DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and FLT1

DIOPT Version :9

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_002010.2 Gene:FLT1 / 2321 HGNCID:3763 Length:1338 Species:Homo sapiens


Alignment Length:744 Identity:209/744 - (28%)
Similarity:300/744 - (40%) Gaps:231/744 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 SNVVHNISQFLPRFDQLPGVQSIRNGL--PNSRPGGWYPPVPQNNIFGPPPFGNN---YPPPPPN 234
            ||:.:.|.....|...:.|...:.:.|  .:||..|.|..:..|.:   ...|.|   |....||
Human   496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV---GTVGRNISFYITDVPN 557

  Fly   235 IPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPK----SRTKLTPITANNSTRVESAIPAETTTPS 295
                 |.....|:.|    |....:::|.|..|    ..|.:...|.||.|.             
Human   558 -----GFHVNLEKMP----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM------------- 600

  Fly   296 GGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKK 360
              |::.|...:.|  .|..:|.:.:|:  ..|::.....|.||.|         .....||:.:|
Human   601 --HYSISKQKMAI--TKEHSITLNLTI--MNVSLQDSGTYACRAR---------NVYTGEEILQK 650

  Fly   361 SNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPS 425
                           ..:.::..:.|....|.     .|..:.|::|      |.....:.|||.
Human   651 ---------------KEITIRDQEAPYLLRNL-----SDHTVAISSS------TTLDCHANGVPE 689

  Fly   426 PG----------TGEPGSNLGPGCLT----------------------GGAGSSG---------- 448
            |.          ..|||..||||..|                      |...||.          
Human   690 PQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDK 754

  Fly   449 ---------------------------------------------APENAFAGEANCDR------ 462
                                                         .|:.....| .|:|      
Human   755 SNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDE-QCERLPYDAS 818

  Fly   463 -WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMK 526
             |||.|.|||....||.||||:|.:..|..|..:....|||||.|||.||..:.|.|::||:::.
Human   819 KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILT 883

  Fly   527 SLEPHINVVHLLGCCTDK-DPTFVILEYVNRGKLQTYLRSSR--------AERHY---------G 573
            .:..|:|||:|||.||.: .|..||:||...|.|..||:|.|        |..|.         |
Human   884 HIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPG 948

  Fly   574 NTHGK------------------------SNV-------------LTSCDLTSFMYQVAKGMDYL 601
            ...||                        |:|             :|..||.|:.:|||:||::|
Human   949 LEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFL 1013

  Fly   602 TSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSV 666
            :||..|||||||||||:::::..|:.|||.|||:..:..|.||.:.:||::|||.||::|.|:|.
Human  1014 SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYST 1078

  Fly   667 KSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQE 730
            |||:||:|:|:|||.:||.:||||:.. .|...::|:|.|:..||:...|:|.||..||..||:|
Human  1079 KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKE 1143

  Fly   731 RPLFAEIIQMLDKLLHTEM-----DYIEL 754
            ||.|||:::.|..||...:     |||.:
Human  1144 RPRFAELVEKLGDLLQANVQQDGKDYIPI 1172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637
STYKc 470..741 CDD:214568 131/326 (40%)
PTKc 474..742 CDD:270623 129/323 (40%)
FLT1NP_002010.2 IG_like 143..219 CDD:214653
IG_like 237..328 CDD:214653
Ig1_VEGFR_like 245..327 CDD:143219
Ig2_VEGFR-1 353..424 CDD:143326
IG 568..640 CDD:214652 20/99 (20%)
IGc2 569..640 CDD:197706 19/98 (19%)
I-set 661..748 CDD:254352 21/97 (22%)
IGc2 676..738 CDD:197706 14/67 (21%)
PTKc_VEGFR1 819..1157 CDD:271109 137/337 (41%)
Pkinase_Tyr 827..1154 CDD:285015 131/326 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..982 5/41 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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