DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Ret

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_033076.2	Gene:	Ret / 19713	MGIID:	97902	Length:	1115	Species:	Mus musculus

Alignment Length:	304	Identity:	131/304 - (43%)
Similarity:	197/304 - (64%)	Gaps:	12/304 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMK 526
            :|||||..|.....||||.||:|.:..|..:.|..|.||||||.|||:|::.:.:|||||..::|
Mouse   717 KWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLK 781

  Fly   527 SLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR----------AERHYGN-THGKSN 580
            .:. |.:|:.|.|.|:...|..:|:||...|.|:.:||.||          ..|:..: .|....
Mouse   782 QVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSLDHPDER 845

  Fly   581 VLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKS 645
            |||..||.||.:|:::||.||....::||||||||||:.:....|::|||.:|||.....|.:||
Mouse   846 VLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKS 910

  Fly   646 EGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPE 710
            :|::|::|||.|||:|:|::.:||:||||:|:|||||||..|||||....:...::.|:|:|:|:
Mouse   911 KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD 975

  Fly   711 HCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIEL 754
            :|..|:|.:|..||..:|.:||:||:|.:.|:|::....||::|
Mouse   976 NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDL 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	121/281 (43%)
		PTKc	474..742	CDD:270623	120/278 (43%)
Ret	NP_033076.2	Cadherin	173..262	CDD:278457
		PTKc_RET	724..1013	CDD:173631	123/289 (43%)
		Pkinase_Tyr	725..1006	CDD:285015	121/281 (43%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810