DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and Flt4

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_032055.1 Gene:Flt4 / 14257 MGIID:95561 Length:1363 Species:Mus musculus


Alignment Length:963 Identity:240/963 - (24%)
Similarity:369/963 - (38%) Gaps:339/963 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 SLISQEAEAHNQNAPPILYVRERNWRISETEKVGQIIDRVR------------AEDPDGDDLIFG 92
            |:::....:.|...|   ||.|.|..|....:..::|...:            .|...||:|:  
Mouse   293 SILTIHNVSQNDLGP---YVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDELV-- 352

  Fly    93 IEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTD---GSYT----- 149
                 .|| .:..|.||.:..:..||        :::.||...:.|:...||:   |.||     
Mouse   353 -----KLP-VKLAAYPPPEFQWYKDR--------KAVTGRHNPHALVLKEVTEASAGVYTLALWN 403

  Fly   150 -----AKN---EVFINI---LGERENSS---------------------------GYRPQTSISN 176
                 .:|   |:.:|:   :.|:|.||                           .:||.|....
Mouse   404 SAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKT 468

  Fly   177 VVHNISQFLPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPFGNNYPPPPPNIPG---- 237
            ..   .:.|.|..|       |:|:|..|  .|.....|:.:           .|..::..    
Mouse   469 FA---QRSLRRRQQ-------RDGMPQCR--DWKEVTTQDAV-----------NPIESLDSWTEF 510

  Fly   238 VRGEQS------------------------GEEE------------------QPDEEVTPTTPVR 260
            |.|:..                        |::|                  :|.|:......||
Mouse   511 VEGKNKTVSKLVIQDANVSAMYKCVVVNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVR 575

  Fly   261 IS------------------STTPKSRTK------------LTPITANNSTRVESAIPAETTTPS 295
            :|                  ||...::..            .||:.||    :|.|.|       
Mouse   576 LSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEAN----LEEAEP------- 629

  Fly   296 GGHHNNSSSPITIFSLKSGTIPIVVTVG-GFFVAIAVLLAYLCRRRLCAIS--RTLKKTKEKEEL 357
            |..|          :..|..||.|.... |.:|              |.:.  |:..|...|:.|
Mouse   630 GARH----------ATLSLNIPRVAPEDEGDYV--------------CEVQDRRSQDKHCHKKYL 670

  Fly   358 AKKSNQS-QLSSTLTDDSRNSMVMQQWQGPVAFANRYVP---WERDQQM-----GI----ATSQL 409
            :.::.:: :|:..|||...|.....:.:.|||.|  :||   |.:|:::     ||    :..:|
Mouse   671 SVQALEAPRLTQNLTDLLVNVSDSLEMRCPVAGA--HVPSIVWYKDERLLEKESGIDLADSNQRL 733

  Fly   410 S-------------------TGVTNGGVSSPGVPSPGTGEPGSN-----LGPGCL---------- 440
            |                   .|..|   ||..|...|:.:.||.     :|.|.:          
Mouse   734 SIQRVREEDAGRYLCSVCNAKGCVN---SSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLL 795

  Fly   441 --------------TG------GAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVW 485
                          ||      ..|.....|.......:..:|||||.||....:||.||||:|.
Mouse   796 IFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVV 860

  Fly   486 RCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKD-PTFV 549
            ...|..||......|||||.|||.||..:.:.|:|||:::..:..|:|||:|||.||..: |..|
Mouse   861 EASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMV 925

  Fly   550 ILEYVNRGKLQTYLRSSR------AE--------------------RHYGNTH---------GKS 579
            |:|:...|.|..:||..|      ||                    |..|::.         ||.
Mouse   926 IVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKG 990

  Fly   580 NV----------------LTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVAD 628
            :.                ||..||..:.:|||:||::|.||..|||||||||||:::....|:.|
Mouse   991 SARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICD 1055

  Fly   629 FGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISA 693
            ||.|||:.....|.||...:||::|||.||::|.:::.:||:||||:|:|||.:||::||||:..
Mouse  1056 FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQI 1120

  Fly   694 -ADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLL 745
             .:..::::||.|:..||.....:.:||..|||.||:.||.|::::::|..||
Mouse  1121 NEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLL 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 25/129 (19%)
PTKc 474..742 CDD:270623 120/320 (38%)
Flt4NP_032055.1 IgI_VEGFR 230..329 CDD:409448 9/38 (24%)
Ig strand A 230..234 CDD:409448
Ig strand A' 240..244 CDD:409448
Ig strand B 246..255 CDD:409448
Ig strand C 262..267 CDD:409448
Ig strand C' 270..272 CDD:409448
Ig strand D 276..284 CDD:409448
Ig strand E 289..297 CDD:409448 1/3 (33%)
Ig strand F 307..313 CDD:409448 4/8 (50%)
Ig strand G 318..324 CDD:409448 0/5 (0%)
Ig 331..418 CDD:472250 21/102 (21%)
Ig strand B 352..356 CDD:409449 2/11 (18%)
Ig strand C 365..369 CDD:409449 0/3 (0%)
Ig strand E 382..386 CDD:409449 1/3 (33%)
Ig strand F 396..401 CDD:409449 2/4 (50%)
Ig strand G 411..414 CDD:409449 1/2 (50%)
IG_like 570..663 CDD:214653 22/127 (17%)
Ig strand B 574..578 CDD:409353 2/3 (67%)
Ig strand C 587..591 CDD:409353 0/3 (0%)
Ig strand E 636..640 CDD:409353 1/3 (33%)
Ig strand F 650..655 CDD:409353 2/18 (11%)
Ig 678..765 CDD:472250 22/91 (24%)
Ig strand B 695..699 CDD:409353 0/3 (0%)
Ig strand C 708..712 CDD:409353 0/3 (0%)
Ig strand E 731..735 CDD:409353 1/3 (33%)
Ig strand F 745..750 CDD:409353 0/4 (0%)
VEGFR-2_TMD 770..804 CDD:375470 4/33 (12%)
Protein Kinases, catalytic domain 837..1175 CDD:473864 130/337 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Blue background indicates that the domain is not in the aligned region.

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