DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vig2 and Serbp1

DIOPT Version :9

Sequence 1:	NP_733083.1	Gene:	vig2 / 43016	FlyBaseID:	FBgn0046214	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_080090.2	Gene:	Serbp1 / 66870	MGIID:	1914120	Length:	407	Species:	Mus musculus

Alignment Length:	403	Identity:	122/403 - (30%)
Similarity:	170/403 - (42%)	Gaps:	108/403 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 NRYELLFMDDDD----------------SSGLAQPQIAAVVAAPKKPEPAKAPKAPKSKSEKENK 86
            ||::.||.|:.|                ..|:..|...:...|..:.....|.|..:.:|:|:.|
Mouse    15 NRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRK 79

  Fly    87 -PV-----VAARK--ANAPVAKNASPVKGGKGPAGGDVGRPKNPTANGANN------QGRFNNNQ 137
             |:     ||.:|  ...|||.....::        .|||..:....|...      :.|....:
Mouse    80 NPLPPSVGVADKKEETQPPVALKKEGIR--------RVGRRPDQQLQGDGKLIDRRAERRPPRER 136

  Fly   138 RY----GNKESNGEFGNELP--QRQFNNRDNRGPPR------VRTGEKF---GKREFDRQSGSDR 187
            |:    ..|...|||..:.|  :|....|...|..|      :..|:.|   |||||||.|||||
Mouse   137 RFEKPLEEKGEGGEFSVDRPIIERPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDR 201

  Fly   188 ------TGVKSIDKREGGGAHNWG--------SPK----------QDIEDLKTT-----GETSPQ 223
                  :|:|..|||.|.|:||||        |||          .|::....|     ||..|.
Mouse   202 SSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLDQSNVTEETPEGEEHPV 266

  Fly   224 AEKEDSANEQSADPAVAAEEDESKQMTLDEWKALRDQ-RAKPNYNLRKAGEGAADNAEWKKMIVL 287
            |:.|:..||     ....:|:..|:||||||||:::: |||..:|:||..|||  :.:|||..||
Mouse   267 ADTENKENE-----VEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGA--DGQWKKGFVL 324

  Fly   288 --SKKKESNSEDELEYDPSLYPQRVGRLQRIVDIQFNFNDGRKVGFRKGPRPGAGPREGGFRNDG 350
              ||.:|:::||.:.......|......|    ::.||.|   :|     |||.|.|.|    .|
Mouse   325 HKSKSEEAHAEDSVMDHHFRKPANDITSQ----LEINFGD---LG-----RPGRGGRGG----RG 373

  Fly   351 PRGEGGYRNDGPR 363
            .||.||..|.|.|
Mouse   374 GRGRGGRPNRGSR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vig2	NP_733083.1	HABP4_PAI-RBP1	175..273	CDD:282609	51/127 (40%)
Serbp1	NP_080090.2	IHABP4_N	5..119	CDD:292792	24/111 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..227		55/201 (27%)
		HABP4_PAI-RBP1	189..312	CDD:282609	51/127 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..288		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..407		25/76 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837161
Domainoid	1	1.000	79	1.000	Domainoid score	I8639
eggNOG	1	0.900	-	-		E1_KOG2945
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4516
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48663
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002116
OrthoInspector	1	1.000	-	-		mtm8776
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12299
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5307
SonicParanoid	1	1.000	-	-		X1570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890