Protein Alignment TTLL5 and TTLL8

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_024307940.1
• Gene: TTLL8 / 164714
• HGNCID: 34000
• Length: 776
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 129/610 - (21%)
• Similarity: 212/610 - (34%)
• Gaps: 234/610 - (38%)

  Fly   122 PFKKILNRYSSSDTSISSEGEEPANSSENKSRVLKTSQNAINIKLATDLSNES----------GY 176
            |.:|.|:..||||    .:|.|.....:..|:.|.:|......|:|..|:.::          |:
Human     3 PERKGLSLASSSD----GDGREENKLKQGISQDLASSSRLDRYKIARQLTEKAIKEKKIFSIYGH 63

  Fly   177 ESIAPA----------------KTISNTEVIEEDQEETSEDDAECGINMPASKLKITYKFHQTET 225
            ..:..|                |.|.:.    ||:.....||. |.            |..:.:.
Human    64 YPVVRAALRRKGWVEKKFHFLPKVIPDV----EDEGARVNDDT-CA------------KVKENQE 111

  Fly   226 KLLRKLFNVHGLTEVQGENNNFNLLWTGVHMKLDIV--RNLAPYQRVNH---------------- 272
            ..|.|..|:|.:.....:|....||||   :|.||:  .:|...|.:||
Human   112 MALEKTDNIHDVMSRLVKNEMPYLLWT---IKRDIIDYHSLTYDQMLNHYAKTASFTTKIGLCVN 173

  Fly   273 ---------------FPRSYEMTRKDRLYKNIERMQH---------------------------- 294
                           |||.|.:..:....:.:|..:.
Human   174 MRSLPWYVPANPDSFFPRCYSLCTESEQQEFLEDFRRTMASSILKWVVSHQSCSRSSRSKPRDQR 238

  Fly   295 --------------------LRGM--KHFDI---VPQTFVLPIESRDL----------------- 317
                                |||:  :..||   |.|.::..:|..|:
Human   239 EEAGSSDLSSRQDAENAEAKLRGLPGQLVDIACKVCQAYLGQLEHEDIDTSADAVEDLTEAEWED 303

  Fly   318 -------------VVAHNKH------------------------RGPWIVKPAASSRGRGIFIVN 345
                         .::::::                        |..||:||||.||||.|..::
Human   304 LTQQYYSLVHGDAFISNSRNYFSQCQALLNRITSVNPQTDIDGLRNIWIIKPAAKSRGRDIVCMD 368

  Fly   346 SPDQI----------PQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEGIVRLA 400
            ..::|          .:|.:.||.|||..||.|...|.|:|.:.|||.::||.|:.|:|..:|.:
Human   369 RVEEILELAAADHPLSRDNKWVVQKYIETPLLICDTKFDIRQWFLVTDWNPLTIWFYKESYLRFS 433

  Fly   401 TVKYDRHADNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDVG--------HKWTLSALLRHLKLQ 457
            |.::.  .|.| :..:||||.::.||..:          |||        :.||.:....:|:
Human   434 TQRFS--LDKL-DSAIHLCNNAVQKYLKN----------DVGRSPLLPAHNMWTSTRFQEYLQ-- 483

  Fly   458 SCDTRQLMLNIEDLII----KAVLACAQSIISACRMFVPNGNNCFELYGFDILIDNALKPWLLEI 518
                ||....:...:|    |..:|.|..:   .:..|....|.|||||.|.::....:|||:||
Human   484 ----RQGRGAVWGSVIYPSMKKAIAHAMKV---AQDHVEPRKNSFELYGADFVLGRDFRPWLIEI 541

  Fly   519 NLSPSMGVDSPLDTKVKSCLMADLL 543
            |.||:|...:|:..::.:.:..|.:
Human   542 NSSPTMHPSTPVTAQLCAQVQEDTI 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	91/438 (21%)
TTLL8	XP_024307940.1	TTL	<348..574	CDD:397308	74/241 (31%)