DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clbn and SPCC132.01c

DIOPT Version :9

Sequence 1:	NP_001163721.1	Gene:	Clbn / 43018	FlyBaseID:	FBgn0259152	Length:	992	Species:	Drosophila melanogaster
Sequence 2:	NP_588145.2	Gene:	SPCC132.01c / 2538747	PomBaseID:	SPCC132.01c	Length:	1021	Species:	Schizosaccharomyces pombe

Alignment Length:	1096	Identity:	340/1096 - (31%)
Similarity:	539/1096 - (49%)	Gaps:	215/1096 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKTRFNTFDIICGVAEL-QKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRF 64
            ||.||:..||....||| :::||.|:|..||::.:|:|.:.....|  |.:::||||.|.|.|:|
pombe     1 MKQRFSALDIAAIAAELREQVVGCRLNNFYDLNARTFLLKFGKQDA--KYSIVIESGFRAHLTKF 63

  Fly    65 EWPKNMAP-SGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTG------DAAYHVILELYDRGN 122
            :  :..|| |||..|||||:|::||..|.|:|:||::.|.||.|      |..|:::.|.:..||
pombe    64 D--RENAPLSGFVTKLRKHIKSRRLTGVSQLGTDRVLVFTFGGGANDQDPDWTYYLVCEFFAAGN 126

  Fly   123 VILTDYELTTLYILR---------------------------------PHTEGENLRF------- 147
            |:|.|.....|.:||                                 ||...|.|..
pombe   127 VLLLDGHYKILSLLRVVTFDKDQVYAVGQKYNLDKNNLVNDNKSQSTIPHMTAERLNILLDEIST 191

  Fly   148 ------AMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNL-DCGPAVIEHVLLSH 205
                  ::.|..|.::....||.:::...|.          ||:.||..| :.|.|:|||.|...
pombe   192 AYASPTSINEPLPDQQLSSSTKPIKVPKPVS----------LRKALTIRLGEYGNALIEHCLRRS 246

  Fly   206 GLDN-----HVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQ 265
            .||.     .:...||                   ||              ||   |..|.::|.
pombe   247 KLDPLFPACQLCADET-------------------KK--------------ND---LLAAFQEAD 275

  Fly   266 ELIAEGNSGKSKGYIIQVKE--------EKPTENGTVEFFFRNIEFHPYLFIQF--KNFEKATFE 320
            .::|..|....||||..:::        :.|.|..|:     ..:|||:..:|.  .|.:...|.
pombe   276 SILAAVNKPPVKGYIFSLEQALTNAADPQHPEECTTL-----YEDFHPFQPLQLVQANRKCMEFP 335

  Fly   321 SFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQ 385
            ::.|.||||:|:.|:||:..:...:...|.::|.:.|.|.|::|:.|...|.....:|:.|..|.
pombe   336 TYNECVDEFFSSIEAQKLKKRAHDRLATAERRLESAKEDQARKLQSLQDAQATCALRAQAIEMNP 400

  Fly   386 SLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIK-QLKLETNHISLMLSDPY----- 444
            .||:..|..:.|.:...:.|.||.:|: ::|.....||::|: .|||..|.:::.|.:|.
pombe   401 ELVEAIISYINSLLNQGMDWLDIEKLI-QSQKRRSPVAAAIQIPLKLIKNAVTVFLPNPESVDNS 464

  Fly   445 ------------DNDEDDDLKDPEVT----VVDVDLALSAWANARRYYDMKRSAAQKEKKTVDAS 493
                        |:|:|:.:|:.:|:    .|::||:|.|:||||:.|:::|.|..||.||.:|:
pombe   465 DESSETSDDDLDDSDDDNKVKEGKVSSKFIAVELDLSLGAFANARKQYELRREALIKETKTAEAA 529

  Fly   494 QKALKSAERKTQQTLKEVRT--ISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRY 556
            .|||||.:||.:|.||...|  ...|:..||.|:||||:||||||.|||:||||||||||:.::|
pombe   530 SKALKSTQRKIEQDLKRSTTADTQRILLGRKTFFFEKFHWFISSEGYLVLGGRDAQQNELLFQKY 594

  Fly   557 MRPKDIYVHAEIQGASSVIIQNPTGEE-IPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVS 620
            ....||:|.|::..:|.:|::|....: |||.||.:|||:|::.|.|||:|.|.:::||..|:||
pombe   595 CNTGDIFVCADLPKSSIIIVKNKNPHDPIPPNTLQQAGSLALASSKAWDSKTVISAWWVRIDEVS 659

  Fly   621 KTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVK 685
            |.|||||.|.||||.||.|||:||...|.||..:|::|::...||    ||.|.||.:.::...|
pombe   660 KLAPTGEILPTGSFAIRAKKNYLPPTVLIMGYGILWQLDEKSSER----RKARRLEMEVVETQGK 720

  Fly   686 ENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESE 750
            .:|::.:                   .|.:|    :|..|:.....:....|:.|....:|..|:
pombe   721 VSELKME-------------------GTSVT----SEDNIQDVVSEVSYNEDTNNQSTPDTTGSD 762

  Fly   751 VVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQE--VPPVSSEPKNPSQVK 813
            :.:  :.:|...:.:.:|.|     |:||||:.:|.: ||:::.|.:|  ..|:|.|.....|..
pombe   763 IHI--VSEKRGKKGSKVITA-----KKVSAKERREAR-RARRQTALEESLKAPISIEDATDPQTI 819

  Fly   814 RGQKGKLKKMKQKYKDQDDEEREIRMMILK--SSGKEKPQASAD------------KVVE----- 859
            .... |.||.|:|:..:   |.||...|..  ||..:.|.|.::            :|:|
pombe   820 LAIL-KQKKAKKKHAAR---EMEISSQIPSNDSSNVQTPTAESEIEEDGVSEPISAEVIEDQSRN 880

  Fly   860 -KSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDV---LNSLTGQPHEGDELLFAIPVVAPY 920
             ::|:.|.....::.......||.....|:|.....::   ::|||..|.:.|.::.|:|..|||
pombe   881 SEAENEKGLSTEQRDEKKHAKVESFQRQEMPRSLFEEIFFAIDSLTPNPQQQDTVINAVPTFAPY 945

  Fly   921 QALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNI 976
            .|:..:..|||:.|||||.||||:.::..|.|:...|::|...|:::|:..:...|
pombe   946 NAMTKFNQKVKVMPGTGKVGKAARESIAYFMKKLPKSSKEAAYLENLKDGEIVAPI 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clbn	NP_001163721.1	YloA	1..643	CDD:224212	248/736 (34%)
		DUF814	531..630	CDD:283353	53/99 (54%)
		DUF3441	883..984	CDD:288752	32/97 (33%)
SPCC132.01c	NP_588145.2	YloA	1..682	CDD:224212	248/736 (34%)
		YloA	375..981	CDD:224212	216/645 (33%)
		DUF814	569..651	CDD:283353	42/81 (52%)
		DUF3441	921..1010	CDD:288752	30/81 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	194	1.000	Domainoid score	I705
eggNOG	1	0.900	-	-		E1_COG1293
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3458
Inparanoid	1	1.050	423	1.000	Inparanoid score	I340
OMA	1	1.010	-	-		QHG54163
OrthoFinder	1	1.000	-	-		FOG0005262
OrthoInspector	1	1.000	-	-		oto100913
orthoMCL	1	0.900	-	-		OOG6_101297
Panther	1	1.100	-	-	LDO	PTHR15239
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1916
SonicParanoid	1	1.000	-	-		X4285
TreeFam	1	0.960	-	-
	14	13.860