DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and FGFR1

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	886	Identity:	244/886 - (27%)
Similarity:	377/886 - (42%)	Gaps:	261/886 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HCRKQLTSWRRRSLLLTIIVVTATVV------SLISQ--------EAEAHNQNAPPILYVRER-- 62
            :||..:.||  :.||...::||||:.      :|..|        |.|:...:...:|.:|.|
Human    29 NCRTGMWSW--KCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLR 91

  Fly    63 ------NW-----RISETEKVGQIIDRVRAED---------------PDGDD-LIFGIEPRFSLP 100
                  ||     :::|:.:.....:.|..:|               |.|.| ..|.:....:||
Human    92 DDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP 156

  Fly   101 GGE-----NDASPPEK-----------------IPFQIDRETGVV--------------TLNESL 129
            ..|     :|:|..||                 .|.:::::...|              |.|.:|
Human   157 SSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTL 221

  Fly   130 AG-RAGQNF----------LIYIT---VTD-------GSYTAKNEVFINILGERENSSGYRPQTS 173
            .. :.|:.|          :.|.|   :.|       |:||.       |:   ||..|....|.
Human   222 RWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC-------IV---ENEYGSINHTY 276

  Fly   174 ISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNN-------YPPP 231
            ..:||          ::.|....::.|||.::               ....|:|       |..|
Human   277 QLDVV----------ERSPHRPILQAGLPANK---------------TVALGSNVEFMCKVYSDP 316

  Fly   232 PPNIP-----GVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAET 291
            .|:|.     .|.|.:.|.:..|..::..|..|   :||.|....|      :...|......|.
Human   317 QPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGV---NTTDKEMEVL------HLRNVSFEDAGEY 372

  Fly   292 TTPSG-----GHHNNSSSPITIFSLKSG-----TIP-----IVVTVGGFFVAIAV--LLAYLCRR 339
            |..:|     .||   |:.:|:......     |.|     |:...|.|.::..|  ::.|
Human   373 TCLAGNSIGLSHH---SAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVY---- 430

  Fly   340 RLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGI 404
                      |.|              |.|...|..:.|.:.:       ..:.:|..|.    :
Human   431 ----------KMK--------------SGTKKSDFHSQMAVHK-------LAKSIPLRRQ----V 460

  Fly   405 ATSQLSTGVTNGGV--------SSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCD 461
            ..|..|:...|.||        ||.|.|               :..|......||:        .
Human   461 TVSADSSASMNSGVLLVRPSRLSSSGTP---------------MLAGVSEYELPED--------P 502

  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNE--GITTVAVKTLKESATEVDRKDLLSELEV 524
            |||.||.||.....||||.||||...||..::.::  .:|.||||.||..|||.|..||:||:|:
Human   503 RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEM 567

  Fly   525 MKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCD 586
            ||.:..|.|:::|||.||...|.:||:||.::|.|:.||::.|   .|..|..:|.....|:|.|
Human   568 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 632

  Fly   587 LTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPI 651
            |.|..||||:||:||.|:..|||||||||:|:|:|:..|:||||.|||:.....|::.:.|:||:
Human   633 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV 697

  Fly   652 RWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRREL 716
            :|||.|:|:|.|::.:||:||||:|:|||.|||.:||||:...::.:.:::|:|::||.:|..||
Human   698 KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNEL 762

  Fly   717 YNIMYYCWSHDPQERPLFAEIIQMLDKL--------LHTEM 749
            |.:|..||...|.:||.|.::::.||::        ||.::
Human   763 YMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQVLHPDL 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	28/171 (16%)
		STYKc	470..741	CDD:214568	126/275 (46%)
		PTKc	474..742	CDD:270623	125/272 (46%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	13/77 (17%)
		IG_like	77..151	CDD:214653	12/73 (16%)
		I-set	193..280	CDD:254352	17/96 (18%)
		Ig2_FGFR	196..280	CDD:143265	17/93 (18%)
		IG_like	295..391	CDD:214653	24/122 (20%)
		Ig3_FGFR	303..392	CDD:143175	24/100 (24%)
		PTKc_FGFR1	497..797	CDD:270678	136/307 (44%)
		Pkinase_Tyr	511..787	CDD:285015	126/275 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770