DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clbn and NEMF

DIOPT Version :9

Sequence 1:	NP_001163721.1	Gene:	Clbn / 43018	FlyBaseID:	FBgn0259152	Length:	992	Species:	Drosophila melanogaster
Sequence 2:	NP_004704.3	Gene:	NEMF / 9147	HGNCID:	10663	Length:	1076	Species:	Homo sapiens

Alignment Length:	1118	Identity:	506/1118 - (45%)
Similarity:	684/1118 - (61%)	Gaps:	179/1118 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKTRFNTFDIICGVAELQ-KLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRF 64
            ||:||:|.|:...:|||. .|:|.|||.:|||||||||.|:|....  |.|||:|||.|.|||.|
Human     1 MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDF--KATLLLESGIRIHTTEF 63

  Fly    65 EWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYE 129
            ||||||.||.|:||.|||||::||...:|:|.|||||||||:.:||||:|:|||||||::|||||
Human    64 EWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYE 128

  Fly   130 LTTLYILRPHT-EGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDC 193
            ...|.|||..| |.::::||:||:||::.|:.....|.||.|.:::.:|..|:.|:::|.|.|..
Human   129 YVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPY 193

  Fly   194 GPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQ 258
            |||:|||.||.:|...:|                          :.:.|||.|..:.|  |..||
Human   194 GPALIEHCLLENGFSGNV--------------------------KVDEKLETKDIEKV--LVSLQ 230

  Fly   259 QAVKDAQELIAEGNSGKSKGYIIQVKEEKPT--ENGTVEFFFRNIEFHPYLFIQFKNFEKATFES 321
            :    |::.:...::...||||||.:|.||:  .:..||......||||:||.|........|||
Human   231 K----AEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFES 291

  Fly   322 FMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQS 386
            |.:|||||||..|.||||:|.||||::|||||.||:.||..|||.|.:.|::|:.|.|||..|..
Human   292 FDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQ 356

  Fly   387 LVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPY--DNDED 449
            :||.||:.|:||:|:|:.|.:|..:||||||.||.|||:||:|||:|||::::|.:||  ..:||
Human   357 IVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEED 421

  Fly   450 DDLKDPEVTV------------------------------VDVDLALSAWANARRYYDMKRSAAQ 484
            ||: |.:|.|                              |||||:|||:|||::|||.||.||:
Human   422 DDV-DGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAK 485

  Fly   485 KEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQN 549
            |.:|||:|::||.||||:||:||||||:|:::|.|||||:|||||.|||||||||:|||||.|||
Human   486 KTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQN 550

  Fly   550 ELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWV 614
            |:|||||:.|.||||||::.||:|.:|:|||||.|||:||.|||:||:.||.||||:|:|:::||
Human   551 EIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCYSAAWDARVITSAWWV 615

  Fly   615 TSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDD- 678
            ...||||||||||||.||||||||||||||..:|.||.|.|||:::|.:.||.||||||..::|
Human   616 YHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHQGERKVRVQDEDM 680

  Fly   679 ----QIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRS--D 737
                .....:...|:|.   .|..|..|:.:..|..:..|:      |:..:.|...|.::|  |
Human   681 ETLASCTSELISEEMEQ---LDGGDTSSDEDKEEHETPVEV------ELMTQVDQEDITLQSGRD 736

  Fly   738 SVNPEI--EETKESEVVLDKILKKTD------DE--------ETTIILAGPSRKKQVSAKKTKED 786
            .:|.|:  ||:.|.|...:::.|..|      ||        :|||.|:....::.:....:||:
Human   737 ELNEELIQEESSEDEGEYEEVRKDQDSVGEMKDEGEETLNYPDTTIDLSHLQPQRSIQKLASKEE 801

  Fly   787 ---------------KARAKQEAAKQEVPPVSSE-----------------------PKNPSQV- 812
                           .|:.::|..|:::|..|.:                       .||.:.|
Human   802 SSNSSDSKSQSRRHLSAKERREMKKKKLPSDSGDLEALEGKDKEKESTVHIETHQNTSKNVAAVQ 866

  Fly   813 --KRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVK--PEKS 873
              |||||.|:||||:||||||:|:||:.|.:|.|:|..|.:..  |..:|.::..|.||  |:|.
Human   867 PMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGSAGSNKEEKG--KKGKKGKTKDEPVKKQPQKP 929

  Fly   874 AA-----------------------------PKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDE 909
            ..                             |.:..|..|.|:  .|.:.::.:|||||||..|.
Human   930 RGGQRVSDNIKKETPFLEVITHELQDFAVDDPHDDKEEQDLDQ--QGNEENLFDSLTGQPHPEDV 992

  Fly   910 LLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLAR 974
            ||||||:.|||..:.|||:|||||||..|:|||||.|||.|...|..:||||||.:|:|:..|:|
Human   993 LLFAIPICAPYTTMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSR 1057

  Fly   975 NIPGKVKLSAPQL 987
            |||||||:|||.|
Human  1058 NIPGKVKVSAPNL 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clbn	NP_001163721.1	YloA	1..643	CDD:224212	355/677 (52%)
		DUF814	531..630	CDD:283353	70/98 (71%)
		DUF3441	883..984	CDD:288752	58/100 (58%)
NEMF	NP_004704.3	YloA	1..644	CDD:224212	355/677 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..453		7/33 (21%)
		ASF1_hist_chap	<658..776	CDD:328900	33/126 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..715		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..972		56/231 (24%)
		DUF3441	968..1067	CDD:314748	58/100 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146568
Domainoid	1	1.000	434	1.000	Domainoid score	I580
eggNOG	1	0.900	-	-		E1_COG1293
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3458
Inparanoid	1	1.050	849	1.000	Inparanoid score	I435
Isobase	1	0.950	-	0	Normalized mean entropy	S2364
OMA	1	1.010	-	-		QHG54163
OrthoDB	1	1.010	-	-		D131285at2759
OrthoFinder	1	1.000	-	-		FOG0005262
OrthoInspector	1	1.000	-	-		oto89302
orthoMCL	1	0.900	-	-		OOG6_101297
Panther	1	1.100	-	-	LDO	PTHR15239
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4285
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.720