DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and kin-9

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001257058.1	Gene:	kin-9 / 181098	WormBaseID:	WBGene00002195	Length:	585	Species:	Caenorhabditis elegans

Alignment Length:	761	Identity:	189/761 - (24%)
Similarity:	292/761 - (38%)	Gaps:	225/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LTIIVVTATVVSLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDLIFGI 93
            ||.:..:|.:||.::....|.:.:        ..:|...::.|..     .....|....:..|.
Worm     6 LTYLASSAALVSTLAFPTPAVDDS--------HEDWSAYKSRKYS-----TWTPSPQPSTMNAGT 57

  Fly    94 EPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYI-TVTDGSYTAKNEV--F 155
            :..|.....|||.......|..|.                      |: |:|:.|..|.|.|  .
Worm    58 QTDFRTARNENDNQNHNLSPSDIR----------------------YLETITNLSQQALNNVKST 100

  Fly   156 INILGERENSSGYRPQTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRP---GGW------YP 211
            |:.:.|.|     .|.||...     ||:     |.|.         |::|   |.|      ||
Worm   101 IDTINEVE-----PPITSPPR-----SQY-----QAPW---------NNQPYQQGSWASQYAPYP 141

  Fly   212 PV-PQNNIFGP--PPFGNN-----YPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKS 268
            .: |::.:|.|  ||...:     .|||||:.|               ...||||:.....
Worm   142 TLPPEHLVFHPHKPPHHQDDSLEKNPPPPPHKP---------------RHLPTTPLYYDPY---- 187

  Fly   269 RTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGT-IPIVVTVGGFFVAIAVL 332
                                      .||..::|...:...:|..|. ||:.:...|    :|:.
Worm   188 --------------------------YGGDKHSSEGGVNAVALGLGIGIPLGIIAFG----LALF 222

  Fly   333 LAYLCRRRLCAISRTLKKTKEKEELAKKSN--QSQLSS---TLTDDSRNSMVMQQWQGPVAFANR 392
            :.:.||:|     |...|.:......||.|  ::||.|   ::.|
Worm   223 IFFWCRKR-----RRQNKNQFPLPFPKKVNDYETQLDSPAYSIHD-------------------- 262

  Fly   393 YVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGE 457
              ||..|:      :.|....:                  ..||          |||..|.|.|:
Worm   263 --PWLLDR------NNLEINYS------------------KKLG----------SGAFCNVFKGK 291

  Fly   458 ANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSEL 522
            .|                 ||....|:...:.|.:..:   ..||||.|...|.:..|.|.:.|:
Worm   292 IN-----------------GEAPVSQIHPGQRTQLLRD---CPVAVKMLPSFADDAARSDFMQEI 336

  Fly   523 EVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDL 587
            ..||||..|.::|.:||...|:...::::|:...|.|...:|:.|.|...|.|..... |...||
Worm   337 NFMKSLAYHPHLVSMLGFVADRKSPYLLVEFCEHGDLLHMIRNRRQEIINGPTENPDG-LKIKDL 400

  Fly   588 TSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIR 652
            ..|.:|::.|::||.:.|.||||:||||:|:...:|||:.|||..|  :|..:......|:||::
Worm   401 LMFSWQISNGLEYLNNIGCIHRDIAARNVLVDSANTCKIGDFGLCR--LTDSLLYTARGGRLPLK 463

  Fly   653 WMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELY 717
            |||.|||....:|.|||:||:|:|:||:.:||..||..:...::::..|.|.||.|||.|..|:|
Worm   464 WMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVPYGEVQTTELLQTHRSGKRLLKPEWCPEEIY 528

  Fly   718 NIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMD---YIELERFPDH 760
            ::|..||...|.:||.|.:...:|.::|....:   |:    .|.|
Worm   529 DVMRLCWQELPDDRPAFQQTCAVLAQMLENATENYGYL----IPKH 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	18/101 (18%)
		STYKc	470..741	CDD:214568	96/270 (36%)
		PTKc	474..742	CDD:270623	96/267 (36%)
kin-9	NP_001257058.1	SKG6	194..230	CDD:370068	9/39 (23%)
kin-9	NP_001257058.1	PTKc	277..557	CDD:270623	106/312 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010