DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Tek

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus

Alignment Length:	842	Identity:	222/842 - (26%)
Similarity:	338/842 - (40%)	Gaps:	209/842 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDL---IFGIEPRFSLP-GGENDAS 107
            |.::....||  .:...|.:..:|::..:       .|||..|   .|....|||:. ...|...
Mouse   360 EVNSGKFNPI--CKASGWPLPTSEEMTLV-------KPDGTVLQPNDFNYTDRFSVAIFTVNRVL 415

  Fly   108 PPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYTAKNEV-------FINILGERENS 165
            ||       |....|.::| ::||...:.|.|.:.|......|.|.:       .|||..|....
Mouse   416 PP-------DSGVWVCSVN-TVAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFG 472

  Fly   166 SG--------YRP------QTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQN 216
            .|        |:|      ...::|.:..::...||.|....||..|.|     .||...|.|..
Mouse   473 DGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEPRTDYELCVQLARPG-----EGGEGHPGPVR 532

  Fly   217 NIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLT----PITA 277
            . |.....|  .|||       ||                     .|..|||:|.|.    ||..
Mouse   533 R-FTTASIG--LPPP-------RG---------------------LSLLPKSQTALNLTWQPIFT 566

  Fly   278 NNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLC 342
            |:.......:...:...:....|                   :.|.|...  :|||:.|..|...
Mouse   567 NSEDEFYVEVERRSLQTTSDQQN-------------------IKVPGNLT--SVLLSNLVPREQY 610

  Fly   343 AISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRN--------SMVMQQW-----QGPVAFANRYV 394
            .: |....||.:.|.:::.....||..|.....|        |..|..|     ....:...||.
Mouse   611 TV-RARVNTKAQGEWSEELRAWTLSDILPPQPENIKISNITDSTAMVSWTIVDGYSISSIIIRYK 674

  Fly   395 PWERDQQMGIATSQLSTGVT---------------------NGGVSSPG-------VP-SPGTGE 430
            ...:::...|.....:..||                     |.|.|:|.       :| ||.:
Mouse   675 VQGKNEDQHIDVKIKNATVTQYQLKGLEPETTYHVDIFAENNIGSSNPAFSHELRTLPHSPAS-- 737

  Fly   431 PGSNLGPG-----CLTGGAG----------------------------------------SSGAP 450
              ::||.|     .:.|.||                                        :||..
Mouse   738 --ADLGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTL 800

  Fly   451 ENAFAGEANCDRWEFPRY---RLKFFNILGEGAFGQVWRCEATNINGNEGI-TTVAVKTLKESAT 511
            ......:.|.|...:|..   .:||.:::|||.||||.:....    .:|: ...|:|.:||.|:
Mouse   801 ALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIK----KDGLRMDAAIKRMKEYAS 861

  Fly   512 EVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYG 573
            :.|.:|...||||:..|..|.|:::|||.|..:...::.:||...|.|..:||.||   .:..:.
Mouse   862 KDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA 926

  Fly   574 NTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITS 638
            ..:..::.|:|..|..|...||:|||||:.:..|||||||||||:.:::..|:||||.:|.   .
Mouse   927 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRG---Q 988

  Fly   639 KIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDG 703
            ::|.:|:.|:||:||||.|||..::::..||:||:|:|:||||:||.|||.|::.|::..|:..|
Mouse   989 EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 1053

  Fly   704 YRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNI 765
            ||||||.:|..|:|::|..||...|.|||.||:|:..|:::|.....|:....:....|..|
Mouse  1054 YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGI 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	26/109 (24%)
		STYKc	470..741	CDD:214568	114/274 (42%)
		PTKc	474..742	CDD:270623	112/271 (41%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		EGF_2	311..340	CDD:285248
		fn3	445..516	CDD:278470	13/70 (19%)
		fn3	542..625	CDD:278470	26/132 (20%)
		FN3	638..730	CDD:238020	13/91 (14%)
		PTKc_Tie2	815..1117	CDD:133219	120/308 (39%)
		STYKc	823..1091	CDD:214568	114/274 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910