DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dan and Tigd5

DIOPT Version :9

Sequence 1:	NP_001262948.1	Gene:	dan / 43023	FlyBaseID:	FBgn0039286	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001119740.1	Gene:	Tigd5 / 300034	RGDID:	1311576	Length:	642	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	154/738 - (20%)
Similarity:	232/738 - (31%)	Gaps:	273/738 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GKRP--------LRSLTPRDKIHAIQRIHDGESKASVARDIGVPESTLRGWCKNEDKLRFMSRQS 65
            |.||        .::.:.:||:.||:|:..||.:|||.||.|||..|||||.|:|.|||:.
  Rat    50 GPRPRVAVKMTFRKAYSIKDKLQAIERVKGGERQASVCRDFGVPGGTLRGWLKDEPKLRWF---- 110

  Fly    66 ATDNLCADALGDKMDGGGGGGGGAGGGGLLGPPEKRQRL------DGA------------LPLN- 111
             .|.|                     ||.:|...|:.||      |.|            :||:
  Rat   111 -LDQL---------------------GGEVGTQRKKMRLANEEEIDRAVYSWFLTLRQHGVPLSG 153

  Fly   112 ---------FSNKLKFDELAFKRSPLNGLDYSTNKNLADLGYNGLPVDYAAFNGGVKAKVFG--- 164
                     |:.::...|..||.|  :|..:...|.                :|....:::|
  Rat   154 PVIQAQAEAFARQIYGPECTFKAS--HGWFWRWQKR----------------HGISSQRIYGEAE 200

  Fly   165 ------ADINRPAADPSLNAI----SPLSSLTHLSGLTGISQSPLAISFNELTTNL--NLLAQLN 217
                  |.:....|.||...:    :| ::|.|..|..|..|     .:|...|.|  .||.:.|
  Rat   201 PPVAGPAPVKEEPAQPSSAGLLLDGTP-ATLPHSEGGYGDEQ-----IYNANVTGLYWRLLPEQN 259

  Fly   218 --PGLAAMSGLNSFPAGAGNLRTPKPSGQTPLQVQSPRSDSGDRSAQGLSVKNWAKQKPGEGQGS 280
              ||                                    :||....|...:.|...:.     :
  Rat   260 ATPG------------------------------------TGDSREPGECSRRWCSDRV-----T 283

  Fly   281 LNLSIKNEGKGGDIKSPSPSIAP---SQMGGPMTLSNLAED--PLLY------WLKSQQTMLGLN 334
            :.|:....|        |..:.|   .|:..|.:|.:..:|  |..|      || |:..:.|.
  Rat   284 VLLAANLTG--------SHKLKPLVIGQLPDPPSLRHHNQDKFPASYRYSPDAWL-SRPLLRGW- 338

  Fly   335 PLYPPTIPMGVTSPPIRSSTPQHMSQLAQTPPIP----SAPLTPSS--TPS-------GSLDE-- 384
             .:...:| ||.....||...|....|...||.|    |.|....|  ||.       ||.:|
  Rat   339 -FFEEFVP-GVKRYLRRSCLQQKAVLLVAHPPCPSWTTSMPAVEESEGTPRQCQPELLGSPEELQ 401

  Fly   385 --KNAAWYNWCKAFGASLHTLNPNAATLAALQANQLQQQVATTAAEGGSMGDPSNILYSHLTKET 447
              ..|....:.....:..|...|....:.|...:..::::...|....| |.|.:.:.|.:.|:.
  Rat   402 TPDGAVRVLFLSRGNSRAHIPAPLEHGVVAAFKHLYKRELLRLAVSCAS-GSPLDFMRSFMLKDM 465

  Fly   448 ETPSVRSLSSNEQNPEADEATETDLDGEVEPEASGKPEDLSAAGKV-----------MTPSQSPI 501
                                          ...:|...||..||.:           ..|.|.|
  Rat   466 ------------------------------LYLAGLSWDLVQAGSIERCWLLGLRAAFEPGQQP- 499

  Fly   502 AHSSGSRSPEPKA------------KTKTPETTNSTSECKKILDNMLFKMGGMEATGPLMPEQGS 554
            ||.....:...:.            |...||   ..:|...:.|:.....|..|...|..|
  Rat   500 AHQVEEAAEHSRMLSDLTHLAALAYKRLAPE---EVAEWLHLDDDGGLPEGCGEEVAPAAP---- 557

  Fly   555 SESEGSFQDTSNPHTNNNDVSASNNNNNNNSNKTDEEEKAK----YLDCTADEDIEAIRHGEKFL 615
                      .:|.:..:.:.|..          :|||:|.    .|..||.|.:..:   |..|
  Rat   558 ----------PSPASLPSSIGAGE----------EEEEEATEQGGVLVPTAGEAVWGL---ETAL 599

  Fly   616 QWLENCSNPRVTAVQLMQLRFLI 638
            :|||:.....|..::|:|||.||
  Rat   600 RWLESQDPREVGPLRLVQLRSLI 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dan	NP_001262948.1	CENP-B_N	10..62	CDD:282122	27/59 (46%)
Tigd5	NP_001119740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		2/3 (67%)
		HTH	62..111	CDD:304362	25/53 (47%)
		HTH_Tnp_Tc5	131..191	CDD:281246	12/77 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..230		5/32 (16%)
		rve	279..485	CDD:304425	47/253 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..583		10/63 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000