DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Ca and ros1

DIOPT Version :9

Sequence 1:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_031758565.1	Gene:	ros1 / 101733913	XenbaseID:	XB-GENE-991394	Length:	2240	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	156/540 - (28%)
Similarity:	250/540 - (46%)	Gaps:	106/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 PNIPGV-RGEQSGEEEQPDEEVTPTTPV------RISSTTPKSRTKLTP-ITANNST-------- 281
            |..||| :|:|:..:..|.||...:..:      |.......:.:|  | :||.|.:
Frog  1731 PGKPGVPQGKQNIIQWMPVEEDNGSNIIYYILEYRELHDDDNNESK--PWLTAYNGSCPNICVWE 1793

  Fly   282 --RVESAIPAETTTPSG---GHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRL 341
              .::..........:|   |.::|:|..|..|..|:....:|..:....:.:.:::|:    .|
Frog  1794 AHEIKGTFEFRAAAANGIGLGEYSNTSESIIFFKRKTDVTALVAGILSGILIVLLIVAF----AL 1854

  Fly   342 CAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERDQQMGIAT 406
            ..:|:  :|:::||..|                            ||..      |..:.|.:..
Frog  1855 YWMSK--QKSQKKETTA----------------------------VAIL------EDKELMKLRG 1883

  Fly   407 SQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLK 471
            ...:.|:.||..:...:|:....|...|                              |||.:|.
Frog  1884 LSDAVGLANGCYAVSILPTQKEKEKLPN------------------------------FPREKLT 1918

  Fly   472 FFNILGEGAFGQVWRCEATNINGNE-GITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVV 535
            ....||.||||:|:...|.:|.|.| ||..|||||||..||:.::.:.|.|..:|...: |.|::
Frog  1919 LCVFLGSGAFGEVYEGAAIDILGPETGIKKVAVKTLKRDATDHEKTEFLKEAHLMSQFD-HPNIL 1982

  Fly   536 HLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDY 600
            .|||.|...:|.::|||.::.|.|.||||.:|.:....|.     :|::.||......:::|..|
Frog  1983 KLLGVCLFNEPQYIILELMDGGDLLTYLRGARVDSFTQNP-----LLSTLDLLDISENISRGCAY 2042

  Fly   601 LTSRGIIHRDLAARNILIT------DDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESL 659
            |.....:||||||||.|::      .....|:.|||.|||:.....|.:..||.||:||||.|||
Frog  2043 LEKMHFVHRDLAARNCLVSVKEYNNPSRIVKIGDFGLARDIYKCDYYRKNGEGLLPVRWMAPESL 2107

  Fly   660 YDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCW 724
            .|.||:.:||:|||||::||:.|:|..||||.|..:|:..|:.|.|:..|.:|..::::::..||
Frog  2108 IDGIFTCRSDVWSFGIVLWEVFTMGQQPYPGFSNLEVLHHVQSGQRMCSPTNCPDDVWSLIQKCW 2172

  Fly   725 SHDPQERPLFAEIIQMLDKL 744
            :.||.:||.|:.:.:.|:||
Frog  2173 AQDPWKRPAFSFLQKQLEKL 2192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	110/277 (40%)
		PTKc	474..742	CDD:270623	109/274 (40%)
ros1	XP_031758565.1	FN3	67..>134	CDD:238020
		FN3	166..247	CDD:238020
		FN3	529..631	CDD:238020
		fn3	1037..1112	CDD:394996
		FN3	1537..1636	CDD:238020
		FN3	1637..1726	CDD:238020
		PKc_like	1922..2190	CDD:419665	109/273 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910