DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and Flt4

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_032055.1	Gene:	Flt4 / 14257	MGIID:	95561	Length:	1363	Species:	Mus musculus

Alignment Length:	963	Identity:	240/963 - (24%)
Similarity:	369/963 - (38%)	Gaps:	339/963 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVR------------AEDPDGDDLIFG 92
            |:::....:.|...|   ||.|.|..|....:..::|...:            .|...||:|:
Mouse   293 SILTIHNVSQNDLGP---YVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDELV-- 352

  Fly    93 IEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTD---GSYT----- 149
                 .|| .:..|.||.:..:..||        :::.||...:.|:...||:   |.||
Mouse   353 -----KLP-VKLAAYPPPEFQWYKDR--------KAVTGRHNPHALVLKEVTEASAGVYTLALWN 403

  Fly   150 -----AKN---EVFINI---LGERENSS---------------------------GYRPQTSISN 176
                 .:|   |:.:|:   :.|:|.||                           .:||.|....
Mouse   404 SAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKT 468

  Fly   177 VVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPG---- 237
            ..   .:.|.|..|       |:|:|..|  .|.....|:.:           .|..::..
Mouse   469 FA---QRSLRRRQQ-------RDGMPQCR--DWKEVTTQDAV-----------NPIESLDSWTEF 510

  Fly   238 VRGEQS------------------------GEEE------------------QPDEEVTPTTPVR 260
            |.|:..                        |::|                  :|.|:......||
Mouse   511 VEGKNKTVSKLVIQDANVSAMYKCVVVNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVR 575

  Fly   261 IS------------------STTPKSRTK------------LTPITANNSTRVESAIPAETTTPS 295
            :|                  ||...::..            .||:.||    :|.|.|
Mouse   576 LSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEAN----LEEAEP------- 629

  Fly   296 GGHHNNSSSPITIFSLKSGTIPIVVTVG-GFFVAIAVLLAYLCRRRLCAIS--RTLKKTKEKEEL 357
            |..|          :..|..||.|.... |.:|              |.:.  |:..|...|:.|
Mouse   630 GARH----------ATLSLNIPRVAPEDEGDYV--------------CEVQDRRSQDKHCHKKYL 670

  Fly   358 AKKSNQS-QLSSTLTDDSRNSMVMQQWQGPVAFANRYVP---WERDQQM-----GI----ATSQL 409
            :.::.:: :|:..|||...|.....:.:.|||.|  :||   |.:|:::     ||    :..:|
Mouse   671 SVQALEAPRLTQNLTDLLVNVSDSLEMRCPVAGA--HVPSIVWYKDERLLEKESGIDLADSNQRL 733

  Fly   410 S-------------------TGVTNGGVSSPGVPSPGTGEPGSN-----LGPGCL---------- 440
            |                   .|..|   ||..|...|:.:.||.     :|.|.:
Mouse   734 SIQRVREEDAGRYLCSVCNAKGCVN---SSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLL 795

  Fly   441 --------------TG------GAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVW 485
                          ||      ..|.....|.......:..:|||||.||....:||.||||:|.
Mouse   796 IFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVV 860

  Fly   486 RCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKD-PTFV 549
            ...|..||......|||||.|||.||..:.:.|:|||:::..:..|:|||:|||.||..: |..|
Mouse   861 EASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMV 925

  Fly   550 ILEYVNRGKLQTYLRSSR------AE--------------------RHYGNTH---------GKS 579
            |:|:...|.|..:||..|      ||                    |..|::.         ||.
Mouse   926 IVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKG 990

  Fly   580 NV----------------LTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVAD 628
            :.                ||..||..:.:|||:||::|.||..|||||||||||:::....|:.|
Mouse   991 SARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICD 1055

  Fly   629 FGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA 693
            ||.|||:.....|.||...:||::|||.||::|.:::.:||:||||:|:|||.:||::||||:..
Mouse  1056 FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQI 1120

  Fly   694 -ADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLL 745
             .:..::::||.|:..||.....:.:||..|||.||:.||.|::::::|..||
Mouse  1121 NEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLL 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	25/129 (19%)
		STYKc	470..741	CDD:214568	121/323 (37%)
		PTKc	474..742	CDD:270623	120/320 (38%)
Flt4	NP_032055.1	IG_like	238..327	CDD:214653	8/36 (22%)
		Ig1_VEGFR	245..329	CDD:143270	9/38 (24%)
		IG_like	341..415	CDD:214653	20/89 (22%)
		Ig	352..418	CDD:299845	17/81 (21%)
		Ig	569..662	CDD:299845	22/127 (17%)
		IG	570..663	CDD:214652	22/127 (17%)
		I-set	678..765	CDD:254352	22/91 (24%)
		IGc2	693..755	CDD:197706	12/63 (19%)
		PKc_like	837..1175	CDD:304357	130/337 (39%)
		Pkinase_Tyr	845..1169	CDD:285015	121/323 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810