DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Kit

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus

Alignment Length:	369	Identity:	131/369 - (35%)
Similarity:	191/369 - (51%)	Gaps:	72/369 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 RWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMK 526
            :|||||.||.|...||.||||:|....|..:..::...|||||.||.||...:|:.|:|||:|:.
Mouse   584 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLS 648

  Fly   527 SLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKS------NVL--- 582
            .|..|:|:|:|||.||...||.||.||...|.|..:||..|....:.....::      |:|
Mouse   649 YLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHST 713

  Fly   583 -TSC----------------------------------------------------DLTSFMYQV 594
             .||                                                    ||.||.|||
Mouse   714 EPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQV 778

  Fly   595 AKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESL 659
            ||||.:|.|:..|||||||||||:|.....|:.|||.|||:.....|..|...:||::|||.||:
Mouse   779 AKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESI 843

  Fly   660 YDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA-ADVMRKVRDGYRLEKPEHCRRELYNIMYYC 723
            :..:::.:||:||:||.:||:.:|||:||||:.. :...:.:::|:|:..|||...|:|::|..|
Mouse   844 FSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTC 908

  Fly   724 WSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIVS 767
            |..||.:||.|.:::|:::|         ::.....|.|.|:.:
Mouse   909 WDADPLKRPTFKQVVQLIEK---------QISDSTKHIYSNLAN 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	121/333 (36%)
		PTKc	474..742	CDD:270623	119/330 (36%)
Kit	NP_001116205.1	ig	217..308	CDD:278476
		IG_like	221..310	CDD:214653
		Ig4_SCFR	314..414	CDD:143268
		IG_like	325..412	CDD:214653
		Ig	427..501	CDD:299845
		PTKc_Kit	556..930	CDD:270682	128/354 (36%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573
		Pkinase_Tyr	592..926	CDD:285015	121/333 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810