Protein Alignment TTLL5 and Ttll7

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001289886.1
• Gene: Ttll7 / 70892
• MGIID: 1918142
• Length: 912
• Species: Mus musculus
• Alignment Length: 753
• Identity: 198/753 - (26%)
• Similarity: 326/753 - (43%)
• Gaps: 185/753 - (24%)

  Fly   204 ECGINMPASKLK----ITYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVHMKLDIVRNL 264
            :|.:.....|.|    ||.....|:.:::|.:.:..|..:...|:...||:|....::.:.:.:|
Mouse    25 QCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDL 89

  Fly   265 APYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKHFDIVPQTFVLPIE---SRDLVVAHNKHR- 325
            ..|||:||||...|:.|||.|.:|:.:|...|.| .:..||:|::.|.|   .::.|....|.|
Mouse    90 QNYQRINHFPGMGEICRKDFLARNMTKMIKSRPM-DYTFVPRTWIFPSEYTQFQNYVKELKKKRK 153

  Fly   326 -GPWIVKPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLII 389
             ..:|||||..:.|.||.::.:.|::|..:..:|.:||..|..::|:|.|||:|:||||.|||.|
Mouse   154 QKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKI 218

  Fly   390 YLYEEGIVRLATVKY-DRHADNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDVGHKWTLSALLRH 453
            :||.:|:||:.|.|| ..:..||....|||.|||:||::..:.|:   :.||.|.|.::......
Mouse   219 FLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERN---ETEDKGSKRSIKWFTEF 280

  Fly   454 LKLQSCDTRQLMLNIEDLIIKAVLACAQSIISA---CRMFVPNGNN--CFELYGFDILIDNALKP 513
            |:....|..:...:|.:|::|.::.....::.|   ||...|.|:.  |||:.|||||:|..|||
Mouse   281 LQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKP 345

  Fly   514 WLLEINLSPSMGVDSPLDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQKWSRFR----SSSCQRI 574
            ||||||.:||.|.|..:|..||..::.:.|..:.|.. |.:.|:...||....|    .:..:|:
Mouse   346 WLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRT-SDKRKNLAKQKAEAQRRLYGQNPVRRL 409

  Fly   575 ATFPSTS----QKTKKSKKKGAAINLNLTGEE--QRILRNARLQYSRR-------GGFVRIFPTD 626
            :  |.:|    |:.:..::|          ||  :|:|: .|.|.|:.       |.:.||:|.:
Mouse   410 S--PGSSDWEQQRHQLERRK----------EELKERLLQ-VRKQVSQEEHENRHMGNYRRIYPPE 461

  Fly   627 DS--MQRYGNFLDSANGIPISTPNVQSQTF---QTPIIQHNYNQML------------------H 668
            |.  :::|...|           .|..|||   :....|...|..|                  .
Mouse   462 DKALLEKYEGLL-----------AVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDD 515

  Fly   669 QNLYSKDGR-----------------QKQDDNNEADRIWQYERALETDSEIPFVKKPTVEKCEVE 716
            :.|..|.||                 :||.....:|..:. ..:..::||:...:|   |.|:
Mouse   516 EKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYD-SSSSSSNSELDENEK---ELCQ-- 574

  Fly   717 GRRLRKIMLKKISNGSELTPFQARQTFSMYLESVLRRLTEDPKDNHEKI---------ILKFLNK 772
             :||.::            |:..:.|...       ::.:....:|..|         .|.||::
Mouse   575 -KRLDQV------------PYSLKHTSHC-------KIIQQSSGSHNLIYSESPVYLTTLVFLSE 619

  Fly   773 F--------------------GGSVKPPVMFRNMQTIKVASKARSAMVAKLLGDFLENYKRDTEA 817
            |                    .|.|:|   |.:.|.|.:|                    |.|.|
Mouse   620 FPDSMRRSVSCPRSISAHLPSRGDVRP---FSSQQVIPLA--------------------RPTSA 661

  Fly   818 YVDSFDHFGMIPSSAYNQFLMHAQESDLEAVLTLHTNV 855
               |..| .:..:|:|.:.|.|.  ||..:..||:.::
Mouse   662 ---SRSH-SLNRASSYARHLPHG--SDTGSTNTLNESL 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	111/293 (38%)
Ttll7	NP_001289886.1	TTL	91..376	CDD:397308	110/288 (38%)
		YhaN	<384..>474	CDD:443752	23/113 (20%)
		c-MTBD region. /evidence=ECO:0000250|UniProtKB:Q6ZT98	388..450		15/74 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..570		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..688		10/35 (29%)