DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and FGFR1

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_001167538.1 Gene:FGFR1 / 2260 HGNCID:3688 Length:853 Species:Homo sapiens


Alignment Length:896 Identity:248/896 - (27%)
Similarity:383/896 - (42%) Gaps:261/896 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 HCRKQLTSWRRRSLLLTIIVVTATVV------SLISQ--------EAEAHNQNAPPILYVRER-- 62
            :||..:.||  :.||...::||||:.      :|..|        |.|:...:...:|.:|.|  
Human    29 NCRTGMWSW--KCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLR 91

  Fly    63 ------NW-----RISETEKVGQIIDRVRAED---------------PDGDD-LIFGIEPRFSLP 100
                  ||     :::|:.:.....:.|..:|               |.|.| ..|.:....:||
Human    92 DDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP 156

  Fly   101 GGE-----NDASPPEK---------------IPFQIDRETGVV--------------TLNESLAG 131
            ..|     :|:|..||               .|.:::::...|              |.|.:|..
Human   157 SSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRW 221

  Fly   132 -RAGQNF----------LIYIT---VTD-------GSYTAKNEVFINILGERENSSGYRPQTSIS 175
             :.|:.|          :.|.|   :.|       |:||.       |:   ||..|....|...
Human   222 LKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC-------IV---ENEYGSINHTYQL 276

  Fly   176 NVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNN-------YPPPPP 233
            :||          ::.|....::.|||.::               ....|:|       |..|.|
Human   277 DVV----------ERSPHRPILQAGLPANK---------------TVALGSNVEFMCKVYSDPQP 316

  Fly   234 NIP-----GVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAETTT 293
            :|.     .|.|.:.|.:..|..::..|..|   :||.|....|      :...|......|.|.
Human   317 HIQWLKHIEVNGSKIGPDNLPYVQILKTAGV---NTTDKEMEVL------HLRNVSFEDAGEYTC 372

  Fly   294 PSG-----GHHNNSSSPITIFSLKSG-----TIP-----IVVTVGGFFVAIAV--LLAYLCRRRL 341
            .:|     .||   |:.:|:......     |.|     |:...|.|.::..|  ::.|      
Human   373 LAGNSIGLSHH---SAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVY------ 428

  Fly   342 CAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIAT 406
                    |.|              |.|...|..:.|.:.:       ..:.:|..|.    :..
Human   429 --------KMK--------------SGTKKSDFHSQMAVHK-------LAKSIPLRRQ----VTV 460

  Fly   407 SQLSTGVTNGGV--------SSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRW 463
            |..|:...|.||        ||.|.|               :..|......||:        .||
Human   461 SADSSASMNSGVLLVRPSRLSSSGTP---------------MLAGVSEYELPED--------PRW 502

  Fly   464 EFPRYRLKFFNILGEGAFGQVWRCEATNINGNE--GITTVAVKTLKESATEVDRKDLLSELEVMK 526
            |.||.||.....||||.||||...||..::.::  .:|.||||.||..|||.|..||:||:|:||
Human   503 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMK 567

  Fly   527 SLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLT 588
            .:..|.|:::|||.||...|.:||:||.::|.|:.||::.|   .|..|..:|.....|:|.||.
Human   568 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 632

  Fly   589 SFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRW 653
            |..||||:||:||.|:..|||||||||:|:|:|:..|:||||.|||:.....|::.:.|:||::|
Human   633 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW 697

  Fly   654 MATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYN 718
            ||.|:|:|.|::.:||:||||:|:|||.|||.:||||:...::.:.:::|:|::||.:|..|||.
Human   698 MAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYM 762

  Fly   719 IMYYCWSHDPQERPLFAEIIQMLDKL--LHTEMDYIELE--------RFPD 759
            :|..||...|.:||.|.::::.||::  |.:..:|::|.        .|||
Human   763 MMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPD 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 28/169 (17%)
PTKc 474..742 CDD:270623 125/272 (46%)
FGFR1NP_001167538.1 IgI_1_FGFR 58..151 CDD:409362 16/92 (17%)
Ig strand A 58..61 CDD:409362 0/2 (0%)
Ig strand A' 73..79 CDD:409362 1/5 (20%)
Ig strand B 82..92 CDD:409362 3/9 (33%)
Ig strand C 96..101 CDD:409362 2/4 (50%)
Ig strand C' 104..106 CDD:409362 0/1 (0%)
Ig strand D 111..115 CDD:409362 0/3 (0%)
Ig strand E 118..123 CDD:409362 1/4 (25%)
Ig strand F 129..138 CDD:409362 0/8 (0%)
Ig strand G 141..151 CDD:409362 3/9 (33%)
IgI_2_FGFR 184..278 CDD:409443 18/103 (17%)
Ig strand A 184..187 CDD:409443 0/2 (0%)
Ig strand A' 195..200 CDD:409443 0/4 (0%)
Ig strand B 204..212 CDD:409443 0/7 (0%)
Ig strand C 218..223 CDD:409443 1/4 (25%)
Ig strand C' 226..228 CDD:409443 0/1 (0%)
Ig strand D 237..240 CDD:409443 0/2 (0%)
Ig strand E 244..249 CDD:409443 0/4 (0%)
Ig strand F 258..265 CDD:409443 3/16 (19%)
Ig strand G 268..278 CDD:409443 2/9 (22%)
Ig 286..390 CDD:472250 27/130 (21%)
Ig strand B 304..308 CDD:409353 0/3 (0%)
Ig strand C 317..321 CDD:409353 1/3 (33%)
Ig strand E 355..359 CDD:409353 1/9 (11%)
Ig strand F 369..374 CDD:409353 2/4 (50%)
Ig strand G 382..385 CDD:409353 2/5 (40%)
PTKc_FGFR1 495..796 CDD:270678 137/308 (44%)

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