DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bili and Frmd8

DIOPT Version :9

Sequence 1:	NP_001163722.1	Gene:	Bili / 43019	FlyBaseID:	FBgn0039282	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_080445.1	Gene:	Frmd8 / 67457	MGIID:	1914707	Length:	466	Species:	Mus musculus

Alignment Length:	456	Identity:	147/456 - (32%)
Similarity:	228/456 - (50%)	Gaps:	63/456 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 GNDAQSNPAIQKRLMATSSTSNFATAGKAASNLTRAL--QNVIPTCVYLMSRVA---VHMEIEGT 447
            ||..|..||      ..|..|:.::.|..|:::...|  ..|:|..|..:|.::   :|..:...
Mouse     6 GNAGQPGPA------ERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLSSISAHELHRAVREV 64

  Fly   448 AQCPSQVMLAAALGCEELGISNKLLAQSVFGLWMTSALLEMQLKAHHCPYIVRVAWPNLLQKFSN 512
            .|.|.                   :|...|.||:.|.|||:|||..|.||.:...||.||.:|:|
Mouse    65 LQLPD-------------------VALEAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTN 110

  Fly   513 SSPSDRKFDEPMIVLKRNVFFSKRDEEKIKDHRILELLYEEARNNVLTGRYIMEPVHSLMLGGIQ 577
            :|..|...|||.:..:|||||.:|.|.:|.|..:|.||||||:.||||.||..:.....:|||:.
Mouse   111 ASDDDVAMDEPSLQFRRNVFFPRRRELQIHDEEVLRLLYEEAKGNVLTARYPCDLEDCEVLGGLV 175

  Fly   578 ARIELGPYNSHTHTIGFFRENQARFLPPHVAKSSTWLWLPI----SQKNSAEVKLLEQFKRVPQT 638
            .|::||||..........||....|||.|:.|....|:...    ::....|..||..:::|.:.
Mouse   176 CRVQLGPYQPGQPAACTLREKLDSFLPAHLCKRGHGLFAAFRGRGAKTGPGEQGLLNAYRQVKEV 240

  Fly   639 --------ATTRKLMRKYLEFCWALPFYGAAYFHGQIEQPVRGIMALVNQKDMEVLVAVNERGVF 695
                    ||.....|.||..|..|||||.|:|||::::|.:|.:....:|  .|.||::..||.
Mouse   241 TGNNSEREATLGSHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRK--PVTVAISLEGVH 303

  Fly   696 VIDPYECTLLLGLRYEDLSWDYAKPSASDDPECLTCIFLQFDAVENGIQVSKLMQIFSKQAAMID 760
            |||..|..:|||||:::||||:..|. .::|    .::|:||....|..|:||::|:||||.::.
Mouse   304 VIDNREKHVLLGLRFQELSWDHTSPE-EEEP----VLWLEFDGDSEGTPVNKLLRIYSKQAELMS 363

  Fly   761 ALISHFTDQIRNKKQEGNTQEPF---HDEPNP---------IQNNGNGVLCNKLSRLTLATFDEE 813
            .|| .:..::....:...:||..   |:.|:|         ::..|: |:|:::..|:...:.|:
Mouse   364 GLI-EYCIELSQAAEPTLSQESASGPHEAPSPSPPPTQRPKLRRQGS-VVCSRIQHLSTIDYVED 426

  Fly   814 G 814
            |
Mouse   427 G 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bili	NP_001163722.1	B41	432..663	CDD:214604	84/245 (34%)
Bili	NP_001163722.1	FERM_M	539..663	CDD:278785	47/135 (35%)
Frmd8	NP_080445.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		6/20 (30%)
		FERM_M	137..273	CDD:366056	47/135 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..409		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..466
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845914
Domainoid	1	1.000	78	1.000	Domainoid score	I8796
eggNOG	1	0.900	-	-		E1_KOG4335
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32653
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004952
OrthoInspector	1	1.000	-	-		oto92517
orthoMCL	1	0.900	-	-		OOG6_108118
Panther	1	1.100	-	-	LDO	PTHR13283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3255
SonicParanoid	1	1.000	-	-		X3494
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780