DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and FGFR4

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001341913.1	Gene:	FGFR4 / 2264	HGNCID:	3691	Length:	802	Species:	Homo sapiens

Alignment Length:	664	Identity:	200/664 - (30%)
Similarity:	297/664 - (44%)	Gaps:	148/664 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SIRNGLPNSRPGGWYP--------PVPQNNI--FGPPPFGNNYPPPPPNIPGVRGEQS--GEEEQ 248
            |.|:..|...|...:|        .||..|.  |..|..||    |.|.|..::..|:  ||..
Human   137 SNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGN----PTPTIRWLKDGQAFHGENR- 196

  Fly   249 PDEEVTPTTPVRI---------SSTTPKSRTKLTPITAN--NSTR----------------VESA 286
                   ...:|:         .|..|..|...|.:..|  .|.|                :::.
Human   197 -------IGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAG 254

  Fly   287 IPAETTTPSGGHHNNSSSPITIFSLKSGTIP-------IVVTVGGF----FVAIAVL-------- 332
            :||.||...|      |....:..:.|...|       ||:....|    |..:.||
Human   255 LPANTTAVVG------SDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSS 313

  Fly   333 ---LAYL-------CRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPV 387
               :.||       .....|....::..:.:...|.....:....:....::|.:.::....|.:
Human   314 EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSL 378

  Fly   388 AFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSP---------------------GTGEP 431
            |               :|...|..|:..|.......|.|                     .:|:.
Human   379 A---------------LAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKS 428

  Fly   432 GSNLGPGCLTGGAGSSGAPENAFAGEANCD-----RWEFPRYRLKFFNILGEGAFGQVWRCEATN 491
            .|:|..|.....:|.:     ..||..:.|     .|||||.||.....||||.||||.|.||..
Human   429 SSSLVRGVRLSSSGPA-----LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFG 488

  Fly   492 IN--GNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYV 554
            ::  ..:..:|||||.||::|::.|..||:||:||||.:..|.|:::|||.||.:.|.:||:|..
Human   489 MDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA 553

  Fly   555 NRGKLQTYLRSSRAERHYGNTHGKSN--------VLTSCDLTSFMYQVAKGMDYLTSRGIIHRDL 611
            .:|.|:.:||:.|......:..|..:        ||.||     .||||:||.||.||..|||||
Human   554 AKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC-----AYQVARGMQYLESRKCIHRDL 613

  Fly   612 AARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGIL 676
            ||||:|:|:|:..|:||||.||.|.....|::.|.|:||::|||.|:|:|.:::.:||:||||||
Human   614 AARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGIL 678

  Fly   677 MWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQML 741
            :|||.|||.:|||||...::...:|:|:|:::|.||..|||.:|..||...|.:||.|.::::.|
Human   679 LWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743

  Fly   742 DK-LLHTEMDYIEL 754
            || ||....:|::|
Human   744 DKVLLAVSEEYLDL 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	126/280 (45%)
		PTKc	474..742	CDD:270623	125/277 (45%)
FGFR4	NP_001341913.1	IGc2	50..107	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..148		3/10 (30%)
		Ig	157..241	CDD:325142	21/95 (22%)
		Ig3_FGFR-2	264..351	CDD:143266	14/92 (15%)
		PKc_like	454..767	CDD:328722	139/309 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770