DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and egl-15

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	343	Identity:	136/343 - (39%)
Similarity:	199/343 - (58%)	Gaps:	25/343 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 ENAFAGEANCDR---WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATE 512
            ||....|...|.   ||..|.:|...::|||||||:||:........||  ..||||.||.||.|
Worm   618 ENTVLSEYEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKETENNE--IAVAVKKLKMSAHE 680

  Fly   513 VDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYG---- 573
            .:..||:||:|..|.:..|.||:.|:||||...|.:|::|....|.|:.:||:.|.:....
Worm   681 KELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSS 745

  Fly   574 ----------NTHGKSNV-----LTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHT 623
                      ....|.::     ||...|..|.:|||:||::|.|:.||||||||||:|:.|.|.
Worm   746 QELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHV 810

  Fly   624 CKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPY 688
            .|::|||.:|||..:..|.::..|:|||:|||.|:|..|:::|:||:||:|:|:|||:|||.|||
Worm   811 LKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPY 875

  Fly   689 PGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIE 753
            |.|:..::...:::|||:|.|..|.:|:|::|..||....:|||.|..|:..||.:|....:.||
Worm   876 PTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTNETIE 940

  Fly   754 -LERFPDHNYYNIVSLSG 770
             .:.|.|..:....:.||
Worm   941 GSQEFNDQFFSERSTASG 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	120/289 (42%)
		PTKc	474..742	CDD:270623	119/286 (42%)
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653
		Ig	47..126	CDD:299845
		Ig	302..382	CDD:299845
		IG_like	306..384	CDD:214653
		IG_like	401..502	CDD:214653
		Ig3_FGFR	407..503	CDD:143175
		PKc_like	627..933	CDD:304357	126/307 (41%)
		Pkinase_Tyr	640..928	CDD:285015	120/289 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010