Protein Alignment TTLL5 and TTLL13

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001382946.1
• Gene: TTLL13 / 440307
• HGNCID: 32484
• Length: 751
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 234/807 - (28%)
• Similarity: 354/807 - (43%)
• Gaps: 152/807 - (18%)

  Fly   133 SDTSISSEGEEPANSSENKSRVLKTSQNAI-----NIKLATDLSNESGYESIAPAKTIS--NTEV 190
            |:..:......|:|||:  ..:||....|:     :..:||.:          |.|.|:  :|..
Human    21 SEKCVKEGVTNPSNSSQ--QALLKADYKALKNGVPSPIMATKI----------PKKVIAPVDTGD 73

  Fly   191 IEEDQEETSEDDAECGINMPASKLKITYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVH 255
            :|..:.:.........||:...|.           :.:|:...:.||.|| ||:..:.|.||...
Human    74 LEAGRRKRRRKRRSLAINLTNCKY-----------ESVRRAAQMCGLKEV-GEDEEWTLYWTDCA 126

  Fly   256 MKLDIVRNLAPYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKHFDIVPQTFVLPIESRDLVVA 320
            :.|:.|.::..:|::||||...|:.|||.|.:|:.||..|. ...::|.|:|:.||.:..|. .:
Human   127 VSLERVMDMKRFQKINHFPGMTEICRKDLLARNLNRMYKLY-PSEYNIFPRTWCLPADYGDF-QS 189

  Fly   321 HNKHR--GPWIVKPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTS 383
            :.:.|  ..:|.||.:..:||||||..:|.:|...|..:..:||..||.|||.|.|:|||||:||
Human   190 YGRQRKARTYICKPDSGCQGRGIFITRNPREIKPGEHMICQQYISKPLLIDGFKFDMRVYVLITS 254

  Fly   384 FDPLIIYLYEEGIVRLATVKY-DRHADNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDVGHKWTL 447
            .|||.|:.||||:.|.||..| :...:||.|.||||.||:|||::.:::|     |..||.|..|
Human   255 CDPLRIFTYEEGLARFATTPYMEPSHNNLDNVCMHLTNYAINKHNENFVR-----DGAVGSKRKL 314

  Fly   448 SALLRHLKLQSCDTRQLMLNIEDLIIKAVLACAQSII----SACRMFVPNGNN--CFELYGFDIL 506
            |.|...|:..|.:..:|..:|||:|||.::: |.|::    ..|.....||..  |||:.|||||
Human   315 STLNIWLQEHSYNPGELWGDIEDIIIKTIIS-AHSVLRHNYRTCFPQYLNGGTCACFEILGFDIL 378

  Fly   507 IDNALKPWLLEINLSPSMGVDSPLDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQKWSRFRSSSC 571
            :|:.|||||||:|.|||...||.||.:||..|:.|.:|.|.:...........|::..:.|...|
Human   379 LDHKLKPWLLEVNHSPSFTTDSCLDQEVKDALLCDAMTLVNLRGCDKRKVMEEDKRRVKERLFQC 443

  Fly   572 QRIATFPSTSQKTKKSKKKGAAINLNLTGEEQRILRNARLQYSRRGGFVRIFPTDDSMQRYGNFL 636
            .|   .|..|:|.|......|            :|...|.:.|..|.:.||:|..|: ::|..|.
Human   444 YR---QPRESRKEKTESSHVA------------MLDQERYEDSHLGKYRRIYPGPDT-EKYARFF 492

  Fly   637 DSANGIPISTPNVQSQTFQTPIIQHNYNQML-------HQNLYSKDGRQKQDDNNEADRIWQYER 694
             ..||      ::..:|..:...:....|.|       .|...|...|||..|.|:.:...:..|
Human   493 -KHNG------SLFQETAASKAREECARQQLEEIRLKQEQQETSGTKRQKARDQNQGESAGEKSR 550

  Fly   695 ---ALETDSEIPFVKKPTVEKCEVEGRRLRKIMLKKISNGSELTPFQA---RQTF--SMYLESVL 751
               .|::.|.....:....|| |:...:|..:..::|....||...:|   |:|.  |:.:...|
Human   551 PRAGLQSLSTHLAYRNRNWEK-ELLPGQLDTMRPQEIVEEEELERMKALLQRETLIRSLGIVEQL 614

  Fly   752 RRLTEDPKDNHEKIILKFLNKFGGSVKPPVMFRNMQTIKVASKARSAMVAKLLGDFLENYKRDTE 816
            .||........:|:.......|..:.:|..:.....::|.|.:.
Human   615 TRLQHPGPQGQKKLHESRPKNFNWTGEPAAINSCSLSMKKAGRC--------------------- 658

  Fly   817 AYVDSFDHFGMIPSSAYNQFLMHAQES-DLEAVLTLHTNVTGIMPFLYNR--CGLSVPPTPPIPS 878
                   :|    |||..:.....|.| .|||:               ||  .| |||||.....
Human   659 -------YF----SSARIRLTSQGQASRRLEAI---------------NRVLAG-SVPPTLTPKQ 696

  Fly   879 GLHGFLR------------ALPSMVSS 893
            |.  ||:            .|||||:|
Human   697 GY--FLQPERVASDSWTECTLPSMVNS 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	125/291 (43%)
TTLL13	NP_001382946.1	TTL	133..427	CDD:397308	125/301 (42%)
		HEC1	<425..615	CDD:444066	45/213 (21%)