156

  Fly   653 WMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRREL 716
            |||.||::|.:::.:||:||||:|:|||.:||::||||:.. .:..:::|||.|:..||.....:
Human  1157 WMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAI 1221

  Fly   717 YNIMYYCWSHDPQERPLFAEIIQMLDKLL 745
            ..||..|||.||:.||.|:|::::|..||
Human  1222 RRIMLNCWSGDPKARPAFSELVEILGDLL 1250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 20/80 (25%)
PTKc 474..742 CDD:270623 119/320 (37%)
FLT4XP_011532780.1 Ig_2 214..301 CDD:464026
IgI_VEGFR 307..406 CDD:409448
Ig strand A 307..311 CDD:409448
Ig strand A' 317..321 CDD:409448
Ig strand B 323..332 CDD:409448
Ig strand C 339..344 CDD:409448
Ig strand C' 347..349 CDD:409448
Ig strand D 353..361 CDD:409448
Ig strand E 366..374 CDD:409448
Ig strand F 384..390 CDD:409448
Ig strand G 395..401 CDD:409448
IgI_VEGFR-3 408..495 CDD:409449 23/94 (24%)
Ig strand A 409..414 CDD:409449
Ig strand A' 419..424 CDD:409449
Ig strand B 426..437 CDD:409449 4/17 (24%)
Ig strand C 441..447 CDD:409449 4/8 (50%)
Ig strand C' 449..452 CDD:409449 0/2 (0%)
Ig strand D 455..457 CDD:409449 1/1 (100%)
Ig strand E 459..464 CDD:409449 1/4 (25%)
Ig strand F 472..480 CDD:409449 4/16 (25%)
Ig strand G 486..495 CDD:409449 2/8 (25%)
Ig_3 636..732 CDD:464046 10/95 (11%)
Ig 755..842 CDD:472250 19/94 (20%)
Ig strand B 772..776 CDD:409353 2/8 (25%)
Ig strand C 785..789 CDD:409353 0/3 (0%)
Ig strand E 808..812 CDD:409353 1/3 (33%)
Ig strand F 822..827 CDD:409353 0/4 (0%)
VEGFR-2_TMD 847..881 CDD:375470 4/33 (12%)
PTKc_VEGFR3 914..1253 CDD:270680 129/337 (38%)
Blue background indicates that the domain is not in the aligned region.

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