Protein Alignment Cad96Ca and Ros1

DIOPT Version :10

• Sequence 1: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Sequence 2: XP_011241449.1
• Gene: Ros1 / 19886
• MGIID: 97999
• Length: 2341
• Species: Mus musculus
• Alignment Length: 816
• Identity: 224/816 - (27%)
• Similarity: 328/816 - (40%)
• Gaps: 226/816 - (27%)

  Fly    34 VTATVVSLISQE---AEAHNQNAPPILYVRERNWRISETEKVG-QIIDRVRAEDPDGDDLIFGIE 94
            :.|||:|..|..   .|:|..|.|              .|.|. |::....|..|:
Mouse  1558 INATVLSDTSLHVFWTESHKPNGP--------------KESVRYQLVMSYLAPIPE--------- 1599

  Fly    95 PRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGS---YTAKNEVFI 156
              ..|..||   .|..|:...|.:.:|            ||.:::.:......   .|..:.|.:
Mouse  1600 --TPLRQGE---FPSAKLSLLITKLSG------------GQLYVMKVLACHPEEMWCTESHPVSV 1647

  Fly   157 NILGERENSSGYRPQ-TSI-------SNVVHNISQF-----LPRFDQLPGVQ-SIRNGLPNSRPG 207
            |:....|..|...|: ||:       |||  |::.|     ..::::...|: |...|
Mouse  1648 NMFDTPEKPSALVPENTSLQLDWKARSNV--NLTGFWFELQKWKYNEFYHVKASCSQG------- 1703

  Fly   208 GWYPPVPQNNIFGPPPF-------------GNNYPPPP---------PNIPGVRGEQSGEEEQPD 250
                ||...||....|:             |.|....|         |:.||:.....|.:....
Mouse  1704 ----PVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQ 1764

  Fly   251 EEVTPTTPVRISSTTPKSRTKLTPITANNSTRVE-------SAI--------------PAETTTP 294
            .|.......|:...|.:.|..::..:.|.|:|.:       |:|              .|.....
Mouse  1765 WEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANE 1829

  Fly   295 SG-GHHNNSSSPITIFSLKSG-----TIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTK- 352
            .| |.::..|..||:  ::.|     |..|:..:.|.|:...|.|.::..       |:||..|
Mouse  1830 IGLGEYSEISEDITL--VEDGVWITETSFILTIIVGIFLVATVPLTFVWH-------RSLKSHKA 1885

  Fly   353 EKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGG 417
            .||.|          |.|.|:.:                     |..:..|:|.   ..|:.|..
Mouse  1886 SKEGL----------SVLNDNDK---------------------ELAELRGLAA---GVGLANAC 1916

  Fly   418 VSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFG 482
            .:...||   |.|...|| |.                          |||.:|....:||.||||
Mouse  1917 YAVHTVP---TQEEIENL-PA--------------------------FPREKLSLRLLLGSGAFG 1951

  Fly   483 QVWRCEATNING-NEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDP 546
            :|:...|.:|.| ..|...|||||||:.:|:.::.:.|.|..:|.... |.|::..||.|...:|
Mouse  1952 EVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN-HPNILKQLGVCLLGEP 2015

  Fly   547 TFVILEYVNRGKLQTYLRSSRAERHYGNT-HGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRD 610
            .::|||.:..|.|.:|||.:|     |.| ||.|  ||..||......::||..||.....||||
Mouse  2016 QYIILELMEGGDLLSYLRKAR-----GTTFHGPS--LTLLDLVELCVDISKGCVYLEQMHFIHRD 2073

  Fly   611 LAARNILI-----TDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDI 670
            |||||.|:     |.....|:.|||.||::..:..|.::.||.||:||||.|:|.|.||:.:||:
Mouse  2074 LAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDV 2138

  Fly   671 WSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFA 735
            ||||||:|||:|||..|||..|..||:..|:.|.|||.|.:|..:|:|:|..||:.:|.:||.|
Mouse  2139 WSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTF- 2202

  Fly   736 EIIQMLDKLLHTEMDYIELERFPDHNYYNIVSLSGE 771
                      |...:.::|.|   :.:.|.||..||
Mouse  2203 ----------HNIQNQLQLFR---NVFLNNVSHCGE 2225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	17/102 (17%)
		PTKc	474..742	CDD:270623	117/274 (43%)
Ros1	XP_011241449.1	FN3	<100..>296	CDD:442628
		FN3	568..664	CDD:238020
		FN3	1037..1143	CDD:238020
		FN3	<1502..>1753	CDD:442628	50/247 (20%)
		FN3	1651..1742	CDD:238020	21/103 (20%)
		FN3	1747..1840	CDD:238020	16/92 (17%)
		PTKc_c-ros	1949..2210	CDD:270640	115/279 (41%)