DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and FGFR3

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_006713931.1	Gene:	FGFR3 / 2261	HGNCID:	3690	Length:	811	Species:	Homo sapiens

Alignment Length:	801	Identity:	228/801 - (28%)
Similarity:	343/801 - (42%)	Gaps:	172/801 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SETEKVGQIIDRVRAEDPDGDDLIFG----IEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNE 127
            :|...||:..:....|....:.|:||    :|.....|||     .|......:...||:|....
Human    27 TEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGG-----GPMGPTVWVKDGTGLVPSER 86

  Fly   128 SLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSSGYRPQTSISNVVHNISQFLPRFDQLP 192
            .|.|..      .:.|.:.|:              |:|..|..:..::..|  :..|..|....|
Human    87 VLVGPQ------RLQVLNASH--------------EDSGAYSCRQRLTQRV--LCHFSVRVTDAP 129

  Fly   193 GVQSIRNGLPNSRPGG-------WYPP---------VPQNNI--FGPPPFGNNYPPPPPNIPGVR 239
            ......:|...:...|       |..|         ||..|.  |..|..||    |.|:|..::
Human   130 SSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGN----PTPSISWLK 190

  Fly   240 GEQSGEEEQPDEEV------TPTTPVRISSTTPKSRTKLTPITAN--NSTR-------------- 282
               :|.|.:.:..:      .....:.:.|..|..|...|.:..|  .|.|
Human   191 ---NGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHR 252

  Fly   283 --VESAIPAETTTPSGGHHNNSSSPITIFSLK--SGTIPIV-----VTVGGFFVA------IAVL 332
              :::.:||..|...|..        ..|..|  |...|.:     |.|.|..|.      :.||
Human   253 PILQAGLPANQTAVLGSD--------VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL 309

  Fly   333 LAYLCRRRLCAISRTLKKTKEK---EELAKKSNQSQLSSTLTDDSRNSMVMQQW---QGPVAFAN 391
            .:::.......:...|....|:   |.|.:.:|...::....           |   .||.|...
Human   310 KSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAF-----------WLSVHGPRAAEE 363

  Fly   392 RYVPWERDQQMGIATSQLSTG------------VTNGGVSSPGVPSPGTGEP------------- 431
            ..|  |.|:...:....||.|            ||...:.||  |..|.|.|
Human   364 ELV--EADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSP--PKKGLGSPTVHKISRFPLKRQ 424

  Fly   432 -----GSNLGPGC---------LTGGAGSSGAPENAFAGEANCD-RWEFPRYRLKFFNILGEGAF 481
                 .||.....         |:.|.|.:.|  |....|...| :||..|.||.....||||.|
Human   425 VTVSLESNASMSSNTPLVRIARLSSGEGPTLA--NVSELELPADPKWELSRARLTLGKPLGEGCF 487

  Fly   482 GQVWRCEATNINGNEGI--TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDK 544
            |||...||..|:.:...  .|||||.||:.||:.|..||:||:|:||.:..|.|:::|||.||..
Human   488 GQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQG 552

  Fly   545 DPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGI 606
            .|.:|::||..:|.|:.:||:.|   .:..:.........||..||.|..||||:||:||.|:..
Human   553 GPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 617

  Fly   607 IHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIW 671
            |||||||||:|:|:|:..|:||||.||||.....|::.:.|:||::|||.|:|:|.:::.:||:|
Human   618 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 682

  Fly   672 SFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAE 736
            |||:|:|||.|||.:|||||...::.:.:::|:|::||.:|..:||.||..||...|.:||.|.:
Human   683 SFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 747

  Fly   737 IIQMLDKLL---HTEMDYIEL 754
            :::.||::|   .|:.:|::|
Human   748 LVEDLDRVLTVTSTDQEYLDL 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	19/100 (19%)
		STYKc	470..741	CDD:214568	123/275 (45%)
		PTKc	474..742	CDD:270623	122/272 (45%)
FGFR3	XP_006713931.1	IGc2	53..110	CDD:197706	15/81 (19%)
		IG	54..125	CDD:214652	17/97 (18%)
		Ig2_FGFR	161..245	CDD:143265	19/90 (21%)
		IG_like	171..245	CDD:214653	16/80 (20%)
		IG_like	260..355	CDD:214653	20/113 (18%)
		Ig3_FGFR	268..356	CDD:143175	17/106 (16%)
		PKc_like	463..797	CDD:304357	134/306 (44%)
		Pkinase_Tyr	476..752	CDD:285015	123/275 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770