Protein Alignment TTLL5 and TTLL4

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_016860876.1
• Gene: TTLL4 / 9654
• HGNCID: 28976
• Length: 1226
• Species: Homo sapiens
• Alignment Length: 848
• Identity: 235/848 - (27%)
• Similarity: 364/848 - (42%)
• Gaps: 192/848 - (22%)

  Fly     8 ALTNSSISFDYQKEDDWITS-GKLGS-------REAVLVFRTNILNPKIRKTLSEKSSAQVLTDT 64
            ||.:||.|.|..||..:..: .||.:       |:...:.:::.|||..:..:..:|
Human   320 ALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQSSFLNPSFQWNVLNRS-------- 376

  Fly    65 KDNEEKPVQSPQKLAEEEPTSSE---PSSKEALSGSTQQKIFLLKK---------------PQQC 111
              ...||....|:..:|:..|..   |.:.:.|  .....:|..|:               ...|
Human   377 --RRWKPPAVNQQFPQEDAGSVRRVLPGASDTL--GLDNTVFCTKRISIHLLASHASGLNHNPAC 437

  Fly   112 DK-SDKLTFSS------PFKKIL------NRYSSSDTSISSEGEEPANSSENKSRVLKTSQNAIN 163
            :. .|...|..      ||.:.|      .|.||.... .||.|.|     .::|.|.:|..  :
Human   438 ESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSIQLG-QSEKERP-----EEARELDSSDR--D 494

  Fly   164 IKLATDLSNESGYESIAPAKTISNTE-VIEEDQEETSEDDAECG--------------------- 206
            |..||||..:.........:.:...| ....|:.|..|.|:||.
Human   495 ISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEEGDSECSSLSAVSPSESVAMISRSCMEI 559

  Fly   207 INMPAS------KLKITY--------------------KFHQTETKLLR-KLFNV---------- 234
            :..|.|      :..:.|                    |....:.|||| |:..|
Human   560 LTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIG 624

  Fly   235 HGLTEVQGENNNFNLLWTGVHMKLDIVRNLAPYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMK 299
            ....::...|:::...| |.|||....|::..:|::||||.|:::.|||||::|:.|||...|.|
Human   625 RSHFKISKRNDDWLGCW-GHHMKSPSFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKK 688

  Fly   300 HFDIVPQTFVLPIESRDLVVA-HNKHRGPWIVKPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIV 363
            .|...||:|:||.:::.|..| .:..|..|||||.||:||.||.:::...|:|:....:|.:|:.
Human   689 EFSFFPQSFILPQDAKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLH 753

  Fly   364 DPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEGIVRLATVKYDRHADNLWNPCMHLCNYSINKYHS 428
            .|..|.|.|.|||:||.|||:|||.|||:.:|:||.|:.||.....:|.|..|||.|||:||.::
Human   754 KPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNA 818

  Fly   429 DYIRSSDAQDEDVGHKWTLSALLRHLKLQSCDTRQLMLNIEDLIIKAVLACAQSIISACRMFVPN 493
            :|..::| :....||||.|.||..:|..:..::..:...|:|:::|.:::....:.|..:|:|..
Human   819 EYQANAD-EMACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRR 882

  Fly   494 GNNCFELYGFDILIDNALKPWLLEINLSPSMGVDSPLDTKVKSCLMADLLTCVG--IPAYSPEMK 556
            ..:|.||:||||::|..||||:||:|:|||:...||||..:|..::.|||...|  :|.....:.
Human   883 PYSCHELFGFDIMLDENLKPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIIS 947

  Fly   557 SHYDQKWSRFRSSSCQ--------------RIATFPSTSQKTKKS---------KKKGAAINLNL 598
            |          .|||.              |:|....|:||.||:         :...|::...|
Human   948 S----------PSSCSSSTTSLPTSPGDKCRMAPEHVTAQKMKKAYYLTQKIPDQDFYASVLDVL 1002

  Fly   599 TGEEQRILRNARLQYSRRGGFVRIFPTDDSMQRYGNFLDSANGIPISTPNVQSQTFQTPIIQHNY 663
            |.::.|||.....::||||.|.||||:..| .||..|                           :
Human  1003 TPDDVRILVEMEDEFSRRGQFERIFPSHIS-SRYLRF---------------------------F 1039

  Fly   664 NQMLHQNLYSKDGRQKQDDNN----EADRIWQYE---RALETDSEIPFVKKPTVEKCEVEGRRLR 721
            .|..:.|:.:....||...|.    :..|.|.|:   ..:.:|| .|.|...:||.....|..|.
Human  1040 EQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDS-APVVSAASVEDSSFSGPSLL 1103

  Fly   722 KIM 724
            .:|
Human  1104 CLM 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	118/285 (41%)
TTLL4	XP_016860876.1	TTL	654..946	CDD:397308	119/292 (41%)