Protein Alignment Clbn and rqc2

DIOPT Version :10

• Sequence 1: NP_651341.2
• Gene: Clbn / 43018
• FlyBaseID: FBgn0259152
• Length: 992
• Species: Drosophila melanogaster
• Sequence 2: NP_588145.2
• Gene: rqc2 / 2538747
• PomBaseID: SPCC132.01C
• Length: 1021
• Species: Schizosaccharomyces pombe
• Alignment Length: 1096
• Identity: 340/1096 - (31%)
• Similarity: 539/1096 - (49%)
• Gaps: 215/1096 - (19%)

  Fly     1 MKTRFNTFDIICGVAEL-QKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRF 64
            ||.||:..||....||| :::||.|:|..||::.:|:|.:.....|  |.:::||||.|.|.|:|
pombe     1 MKQRFSALDIAAIAAELREQVVGCRLNNFYDLNARTFLLKFGKQDA--KYSIVIESGFRAHLTKF 63

  Fly    65 EWPKNMAP-SGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTG------DAAYHVILELYDRGN 122
            :  :..|| |||..|||||:|::||..|.|:|:||::.|.||.|      |..|:::.|.:..||
pombe    64 D--RENAPLSGFVTKLRKHIKSRRLTGVSQLGTDRVLVFTFGGGANDQDPDWTYYLVCEFFAAGN 126

  Fly   123 VILTDYELTTLYILR---------------------------------PHTEGENLRF------- 147
            |:|.|.....|.:||                                 ||...|.|..
pombe   127 VLLLDGHYKILSLLRVVTFDKDQVYAVGQKYNLDKNNLVNDNKSQSTIPHMTAERLNILLDEIST 191

  Fly   148 ------AMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNL-DCGPAVIEHVLLSH 205
                  ::.|..|.::....||.:::...|.          ||:.||..| :.|.|:|||.|...
pombe   192 AYASPTSINEPLPDQQLSSSTKPIKVPKPVS----------LRKALTIRLGEYGNALIEHCLRRS 246

  Fly   206 GLDN-----HVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQ 265
            .||.     .:...||                   ||              ||   |..|.::|.
pombe   247 KLDPLFPACQLCADET-------------------KK--------------ND---LLAAFQEAD 275

  Fly   266 ELIAEGNSGKSKGYIIQVKE--------EKPTENGTVEFFFRNIEFHPYLFIQF--KNFEKATFE 320
            .::|..|....||||..:::        :.|.|..|:     ..:|||:..:|.  .|.:...|.
pombe   276 SILAAVNKPPVKGYIFSLEQALTNAADPQHPEECTTL-----YEDFHPFQPLQLVQANRKCMEFP 335

  Fly   321 SFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQ 385
            ::.|.||||:|:.|:||:..:...:...|.::|.:.|.|.|::|:.|...|.....:|:.|..|.
pombe   336 TYNECVDEFFSSIEAQKLKKRAHDRLATAERRLESAKEDQARKLQSLQDAQATCALRAQAIEMNP 400

  Fly   386 SLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIK-QLKLETNHISLMLSDPY----- 444
            .||:..|..:.|.:...:.|.||.:|: ::|.....||::|: .|||..|.:::.|.:|.
pombe   401 ELVEAIISYINSLLNQGMDWLDIEKLI-QSQKRRSPVAAAIQIPLKLIKNAVTVFLPNPESVDNS 464

  Fly   445 ------------DNDEDDDLKDPEVT----VVDVDLALSAWANARRYYDMKRSAAQKEKKTVDAS 493
                        |:|:|:.:|:.:|:    .|::||:|.|:||||:.|:::|.|..||.||.:|:
pombe   465 DESSETSDDDLDDSDDDNKVKEGKVSSKFIAVELDLSLGAFANARKQYELRREALIKETKTAEAA 529

  Fly   494 QKALKSAERKTQQTLKEVRT--ISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRY 556
            .|||||.:||.:|.||...|  ...|:..||.|:||||:||||||.|||:||||||||||:.::|
pombe   530 SKALKSTQRKIEQDLKRSTTADTQRILLGRKTFFFEKFHWFISSEGYLVLGGRDAQQNELLFQKY 594

  Fly   557 MRPKDIYVHAEIQGASSVIIQNPTGEE-IPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVS 620
            ....||:|.|::..:|.:|::|....: |||.||.:|||:|::.|.|||:|.|.:::||..|:||
pombe   595 CNTGDIFVCADLPKSSIIIVKNKNPHDPIPPNTLQQAGSLALASSKAWDSKTVISAWWVRIDEVS 659

  Fly   621 KTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVK 685
            |.|||||.|.||||.||.|||:||...|.||..:|::|::...||    ||.|.||.:.::...|
pombe   660 KLAPTGEILPTGSFAIRAKKNYLPPTVLIMGYGILWQLDEKSSER----RKARRLEMEVVETQGK 720

  Fly   686 ENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESE 750
            .:|::.:                   .|.:|    :|..|:.....:....|:.|....:|..|:
pombe   721 VSELKME-------------------GTSVT----SEDNIQDVVSEVSYNEDTNNQSTPDTTGSD 762

  Fly   751 VVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQE--VPPVSSEPKNPSQVK 813
            :.:  :.:|...:.:.:|.|     |:||||:.:|.: ||:::.|.:|  ..|:|.|.....|..
pombe   763 IHI--VSEKRGKKGSKVITA-----KKVSAKERREAR-RARRQTALEESLKAPISIEDATDPQTI 819

  Fly   814 RGQKGKLKKMKQKYKDQDDEEREIRMMILK--SSGKEKPQASAD------------KVVE----- 859
            .... |.||.|:|:..:   |.||...|..  ||..:.|.|.::            :|:|
pombe   820 LAIL-KQKKAKKKHAAR---EMEISSQIPSNDSSNVQTPTAESEIEEDGVSEPISAEVIEDQSRN 880

  Fly   860 -KSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDV---LNSLTGQPHEGDELLFAIPVVAPY 920
             ::|:.|.....::.......||.....|:|.....::   ::|||..|.:.|.::.|:|..|||
pombe   881 SEAENEKGLSTEQRDEKKHAKVESFQRQEMPRSLFEEIFFAIDSLTPNPQQQDTVINAVPTFAPY 945

  Fly   921 QALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNI 976
            .|:..:..|||:.|||||.||||:.::..|.|:...|::|...|:::|:..:...|
pombe   946 NAMTKFNQKVKVMPGTGKVGKAARESIAYFMKKLPKSSKEAAYLENLKDGEIVAPI 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clbn	NP_651341.2	RqcH_arch	8..643	CDD:469043	244/729 (33%)
		PTZ00341	<654..>814	CDD:173534	36/161 (22%)
		NFACT-C	893..983	CDD:432191	30/87 (34%)
rqc2	NP_588145.2	RqcH_arch	6..682	CDD:469043	244/731 (33%)
		NFACT-C	922..1009	CDD:432191	30/80 (38%)