DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bili and krit1

DIOPT Version :9

Sequence 1:	NP_001163722.1	Gene:	Bili / 43019	FlyBaseID:	FBgn0039282	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001303930.1	Gene:	krit1 / 321836	ZFINID:	ZDB-GENE-030131-555	Length:	741	Species:	Danio rerio

Alignment Length:	490	Identity:	107/490 - (21%)
Similarity:	183/490 - (37%)	Gaps:	110/490 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 AASGNASCLGGLPDMGANMMSNASALCPLSDLRSPSGVLTNSSYMPQHHKCNNGNDAQSNPAIQK 399
            |..|:...|..|.|.|.::..                 |.:..:.|.|:.|.:|....:...::|
Zfish   294 ACEGDTELLSKLLDGGFSVKQ-----------------LDSDHWAPIHYACWHGKVEATKLLLEK 341

  Fly   400 -----RLM--ATSSTSNFATAGKAASNLTRALQ--------------NVIPTC------------ 431
                 .|:  ..||..:||..|..|..:...||              :.:..|
Zfish   342 GNCNPNLLNGQLSSPLHFAAIGGHAEIVQLLLQHPEIDRHIEDQQKRSPLQVCEENKQNNWEETV 406

  Fly   432 ---------------VYLMSRVAVHMEIE-GTAQCPSQVMLAAALGCEELGISNKLLAQSVFGLW 480
                           :|.|......:|:: |......|:|....|..|         .|..|.:|
Zfish   407 NLLQQASNKPYEKVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQE---------TQQYFTIW 462

  Fly   481 MTSALLEMQLKAHHCPYIVRVAWPNLLQKFSNSSPSDRKFDEPMIVLKRNVFFSKRDEEKIKDHR 545
            :.|..|.:|||.:|.|......|..::   ::.:..|.:.:.|.:.|:|:|......|:|::|..
Zfish   463 ICSENLSLQLKPYHKPLQHLRMWSEIV---TDLTALDPQRESPQLFLRRDVRLPLEVEKKVEDPL 524

  Fly   546 ILELLYEEARNNVLTGRYIMEPVHSLMLGGIQARIELGPYNSHTHTIGFF-RENQARFLPPHVAK 609
            .:.:|::|||:.:|.|.........:.|..:..:|..|.|:|..|..||. .||....:|....|
Zfish   525 SILILFDEARHCLLKGFLSTSDNKLITLASLLLQIIYGNYDSKKHKQGFLNEENLKSIVPISKVK 589

  Fly   610 SSTWLWLPISQKNSAEVKLLEQFKRVPQTATTRK----LMRKYLEFCWALPFYGAAYFHGQIEQP 670
            |....|..         ::|.::|.:..:....|    |.|.:|:.||.:|.||||:|.||:...
Zfish   590 SKAHHWTN---------RILHEYKSLSTSEGVSKEMHHLQRLFLQNCWDIPTYGAAFFTGQVFTK 645

  Fly   671 VRGIMALVNQKDMEVLVAVNERGVFVIDPYECTLLLGLRYEDLSWDYAKPSASDDPECLTCIFLQ 735
            .    :....|.:.|.|.||.:|:.:::.....|.|.|.|....|...:...          ::|
Zfish   646 A----SSSTHKVIRVYVGVNTKGLHLMNMETKVLHLSLEYGTFMWQLGQADQ----------YVQ 696

  Fly   736 FDAVENGIQVSKLMQIFSKQAAMIDALISHFTDQI 770
            ..::||    .|...:.:|||.:|..|:...:.||
Zfish   697 IHSLEN----KKNFVVHTKQAGLIVKLLMKLSGQI 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bili	NP_001163722.1	B41	432..663	CDD:214604	60/236 (25%)
Bili	NP_001163722.1	FERM_M	539..663	CDD:278785	35/128 (27%)
krit1	NP_001303930.1	NUDIX_5	30..197	CDD:293310
		ANK	289..409	CDD:238125	22/131 (17%)
		ANK repeat	289..316	CDD:293786	6/38 (16%)
		Ank_2	290..384	CDD:289560	21/106 (20%)
		ANK repeat	318..350	CDD:293786	6/31 (19%)
		ANK repeat	352..384	CDD:293786	8/31 (26%)
		B41	419..638	CDD:214604	60/239 (25%)
		FERM_M	519..638	CDD:278785	35/127 (28%)
		FERM_C_CCM1	634..733	CDD:270018	28/112 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940