DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Ca and Fgfr3

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001156689.1	Gene:	Fgfr3 / 14184	MGIID:	95524	Length:	802	Species:	Mus musculus

Alignment Length:	801	Identity:	229/801 - (28%)
Similarity:	350/801 - (43%)	Gaps:	183/801 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VYHHHNHESRIIHCRKQLTSWRRRSLLLTIIVVTATVVSLISQEAE--AHNQNAPPILYVRERNW 64
            |.:..:.::.:..|:.:||   ||.|....:.||....|...::.|  |.:..||        .|
Mouse    94 VLNASHEDAGVYSCQHRLT---RRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAP--------YW 147

  Fly    65 RISETEKVGQIIDRVRAEDPDGDDLIFGIEPRFSLPGGENDASPPEKI-------PFQIDRETGV 122
              :..|::.:.:..|.|.:          ..||..|...|   |...|       .|:.:...|.
Mouse   148 --TRPERMDKKLLAVPAAN----------TVRFRCPAAGN---PTPSISWLKNGKEFRGEHRIGG 197

  Fly   123 VTLNESLAGRAGQNFLIYITVTD---GSYTAKNEVFINILGERENSSGYRPQTSISNVVHNISQF 184
            :.|      |..|..|:..:|..   |:||.          ..||..|...||...:|
Mouse   198 IKL------RHQQWSLVMESVVPSDRGNYTC----------VVENKFGSIRQTYTLDV------- 239

  Fly   185 LPRFDQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPP--FGNNYPPPPPNIPGVRG-EQSGEE 246
            |.|....|.:|:   |||.:          |..|.|...  ....|....|:|..::. |.:|.:
Mouse   240 LERSPHRPILQA---GLPAN----------QTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSK 291

  Fly   247 EQPD-------------EEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPAETTTPSGGH 298
            ..||             |.|.....:|:::.:.:...:......|.....|.|.......|....
Mouse   292 VGPDGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAE 356

  Fly   299 ----HNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLA-YLCRRRLCAI----SRTLKKTKE- 353
                ..:.:..:....|..|.:        ||:.|.|:.| .|||.|....    |.|:.|...
Mouse   357 EELMETDEAGSVYAGVLSYGVV--------FFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRF 413

  Fly   354 --KEELAKKSNQSQLSST-LTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGVTN 415
              |.:::.:||.|..|:| |...:|    :...:||| .||
Mouse   414 PLKRQVSLESNSSMNSNTPLVRIAR----LSSGEGPV-LAN------------------------ 449

  Fly   416 GGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGA 480
              ||...:|:    :|                              :||..|.||.....||||.
Mouse   450 --VSELELPA----DP------------------------------KWELSRTRLTLGKPLGEGC 478

  Fly   481 FGQVWRCEATNINGNEGI--TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTD 543
            ||||...||..|:.:...  .|||||.||:.||:.|..||:||:|:||.:..|.|:::|||.||.
Mouse   479 FGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 543

  Fly   544 KDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRG 605
            ..|.:|::||..:|.|:.:||:.|   .:..:.........||..||.|..||||:||:||.|:.
Mouse   544 GGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQK 608

  Fly   606 IIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDI 670
            .|||||||||:|:|:|:..|:||||.||||.....|::.:.|:||::|||.|:|:|.:::.:||:
Mouse   609 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 673

  Fly   671 WSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFA 735
            ||||:|:|||.|||.:|||||...::.:.:::|:|::||..|..:||.||..||...|.:||.|.
Mouse   674 WSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFK 738

  Fly   736 EIIQMLDKLLH-TEMD-YIEL 754
            ::::.||::|. |..| |::|
Mouse   739 QLVEDLDRILTVTSTDEYLDL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	19/108 (18%)
		STYKc	470..741	CDD:214568	123/275 (45%)
		PTKc	474..742	CDD:270623	122/272 (45%)
Fgfr3	NP_001156689.1	IGc2	51..110	CDD:197706	2/15 (13%)
		IG	52..108	CDD:214652	1/13 (8%)
		Ig2_FGFR	155..239	CDD:143265	23/112 (21%)
		IG_like	254..349	CDD:214653	17/104 (16%)
		Ig3_FGFR	262..350	CDD:143175	14/87 (16%)
		PTKc_FGFR3	455..788	CDD:173652	136/339 (40%)
		Pkinase_Tyr	468..744	CDD:285015	123/275 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910