DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vig2 and serbp1a

DIOPT Version :9

Sequence 1:	NP_733083.1	Gene:	vig2 / 43016	FlyBaseID:	FBgn0046214	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	XP_009300781.1	Gene:	serbp1a / 335449	ZFINID:	ZDB-GENE-030131-7389	Length:	392	Species:	Danio rerio

Alignment Length:	456	Identity:	132/456 - (28%)
Similarity:	180/456 - (39%)	Gaps:	130/456 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 NRYELLFMDDDD-----SSGLAQPQIAAVVAAPKKPEPAKAPKAPKSKSEKENKPVVAARK---- 93
            ||::.||.|::|     .....:.:.|.|..|.|  ..|:|.|.||.:|:||.:..:..:|
Zfish    15 NRFDQLFDDEEDPFEVLKQAEKKKKDATVPGAAK--TAAQAAKQPKKESQKERRNPLPDKKEETQ 77

  Fly    94 ANAPVAKNASPVKGGKGPAGGDVGRPKN------PTANGANNQGRFNNNQRYGNK---------- 142
            |..|:.|:.....|.:....|..|..:.      |.......:||...::|...:
Zfish    78 APVPLKKDGMRKMGRRPEQQGQQGSQQQQQQQQVPQQQAGQGEGRPPADRRPDRRPPRERRFDKP 142

  Fly   143 -----ESNGEFGNE--LPQRQFNNRD---------NRGPPRVRTGEKFGKREFDRQSGSDRTGVK 191
                 ...|||..|  :..|.|..|.         .||..|....:..|||||||.|||||:.:|
Zfish   143 ADEKPAEGGEFSVEKTMGDRPFRGRGGPRGGRGGRGRGVGRTDGFDSRGKREFDRHSGSDRSSLK 207

  Fly   192 SIDKREGGGAHNWGSPKQDIEDLKTT--------GETSPQAEKEDSANEQSADPAVAAEEDESKQ 248
            :.:||.|.|:||||:.|.::.:|..:        ||..|.|:.|:..||     ...|:|:..|:
Zfish   208 AEEKRGGSGSHNWGTVKDELSELDQSNVTEDTPEGEEHPPADSENKENE-----VEEAKEEGPKE 267

  Fly   249 MTLDEWKALRD-QRAKPNYNLRKAGEGAADNAEWKKMIVLSKKK-ESNSEDELEYDPSLYPQRVG 311
            |:||||||.:| :|||..:|:|||.||    |:|||..||.|.| |..|.|:...|   :..|..
Zfish   268 MSLDEWKAQQDKERAKVEFNIRKANEG----ADWKKGYVLHKSKAEDASADDAAGD---HHFRKP 325

  Fly   312 RLQRIVDIQFNFNDGRKVGFRKGPRPGAGPREGGFRNDGPRGEGGYRNDGPRGEGGYRNDGPRGE 376
            .......::.||.|   :|     |||.|       ..||||          |.||      ||.
Zfish   326 ANDITSQLEINFGD---LG-----RPGRG-------RGGPRG----------GRGG------RGA 359

  Fly   377 GPRNEGPRGEGYRNDGPRGEGFRGPRFNNGPSNGYENRQDNNRFGEKRRSAQKPLKVDDEAQFPT 441
            ......||                           |.|.|      |......| .|||...||.
Zfish   360 AAATRPPR---------------------------ERRPD------KVGGVSVP-NVDDPEAFPA 390

  Fly   442 L 442
            |
Zfish   391 L 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vig2	NP_733083.1	HABP4_PAI-RBP1	175..273	CDD:282609	48/106 (45%)
serbp1a	XP_009300781.1	IHABP4_N	5..95	CDD:292792	23/81 (28%)
serbp1a	XP_009300781.1	HABP4_PAI-RBP1	191..293	CDD:282609	48/106 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580734
Domainoid	1	1.000	97	1.000	Domainoid score	I7158
eggNOG	1	0.900	-	-		E1_KOG2945
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4255
OMA	1	1.010	-	-		QHG48663
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002116
OrthoInspector	1	1.000	-	-		mtm6592
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12299
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5307
SonicParanoid	1	1.000	-	-		X1570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890