DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bili and Krit1

DIOPT Version :9

Sequence 1:	NP_001163722.1	Gene:	Bili / 43019	FlyBaseID:	FBgn0039282	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001102088.1	Gene:	Krit1 / 362317	RGDID:	1305929	Length:	736	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	113/497 - (22%)
Similarity:	186/497 - (37%)	Gaps:	124/497 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 AASGNASCLGGLPDMGANMMSNASALCPLSDLRSPSGVLTNSSYMPQHHKCNNG---------ND 390
            |..|::..|..|.|.|.::                 ..|.|..:.|.|:.|..|         ..
  Rat   296 ACEGDSELLSHLLDKGFSV-----------------NQLDNDHWAPIHYACWYGKVEATRILLEK 343

  Fly   391 AQSNPAIQKRLMATSSTSNFATAG----------------------------------------K 415
            .:.||.:....:  ||..:||..|                                        :
  Rat   344 GKCNPNLLNGQL--SSPLHFAAGGGHSEIVQILLTHPDIDRHITDQQGRSPLNVCEENKQNNWEE 406

  Fly   416 AASNLTRALQNVIPTC-VYLMSRVAVHMEIE-GTAQCPSQVMLAAALGCEELGISNKLLAQSVFG 478
            ||..|..|:....... :|.|......:|:: |......|:|....|..|         .|..|.
  Rat   407 AAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTAQQIMEGMRLSQE---------TQQCFT 462

  Fly   479 LWMTSALLEMQLKAHHCPYIVRVAWPNLLQKFSNSSPSDRKFDEPMIVLKRNVFFSKRDEEKIKD 543
            :|:.|..|.:|.|.:|.|......||.:|.:.:|..|   :.:.|.:.|:|:|......|:||:|
  Rat   463 IWICSENLSLQFKPYHKPLQQVRDWPEILAELTNLDP---QRETPQLFLRRDVGLPLEVEKKIED 524

  Fly   544 HRILELLYEEARNNVLTGRYIMEPVHSLMLGGIQARIELGPYNSHTHTIGFFRENQARFLPPHV- 607
            ...:.:|::|||.|:|.|.|.......:.|..:..:|..|.|.|..|..||..|...:.:.|..
  Rat   525 PLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPITK 589

  Fly   608 --AKSSTWLWLPISQKNSAEVKLLEQFKRVPQTATTRK----LMRKYLEFCWALPFYGAAYFHGQ 666
              :|:..|:           .::|.::|.:..:....|    |.|.:|:.||.:|.||||:|.||
  Rat   590 LKSKAPHWI-----------NRILHEYKNLSMSEGVSKEMHHLQRMFLQNCWEIPTYGAAFFTGQ 643

  Fly   667 I---EQPVRGIMALVNQKDMEVLVAVNERGVFVIDPYECTLLLGLRYEDLSWDYAKPSASDDPEC 728
            |   ..|       .|.|.:.|.|.||.:|:.:::.....||:.|:|...:|...        :.
  Rat   644 IFTKASP-------SNHKVIPVYVGVNIKGLHLLNMETKALLISLKYCCFTWQLG--------DA 693

  Fly   729 LTCIFLQFDAVENGIQVSKLMQIFSKQAAMIDALISHFTDQI 770
            .||  .|..::||.:.    ..:.:|||.::..|:.....|:
  Rat   694 GTC--FQIHSMENKMS----FIVHTKQAGLVVKLLMKLNGQL 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bili	NP_001163722.1	B41	432..663	CDD:214604	63/238 (26%)
Bili	NP_001163722.1	FERM_M	539..663	CDD:278785	36/130 (28%)
Krit1	NP_001102088.1	NUDIX_5	30..198	CDD:406982
		ANK repeat	291..318	CDD:293786	6/38 (16%)
		Ank_2	292..386	CDD:403870	19/108 (18%)
		ANK repeat	320..352	CDD:293786	6/31 (19%)
		ANK repeat	354..386	CDD:293786	5/33 (15%)
		B41	421..640	CDD:214604	63/241 (26%)
		FERM_C_CCM1	636..735	CDD:270018	30/115 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810