Protein Alignment TTLL5 and TTLL5

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_055887.3
• Gene: TTLL5 / 23093
• HGNCID: 19963
• Length: 1281
• Species: Homo sapiens
• Alignment Length: 821
• Identity: 282/821 - (34%)
• Similarity: 433/821 - (52%)
• Gaps: 161/821 - (19%)

  Fly   179 IAPAKTISNTEVIEEDQEETSEDDAEC-------------------------GINMPASKLKITY 218
            |..|:.:..|....||:|..|::|..|                         .|.:...:..::|
Human     3 IVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSY 67

  Fly   219 KFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVHMKLDIVRNLAPYQRVNHFPRSYEMTRKD 283
            |..:|:::|:|.:...||..||...:.::||:|||.|:|..::|.|:..|:|||||||||:||||
Human    68 KIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKD 132

  Fly   284 RLYKNIERMQHLRGMKHFDIVPQTFVLPIESRDLVVAHNKHRGPWIVKPAASSRGRGIFIVNSPD 348
            ||||||.||||..|.|.|.|:||||:||.|..:...:::|.||||||||.|||||||::::|:|:
Human   133 RLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPN 197

  Fly   349 QIPQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEGIVRLATVKYDRHADNLWN 413
            ||..:|..:||:||.:||.||..|.|:|:||||||:|||:|||||||:.|.|||:||:.|.|:.|
Human   198 QISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRN 262

  Fly   414 PCMHLCNYSINKYHSDYIRSSDAQDEDVGHKWTLSALLRHLKLQSCDTRQLMLNIEDLIIKAVLA 478
            ..|||.|||:||...||:...|.:.||.|:||::||:||:||.:..||..||.::||||||.:::
Human   263 QFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIIS 327

  Fly   479 CAQSIISACRMFVPNGNNCFELYGFDILIDNALKPWLLEINLSPSMGVDSPLDTKVKSCLMADLL 543
            ...:|.:||:.|||:.::||||||||:|||:.|||||||:|||||:..|:|||.|:|:.:::|:.
Human   328 AELAIATACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMF 392

  Fly   544 TCVGIPAYSPEMKSHYDQKWSRFRSS---------SCQRIATFPST------SQKTKKSKKKGAA 593
            |.||.....|..::.....:..|.||         .|:.::...:.      |.:.|...|.|.:
Human   393 TVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKGPGKLGGS 457

  Fly   594 INLNLTGEEQRILRNARLQYSRRGGFVRIFPTDDSMQRYGNFLD------------------SAN 640
            : |.|:.||.::||..:.:..|||||:|||||.::.:.||::|:                  :|:
Human   458 V-LGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTAD 521

  Fly   641 GIPISTPNVQSQTFQTPIIQHNYNQMLHQNLY-----SKDGRQK--------------------- 679
            |.|           :..|...|....||..||     |.:.|::
Human   522 GAP-----------ELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPA 575

  Fly   680 --------------------QDDNNEADR-----IWQYERALETDSEIPFVKKPTVEK------- 712
                                :|:..||.:     ..:..:|..|.|....|:....|.
Human   576 EMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREW 640

  Fly   713 -------CEVEGRRLR-KIMLKKI--SNGSELTPFQARQTFSMYLESVLRRLTED---------- 757
                   |::|.:.|. |..|.:|  .||: |:..|||..||.||:.|..||.:|
Human   641 NNKGGHCCKLETQELEPKFNLMQILQDNGN-LSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASW 704

  Fly   758 --PKDNHEKIILKFLNKFGGSVKPPVMFRNMQTIKVASKARSAMVAKLLGDFLENYKRDTEAY-- 818
              .:|...:::::||.:...:::..:.. .:.:.::|...|..::|..||||:..|.::||..
Human   705 AAKEDEQMELVVRFLKRASNNLQHSLRM-VLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAE 768

  Fly   819 ------VDSFDHFGMIPSSAYNQFLMHAQESDLEAVLTLHT 853
                  |:..:..| :....:.:|:..|.|::||.|||.:|
Human   769 KKSKKKVEEEEEDG-VNMENFQEFIRQASEAELEEVLTFYT 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	163/282 (58%)
TTLL5	NP_055887.3	TTL	117..395	CDD:397308	145/286 (51%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	378..488		32/142 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..614		6/48 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1072..1114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1199..1281