Protein Alignment TTLL5 and Ttll6

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_766387.2
• Gene: Ttll6 / 237930
• MGIID: 2683461
• Length: 822
• Species: Mus musculus
• Alignment Length: 780
• Identity: 203/780 - (26%)
• Similarity: 324/780 - (41%)
• Gaps: 147/780 - (18%)

  Fly   137 ISSEGEEPANSSENKSRVLKTSQNAINIKLATDLSNESGYESIAPAKTISNTEVIEEDQEETSED 201
            ::||.||.|...|                       ||..|.:...|.......:.|:.::..::
Mouse     5 LTSESEEGAEERE-----------------------ESSTEDLEELKEFVTLAFVRENTQKRLQN 46

  Fly   202 DAECGINMPASKLKITYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVHMKLDIVRNLAP 266
            ..:.| .....|.::...........:|:....:||.|. |:|:::.|.||...:.|:.|..:..
Mouse    47 AQQHG-KKKRKKKRLVINLSNCRYDSVRRAAQQYGLREA-GDNDDWTLYWTDYSVSLERVMEMKS 109

  Fly   267 YQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKHFDIVPQTFVLPIESRDL-VVAHNKHRGPWIV 330
            ||::||||...|:.|||.|.:|:.||..| ..|.|...|:|:.||.:..|| ..:..:....:|.
Mouse   110 YQKINHFPGMSEICRKDLLARNMSRMLKL-FPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYIC 173

  Fly   331 KPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEG 395
            ||.:..:||||||..|..:|...|..:...||..|..|||.|.||||||||||.|||.:::|.||
Mouse   174 KPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEG 238

  Fly   396 IVRLATVKYDR-HADNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDVGHKWTLSALLRHLKLQSC 459
            :.|.||..|.. :.|||...||||.||||||:.|:::     ||...|.|..||....::|....
Mouse   239 LARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFV-----QDAFSGSKRKLSTFNSYMKTHGY 298

  Fly   460 DTRQLMLNIEDLIIKAVLACAQSIISACRMFVPN---GNNCFELYGFDILIDNALKPWLLEINLS 521
            |..|:...|||:|||.:::....|........|:   .:.|||:.|||||:|..|||||||:|.|
Mouse   299 DVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHS 363

  Fly   522 PSMGVDSPLDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQKWSRF------RSSSCQRIATFPST 580
            ||...||.||.:||..|:.|.|..:.:.....:.....:::..||      |....:.:..|.:.
Mouse   364 PSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAM 428

  Fly   581 S-QKTKKSKKKGAAINLNLTGEEQRILRNARLQYSRRGGFVRIFPTDDSMQRYGNFLDSANGIPI 644
            . |||::.:||..                        |||..|:| ..::::|..|....:.:..
Mouse   429 RLQKTEEYEKKNC------------------------GGFRLIYP-GLNLEKYDKFFQDNSSLFQ 468

  Fly   645 STPNVQSQTFQTPIIQHNYNQMLHQNLYSKDGRQKQDDNNEA-----DRIWQYERALETDSEIPF 704
            :|...:::......:.....|...:.::.|..|:::.....|     |::.:.:|..:..
Mouse   469 NTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQP----- 528

  Fly   705 VKKPTVEKCEVEGRRLRKIMLKKISNGSELTPFQARQTFSMYLESVLRRLTE-------DPKDNH 762
             |..||..|..: :.|..:.|...::|..|.               :|.|.:       :.||..
Mouse   529 -KCKTVATCPPK-QSLHPVTLVSCTSGLLLN---------------IRGLKKGEISESLEQKDTK 576

  Fly   763 EKIILKFLNKFGGSVKPPVMFRNMQTIKVASKAR-----------SAMVAKLLGDFLENYKRDTE 816
            |.:::..         .||..||..::.....|.           :|.|.::...|:.|
Mouse   577 EAMLIPC---------KPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVN------ 626

  Fly   817 AYVDSFDHFGMIPSSAYNQFLMHAQESDLEAVLTLHTNVTGIMPFLYNRCGLSVPPTPPIPSGLH 881
                       |.|:|..   :.:.||..:|...:.|::..:...     .||..|....|..:|
Mouse   627 -----------IESTAQP---ITSVESSRDATAPISTSLESLASM-----SLSTSPECSSPESVH 672

  Fly   882  881
            Mouse   673  672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	122/287 (43%)
Ttll6	NP_766387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		9/41 (22%)
		TTL	105..385	CDD:397308	121/285 (42%)
		c-MTBD region. /evidence=ECO:0000250|UniProtKB:Q8N841	371..450		21/103 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..772
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..822