DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bili and frmd8

DIOPT Version :9

Sequence 1:	NP_001163722.1	Gene:	Bili / 43019	FlyBaseID:	FBgn0039282	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001072175.1	Gene:	frmd8 / 613069	XenbaseID:	XB-GENE-5852953	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	144/447 - (32%)
Similarity:	229/447 - (51%)	Gaps:	51/447 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 NGNDAQSNPAIQKRLMATSSTSNFATAGKAASNLTRALQNVIPTCVYLMSRVAVHMEIEGTAQCP 451
            :|::...:..:...|:.:|.:|.           :|::..:    |||::...:.:.::|.:...
Frog     2 DGSETSHSSGLNDFLLRSSVSSG-----------SRSMDVI----VYLINDEIIQLTVDGLSVIT 51

  Fly   452 SQVM---LAAALGCEELGISNKLLAQSVFGLWMTSALLEMQLKAHHCPYIVRVAWPNLLQKFSNS 513
            :..:   :..||...|       .||.||.||:.|..||:|||..|.||.|...|.:||.:|:|.
Frog    52 AHELHKSIREALQLPE-------TAQDVFALWLISPFLEVQLKPKHQPYKVCRQWHDLLARFTNC 109

  Fly   514 SPSDRKFDEPMIVLKRNVFFSKRDEEKIKDHRILELLYEEARNNVLTGRYIMEPVHSLMLGGIQA 578
            |.:|...|||.:..:||:||.|..|.:|...|.|.||||||:.|||.|||..:.....:|||:..
Frog   110 SSNDILQDEPFLQFRRNIFFPKARELQIAHERTLYLLYEEAKYNVLDGRYPCDVEDCELLGGLAC 174

  Fly   579 RIELGPYNSHTHTIGFFRENQARFLPPHVAKSSTWLWLPISQKN----SAEVKLLEQFKRVPQTA 639
            |:||||||.:.||....|.......||::.|.....:.....|.    |.|..:|..:|.|.:::
Frog   175 RLELGPYNQNEHTPATIRPKLDSLFPPYLCKKRNGFFTTFKNKGGRQASFEQTVLNTYKEVKESS 239

  Fly   640 --TTRKLM----RKYLEFCWALPFYGAAYFHGQIEQPVRGIMALVNQKDMEVLVAVNERGVFVID 698
              |..:.|    |:||:.|..||:||.|:|||.:::|.:|.:....:|  .|.||:|..||.|||
Frog   240 ACTEEQAMKNHYREYLKKCHELPYYGCAFFHGVVDKPAQGFLNRSGRK--PVSVAINLEGVSVID 302

  Fly   699 PYECTLLLGLRYEDLSWDYAKPSASDDPECLTCIFLQFDAVENGIQVSKLMQIFSKQAAMIDALI 763
            ..|..:|:.|.|.:||||:..|   |:.|.:  ::|:||....|..|:||::|:||||.::..||
Frog   303 RKEKHILISLTYPELSWDHTYP---DEEEHI--LWLEFDGDAEGTPVNKLLKIYSKQAELMSGLI 362

  Fly   764 ------SHFTDQIRNKKQEGNTQEPFHDEPNPIQNNGNGVLCNKLSRLTLATFDEEG 814
                  |..|:...:....||:|  ..::.:.::.. ..||||::..|....:.|:|
Frog   363 EYCIELSQTTESPASDFLPGNSQ--LSEKRSKLRRQ-ESVLCNRMKHLNTIDYVEDG 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bili	NP_001163722.1	B41	432..663	CDD:214604	87/243 (36%)
Bili	NP_001163722.1	FERM_M	539..663	CDD:278785	48/133 (36%)
frmd8	NP_001072175.1	FERM_M	136..269	CDD:306805	48/132 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8387
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32653
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1068540at2759
OrthoFinder	1	1.000	-	-		FOG0004952
OrthoInspector	1	1.000	-	-		otm47850
Panther	1	1.100	-	-	LDO	PTHR13283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3255
SonicParanoid	1	1.000	-	-		X3494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.050