DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and FGFR2

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_075259.4 Gene:FGFR2 / 2263 HGNCID:3689 Length:822 Species:Homo sapiens


Alignment Length:832 Identity:226/832 - (27%)
Similarity:349/832 - (41%) Gaps:235/832 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 PRFSLPGGENDASPPEKIP--FQIDR-ETGVVTLNESLAGRAGQNFLIYITVT-DGSYTAKNEVF 155
            |.|||.  |:....||:.|  :||.: |..|....|||..|........|:.| ||.:...|...
Human    23 PSFSLV--EDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRT 85

  Fly   156 INILGERENSSGYRPQTS------------------ISNVVHNISQFLPRFDQLPGVQSIRNGLP 202
            : ::||.....|..|:.|                  :.||...||......|.......:.....
Human    86 V-LIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSN 149

  Fly   203 NSRPGGW---------YPPVPQNNI--FGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEV--- 253
            |.|...|         ...||..|.  |..|..||       .:|.:|..::|:|.:.:..:   
Human   150 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGN-------PMPTMRWLKNGKEFKQEHRIGGY 207

  Fly   254 ---TPTTPVRISSTTPKSRTKLTPITAN-----NSTR-------------VESAIPAETTTPSGG 297
               .....:.:.|..|..:...|.:..|     |.|.             :::.:||..:|..||
Human   208 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 272

  Fly   298 -----------------------------------------HHNNSSSPITIFSLKSGT------ 315
                                                     |...:||...:.:|.:.|      
Human   273 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGE 337

  Fly   316 --------------------IP--------------------IVVTVGGFFVAIAVLLAYLCRRR 340
                                :|                    .:..:|.|.:|..|:...|||  
Human   338 YICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR-- 400

  Fly   341 LCAISRTLKKTKEKEELAKKSNQSQLSS--------TLTDDSRNSMVMQQWQGPVAFANRYVPWE 397
                   :|.|.:|.:.:.:....:|:.        |::.:|.:||            |...|..
Human   401 -------MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM------------NSNTPLV 446

  Fly   398 RDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDR 462
            |      .|::||        |:...|               :..|......||:        .:
Human   447 R------ITTRLS--------STADTP---------------MLAGVSEYELPED--------PK 474

  Fly   463 WEFPRYRLKFFNILGEGAFGQVWRCEATNINGN--EGITTVAVKTLKESATEVDRKDLLSELEVM 525
            |||||.:|.....||||.||||...||..|:.:  :...|||||.||:.|||.|..||:||:|:|
Human   475 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 539

  Fly   526 KSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDL 587
            |.:..|.|:::|||.||...|.:||:||.::|.|:.|||:.|   .|..|.........:|..||
Human   540 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDL 604

  Fly   588 TSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIR 652
            .|..||:|:||:||.|:..|||||||||:|:|:::..|:||||.|||:.....|::.:.|:||::
Human   605 VSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVK 669

  Fly   653 WMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELY 717
            |||.|:|:|.:::.:||:||||:|||||.|||.:|||||...::.:.:::|:|::||.:|..|||
Human   670 WMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELY 734

  Fly   718 NIMYYCWSHDPQERPLFAEIIQMLDKL--LHTEMDYIELER--------FPD 759
            .:|..||...|.:||.|.::::.||::  |.|..:|::|.:        :||
Human   735 MMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPD 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 23/72 (32%)
PTKc 474..742 CDD:270623 124/272 (46%)
FGFR2NP_075259.4 IgI_1_FGFR 31..124 CDD:409362 21/93 (23%)
Ig strand A 31..34 CDD:409362 0/2 (0%)
Ig strand A' 47..53 CDD:409362 2/5 (40%)
Ig strand B 56..66 CDD:409362 4/9 (44%)
Ig strand C 69..74 CDD:409362 1/4 (25%)
Ig strand C' 77..79 CDD:409362 0/1 (0%)
Ig strand D 84..88 CDD:409362 0/4 (0%)
Ig strand E 91..96 CDD:409362 0/4 (0%)
Ig strand F 102..111 CDD:409362 1/8 (13%)
Ig strand G 114..124 CDD:409362 0/9 (0%)
IgI_2_FGFR 154..248 CDD:409443 18/100 (18%)
Ig strand A 154..157 CDD:409443 0/2 (0%)
Ig strand A' 165..170 CDD:409443 0/4 (0%)
Ig strand B 174..182 CDD:409443 2/7 (29%)
Ig strand C 188..193 CDD:409443 1/4 (25%)
Ig strand C' 196..198 CDD:409443 0/1 (0%)
Ig strand D 207..210 CDD:409443 0/2 (0%)
Ig strand E 214..219 CDD:409443 0/4 (0%)
Ig strand F 228..235 CDD:409443 1/6 (17%)
Ig strand G 238..248 CDD:409443 2/9 (22%)
Ig 256..358 CDD:472250 10/101 (10%)
Ig strand B 274..278 CDD:409353 0/3 (0%)
Ig strand C 287..291 CDD:409353 0/3 (0%)
Ig strand E 323..327 CDD:409353 0/3 (0%)
Ig strand F 337..342 CDD:409353 0/4 (0%)
Ig strand G 350..353 CDD:409353 0/2 (0%)
PTKc_FGFR2 457..769 CDD:270679 138/334 (41%)

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