DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bili and frm-10

DIOPT Version :9

Sequence 1:	NP_001163722.1	Gene:	Bili / 43019	FlyBaseID:	FBgn0039282	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001256507.1	Gene:	frm-10 / 179828	WormBaseID:	WBGene00001496	Length:	504	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	124/508 - (24%)
Similarity:	222/508 - (43%)	Gaps:	71/508 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 LSDLRSPSGVLTNSSYMPQHHKCNNGNDAQSNPAIQKRLMATSSTSNFATAGKAASNLTRALQNV 427
            ||:.|:| |:.|..:|   ..|..:|.:......|.:.|.||.:.|. .|.|.         ..|
Worm    20 LSETRNP-GLPTLPNY---GLKDKSGGNIMPWTPIGQALRATHNQST-ETLGS---------PKV 70

  Fly   428 IPTCVYLM--SRVA------VHMEIEGTAQCPSQVMLAAALGCEELGISNKLLAQSVFGLWMTSA 484
            :...:|..  .|::      :.:.||......::.:|...  .:|.||.....:: :|.:||.|.
Worm    71 VKFSIYFSRGERLSNEEENGIELNIESGKTADTKKLLFHL--AKECGIDYSAFSE-MFAIWMISP 132

  Fly   485 LLEMQLKAHHCPYIVRVAWPNLLQKFSNSSPSDRKF---DEPMIVLKRNVFFS-KRDEEKIKDH- 544
            |||:|||::|.||..|..|..||::|:..  :|.:.   |||:::|:||...: .::.|.::||
Worm   133 LLEVQLKSYHRPYECRQGWSTLLERFAKE--TDIQLFNQDEPILMLRRNASLTCDKEFELLQDHP 195

  Fly   545 RILELLYEEARNNVLTGR-YIMEPVHSLMLGGIQARIELGPYNSHTHTIGFFRENQARFLPPHVA 608
            :..:.|..:|...:|.|| :::...:::.:......::.|.::...|.:.|.|.:....||....
Worm   196 KCAKYLIYDASEMLLLGRLHLLSLENTIRVAAFLFCLQFGNFDETRHDVAFIRNHIDEILPERTC 260

  Fly   609 KS---STWLWLPISQKNSAEVKLLEQFKRVPQTATTRKLMRKYL-EFCWALPFYGAAYFHGQIEQ 669
            .|   :|.....|::|...|.:||.::|.:.:.....|.....| |.......||||:|...||.
Worm   261 DSIVATTIFGKAINKKTVQEERLLSEWKNISKIGDKSKKEHDLLMELTQNSSCYGAAWFSAHIEV 325

  Fly   670 PVRGIMALVN----QKDMEVLVAVNERGVFVIDPYECTLLLGLRYEDLSWDYAKPSASDDPECLT 730
            . |...:|.|    ..::||.|.:|:|.:.:::....|||:. ..|:|:|..........|..:
Worm   326 K-RSRASLRNFGHGFAEIEVNVGINDRFLTIVESNSGTLLVH-PLEELTWQLEGLQPDQMPYLI- 387

  Fly   731 CIFLQF-DAVENG----IQVS----KLMQIFSKQAAMIDALISHFTDQIRNK-------KQEGNT 779
             :.|.| :.::||    |.:|    :.:.|...|..:||||:...|.:..::       ..:.:|
Worm   388 -VNLSFEEEIKNGNSTTIDISNETTQFLMITGNQTFLIDALLKTMTGRRLDRSSSDSSSSSDSST 451

  Fly   780 QEPFH----DEPNPIQNNGNGVLCNKLSRLTLATFDEEGGRCIGQMGSLSISY 828
            ....|    :.....:|...|  ||:  :|..|.|.:  |:|....||....|
Worm   452 SSTKHSRIIESKLDFKNCTAG--CNR--KLCFAKFKD--GKCTEVAGSFKAFY 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bili	NP_001163722.1	B41	432..663	CDD:214604	62/248 (25%)
Bili	NP_001163722.1	FERM_M	539..663	CDD:278785	29/129 (22%)
frm-10	NP_001256507.1	B41	72..319	CDD:214604	62/251 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1068540at2759
OrthoFinder	1	1.000	-	-		FOG0004952
OrthoInspector	1	1.000	-	-		oto17971
orthoMCL	1	0.900	-	-		OOG6_108118
Panther	1	1.100	-	-	LDO	PTHR13283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3255
SonicParanoid	1	1.000	-	-		X3494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880