DRSC/TRiP Functional Genomics Resources

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Protein Alignment TTLL5 and TTLL6

DIOPT Version :10

Sequence 1:NP_733081.1 Gene:TTLL5 / 43015 FlyBaseID:FBgn0051108 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_001124390.1 Gene:TTLL6 / 284076 HGNCID:26664 Length:891 Species:Homo sapiens


Alignment Length:871 Identity:223/871 - (25%)
Similarity:347/871 - (39%) Gaps:210/871 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 SSEGEEPANSSENKSRVLKTSQNAINIKLATDLSNESGYESIAPAKTISNTEVIEEDQEETSEDD 202
            |.|||    :||.|.                |.|.|.      |.:|::...|.|....:....:
Human    57 SQEGE----NSEEKG----------------DSSKED------PKETVALAFVRENPGAQNGLQN 95

  Fly   203 AECGINMPASKLKITYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVHMKLDIVRNLAPY 267
            |:........|.::.........:.:|:....:|..| .||::::.|.||...:.|:.|..:..|
Human    96 AQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFRE-GGEDDDWTLYWTDYSVSLERVMEMKSY 159

  Fly   268 QRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKHFDIVPQTFVLPIESRDL-VVAHNKHRGPWIVK 331
            |::||||...|:.|||.|.:|:.||..: ..|.|...|:|:.||.:..|| ..:.::....:|.|
Human   160 QKINHFPGMSEICRKDLLARNMSRMLKM-FPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICK 223

  Fly   332 PAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEGI 396
            |.:..:|:||||..:..:|...|..:...||..|..|||.|.|||:||||||.|||.|::|.||:
Human   224 PDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGL 288

  Fly   397 VRLATVKYDRH-ADNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDVGHKWTLSALLRHLKLQSCD 460
            .|.||..|.|. .|||.:.||||.||||||:.|::.|     |...|.|..||....:|:..|.:
Human   289 ARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSR-----DAHSGSKRKLSTFSAYLEDHSYN 348

  Fly   461 TRQLMLNIEDLIIKAVLACAQSIISACRMFVPN---GNNCFELYGFDILIDNALKPWLLEINLSP 522
            ..|:..:|||:|||.:::....|........||   .:.|||:.|||||:|:.|||||||:|.||
Human   349 VEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSP 413

  Fly   523 SMGVDSPLDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQKWSRFRSSSCQRIATFPSTSQKTKKS 587
            |...||.||.:||..|:.|.|..:.:.:...:.....:::..:|....|         |::.:..
Human   414 SFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCC---------SREMRIE 469

  Fly   588 KKKG-AAINLNLTGEEQRILRNARLQYSRRGGFVRIFPTDDSMQRYGNFLDSANGIPISTPNVQS 651
            :.|| .|:.|..|...::         ...|||..|:|:.:| ::|..|....|.:         
Human   470 EAKGFRAVQLKKTETYEK---------ENCGGFRLIYPSLNS-EKYEKFFQDNNSL--------- 515

  Fly   652 QTFQTPI---IQHNYNQMLHQNLYSK-------------------------------DGRQKQDD 682
              ||..:   .:..|.:.|.|.|..|                               ..:|:|.|
Human   516 --FQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKD 578

  Fly   683 NNEADRIWQY-------------------ERALETDSEI--------------------PFVKKP 708
            ........||                   ||..||||.:                    ||...|
Human   579 KAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLP 643

  Fly   709 TVEKCEVEGRRLR----KIMLKKISNGSELTPFQARQTFSMYLESV------LRRLTEDPKDNHE 763
            .:....:...:|.    ...:|:..:.|.:..|    |.:::|.||      ..:|:..||    
Human   644 DLRNINLSSSKLEPSKPNFSIKEAKSASAVNVF----TGTVHLTSVETTPESTTQLSISPK---- 700

  Fly   764 KIILKFLNKFGGSVKPPVM-------FRNMQTIKVAS-KARSAMV------AKLLGDFLENYKRD 814
                          .||.:       :...:|.:|.| |.:....      .|:|..||....:.
Human   701 --------------SPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKS 751

  Fly   815 TEAYVDSFDHFGMIPSSAYNQFLMHAQESDLEAVLTLHTNVTGIMPFL---YN-RCGL-SVPPTP 874
                      |...|::.:........:..|.:.|.....::|.:.|.   || :.|: ::...|
Human   752 ----------FWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNP 806

  Fly   875 PIPSGLHGFLRALPSMVSSTGINREL 900
            .:|...|       |...|:|..|:|
Human   807 SLPGECH-------SRSDSSGEKRQL 825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TTLL5NP_733081.1 TTL 266..549 CDD:397308 121/287 (42%)
TTLL6NP_001124390.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..106 15/74 (20%)
TTL 154..441 CDD:397308 121/292 (41%)
c-MTBD region. /evidence=ECO:0000269|PubMed:25959773 420..499 19/96 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..584 3/37 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..636 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..711 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..820 5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

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