DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and T22B11.4

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001334224.1	Gene:	T22B11.4 / 177234	WormBaseID:	WBGene00020678	Length:	892	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	148/727 - (20%)
Similarity:	251/727 - (34%)	Gaps:	174/727 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DGDDLIFGIEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYT 149
            ||.:::.|.....:|||...||.....: .|:|::.|.|: .|:    .|.||.        ...
Worm   289 DGSEIVDGPPQEDALPGPVKDAEETATV-VQVDKDEGDVS-EET----GGTNFF--------EEE 339

  Fly   150 AKNEVFINILGERENSSGYRPQTSISNVVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVP 214
            .|.|.     ||.:.......:..:..|  |:....|  .:|...:..:.
Worm   340 EKKEE-----GETKKEESSEEEDGVLKV--NLEDIEP--TKLKSQEDAKK--------------- 380

  Fly   215 QNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANN 279
                                      ::..|||:.|||...||.|.......|..........:.
Worm   381 --------------------------KEGDEEEEKDEEEAETTTVVKEDEEKKEGDNEGDKEEDK 419

  Fly   280 STRVES-------AIPAETTTPSGGHHNNSSSPITIFSLKSGTIPIV------------------ 319
            ..:.||       ....||||.|.......|:.......:|.|:.:|
Worm   420 EDKKESEEEEEKDGDDEETTTTSEDDEEKDSNSDEDEDEESTTVELVEGETPDPSEQNFLQRIYY 484

  Fly   320 ----VTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVM 380
                :.|....:|..::.|..|...||.|.:. |..|.||  :|.||..:.:|...........:
Worm   485 SPDYLRVRNITIATLIIFAVFCSLGLCCIYKN-KCCKSKE--SKTSNGYRYTSANPPPPTELKTV 546

  Fly   381 QQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAG 445
            .:....||        ..|:...:|..:......|                         ...:|
Worm   547 SRVPSGVA--------PEDEHHLLAADEAIENFKN-------------------------VVKSG 578

  Fly   446 SSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESA 510
            ::.:|:|...|..                 :|.|.||.:.|...::.||:  :..|.|..||..|
Worm   579 TTFSPKNVELGIT-----------------VGMGKFGPIHRAMFSSFNGS--VHDVNVYLLKNIA 624

  Fly   511 TEVDRKDLLSELEVMKS---LEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHY 572
            ...| ::|:....::||   ...|.|||.|.|.........::.|.:::..|:..||.||..|..
Worm   625 RLSD-EELVKLTSLLKSNIAAGAHQNVVSLCGVSPSGSDVMLMWEPLHQSVLRGVLRESRCARFG 688

  Fly   573 GNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFAR---- 633
            ......::.|:|..|.:.......|:::|..:.:....|:..|:|:.:....|:..||.|.
Worm   689 TEPFNMASFLSSERLAAIAIGCCNGVEHLLKKNVFPPHLSTSNVLLAERGIVKIGGFGLAEHHAL 753

  Fly   634 DVITSKIYERKSEGKLPIRWMATESLYDN---IFSVKSDIWSFGILMWEIVTLGSTPYPGISAAD 695
            |:.|       ......:|||..|....:   |::.::.||..|:.:|||.:||.||:..:..|.
Worm   754 DMTT-------ESAPTKLRWMPPEYFKRDQKMIYNEQTMIWPLGVTLWEIFSLGGTPFGSLRQAQ 811

  Fly   696 V-MRKVRDG-YRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKL---LHTEMDYIELE 755
            . :..:||| .:|:...:|...:..::..|.||.|:.|.....||:.|:.:   ..|:::....|
Worm   812 TFIDAMRDGSAQLDPISYCGEAVTQLLATCTSHVPEARGDIRTIIKRLECISADAKTQINLCYRE 876

  Fly   756 RFPDHNYYNIVS 767
            .||   |..||:
Worm   877 DFP---YLPIVT 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	20/78 (26%)
		STYKc	470..741	CDD:214568	71/282 (25%)
		PTKc	474..742	CDD:270623	71/279 (25%)
T22B11.4	NP_001334224.1	PKc_like	592..860	CDD:389743	71/277 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100