DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Ca and Fgfr2

DIOPT Version :10

Sequence 1:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_034337.2 Gene:Fgfr2 / 14183 MGIID:95523 Length:840 Species:Mus musculus


Alignment Length:758 Identity:218/758 - (28%)
Similarity:347/758 - (45%) Gaps:170/758 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 NQNAPPILYVRERNWRISETEKVGQIIDRVRAEDPDGDDLIFGIEPRFSLPGGENDASPPEKI-- 112
            ||.||        .|  :.|||:.:.:..|.|.:          ..:|..|.|.|.......:  
Mouse   169 NQRAP--------YW--TNTEKMEKRLHAVPAAN----------TVKFRCPAGGNPTPTMRWLKN 213

  Fly   113 --PFQIDRETGVVTLN--------ESLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSSG 167
              .|:.:...|...:.        ||:......|   |..:.:..|.:.|..:...:.||   |.
Mouse   214 GKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN---YTCLVENEYGSINHTYHLDVVER---SP 272

  Fly   168 YRP------QTSISNVVHNISQFLPRF--DQLPGVQSIRNGLPNSRPGGWYPPVPQNNIFGPPPF 224
            :||      ..:.|.||....:|:.:.  |..|.:|             |...|.:|        
Mouse   273 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQ-------------WIKHVEKN-------- 316

  Fly   225 GNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKSRTKLTPITANNSTRVESAIPA 289
            |:.|  .|..:|.::..::......|:|:   ..:.|.:.|.:...:.|.: |.||..:......
Mouse   317 GSKY--GPDGLPYLKVLKAAGVNTTDKEI---EVLYIRNVTFEDAGEYTCL-AGNSIGISFHSAW 375

  Fly   290 ETTTPSGGHHNN-SSSP----ITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAISRTLK 349
            .|..|:...... ::||    |.|:           .:|.|.:|..|:....||         :|
Mouse   376 LTVLPAPVREKEITASPDYLEIAIY-----------CIGVFLIACMVVTVIFCR---------MK 420

  Fly   350 KTKEKEELAKKSNQSQLSS--------TLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIAT 406
            .|.:|.:.:.:....:|:.        |::.:|.:||            |...|..|      .|
Mouse   421 TTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM------------NSNTPLVR------IT 467

  Fly   407 SQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLK 471
            ::||        |:...|               :..|......||:        .:|||||.:|.
Mouse   468 TRLS--------STADTP---------------MLAGVSEYELPED--------PKWEFPRDKLT 501

  Fly   472 FFNILGEGAFGQVWRCEATNINGN--EGITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINV 534
            ....||||.||||...||..|:.:  :...|||||.||:.|||.|..||:||:|:||.:..|.|:
Mouse   502 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI 566

  Fly   535 VHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAK 596
            ::|||.||...|.:||:||.::|.|:.|||:.|   .|..|.........:|..||.|..||:|:
Mouse   567 INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLAR 631

  Fly   597 GMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYD 661
            ||:||.|:..|||||||||:|:|:::..|:||||.|||:.....|::.:.|:||::|||.|:|:|
Mouse   632 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD 696

  Fly   662 NIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSH 726
            .:::.:||:||||:|||||.|||.:|||||...::.:.:::|:|::||.:|..|||.:|..||..
Mouse   697 RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHA 761

  Fly   727 DPQERPLFAEIIQMLDKL--LHTEMDYIELER--------FPD 759
            .|.:||.|.::::.||::  |.|..:|::|.:        :||
Mouse   762 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPD 804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 19/110 (17%)
PTKc 474..742 CDD:270623 124/272 (46%)
Fgfr2NP_034337.2 Ig 50..143 CDD:472250
Ig strand B 77..81 CDD:409353
Ig strand C 88..92 CDD:409353
Ig strand E 109..113 CDD:409353
Ig strand F 123..128 CDD:409353
Ig strand G 136..139 CDD:409353
IgI_2_FGFR 173..267 CDD:409443 19/116 (16%)
Ig strand A 173..176 CDD:409443 2/12 (17%)
Ig strand A' 184..189 CDD:409443 0/4 (0%)
Ig strand B 193..201 CDD:409443 2/7 (29%)
Ig strand C 207..212 CDD:409443 0/4 (0%)
Ig strand C' 215..217 CDD:409443 0/1 (0%)
Ig strand D 226..229 CDD:409443 0/2 (0%)
Ig strand E 233..238 CDD:409443 0/4 (0%)
Ig strand F 247..254 CDD:409443 2/9 (22%)
Ig strand G 257..267 CDD:409443 1/9 (11%)
IgI_3_FGFR2 275..379 CDD:409444 24/130 (18%)
Ig strand A 275..278 CDD:409444 1/2 (50%)
Ig strand A' 282..286 CDD:409444 0/3 (0%)
Ig strand B 294..301 CDD:409444 1/6 (17%)
Ig strand C 305..312 CDD:409444 3/19 (16%)
Ig strand D 327..332 CDD:409444 0/4 (0%)
Ig strand E 344..349 CDD:409444 0/4 (0%)
Ig strand F 357..365 CDD:409444 2/8 (25%)
Ig strand G 368..376 CDD:409444 0/7 (0%)
PTKc_FGFR2 475..787 CDD:270679 138/334 (41%)
Blue background indicates that the domain is not in the aligned region.

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