Protein Alignment TTLL5 and TTLL11

DIOPT Version :10

• Sequence 1: NP_733081.1
• Gene: TTLL5 / 43015
• FlyBaseID: FBgn0051108
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001132914.2
• Gene: TTLL11 / 158135
• HGNCID: 18113
• Length: 710
• Species: Homo sapiens
• Alignment Length: 915
• Identity: 213/915 - (23%)
• Similarity: 331/915 - (36%)
• Gaps: 301/915 - (32%)

  Fly    31 GSREAVLVFRTN---ILNPKIRKTLSEKSSAQVLTDTKDNEEKPVQSPQKLAEEE------PTSS 86
            ||.|:.|..|..   :...|.......:::|:.:.:....:......|:..|.||      |..:
Human     4 GSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQVRVDAGAAGEPECKAGEEQPKVLAPAPA 68

  Fly    87 EPSSKEALSGSTQQKIFLLKKPQQCDKSDKLTFSSPFKKILNRYSSSDTSISSEGEEPANSSENK 151
            :||:.|  .|:||    :|::|     ...|..|.| |.:             :|..|.....:|
Human    69 QPSAAE--EGNTQ----VLQRP-----PPTLPPSKP-KPV-------------QGLCPHGKPRDK 108

  Fly   152 SRVLKTSQNAINIKLATDLSNESGYESIAPAKTISNTEVIEEDQEETSEDDAECGINMPASKLKI 216
            .|..|.|..        ..|.|:|                  .|...:.|.::...::.|.|:.|
Human   109 GRSCKRSSG--------HGSGENG------------------SQRPVTVDSSKARTSLDALKISI 147

  Fly   217 TYKFHQTETKLLRKLFNVHGLTEVQGENNNFNLLWTGVHM-KLDIVRNLAPYQRVNHFPRSYEMT 280
                    .:|..|.|..       |.....::.|.||.. ..||...     :||.||...||.
Human   148 --------RQLKWKEFPF-------GRRLPCDIYWHGVSFHDNDIFSG-----QVNKFPGMTEMV 192

  Fly   281 RKDRLYKNIERMQHLRGMKHFDIVPQTFVLPIESRDLV--VAHNKHRGP-W----IVKPAASSRG 338
            ||..|.:.:..||:| ..:.::..|::::||.|.:..|  |...|...| |    ||||....:|
Human   193 RKITLSRAVRTMQNL-FPEEYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQG 256

  Fly   339 RGIFIVNSPDQIP-----QDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEGIVR 398
            .||:::..|..|.     |...|||.:||..||.||..|.|:|:|||:.|.|||.||:.::|:.|
Human   257 DGIYLIKDPSDIRLAGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSR 321

  Fly   399 LATVKYDRHA-DNLWNPCMHLCNYSINKYHSDYIRSSDAQDEDVGHKWTLSALLRHLKLQSCDTR 462
            ..|..|.... .||....|||.|||:|.:..::|.|..|   ..|.|.|.|::|..|..:..|.:
Human   322 FCTEPYQEPTPKNLHRIFMHLTNYSLNIHSGNFIHSDSA---STGSKRTFSSILCRLSSKGVDIK 383

  Fly   463 QLMLNIEDLIIKAVLACAQSIISACRMFVPNGN---NCFELYGFDILIDNALKPWLLEINLSPSM 524
            ::..:|..::||.|:|....:....:..:|.|.   .||::.|||||:...|||.|||:|.:|||
Human   384 KVWSDIISVVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPILLEVNANPSM 448

  Fly   525 GVD-----SP---------LDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQKWSRFRSSSCQRIA 575
            .::     ||         :|.:||..::.|.|..:     .|..|...:|
Human   449 RIEHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLM-----DPLKKKRENQ-------------- 494

  Fly   576 TFPSTSQKTKKSKKKGAAINLNLTGEEQRILRNARLQYSRRGGFVRIFPTDDSMQRYGNFLDSAN 640
                 ||:.:|.          ..|:|                                  |:.:
Human   495 -----SQQLEKP----------FAGKE----------------------------------DALD 510

  Fly   641 GIPISTPNVQSQTFQTPIIQHNYNQMLHQNLYSKDGRQKQDDNNEADRIWQYERALETDSEIPFV 705
            |...|.|:..:                               |.||
Human   511 GELTSAPDCNA-------------------------------NPEA------------------- 525

  Fly   706 KKPTVEKCEVEGRRLRKIMLKKISNGSELTPFQARQTFSMYLESVLRRLTEDPKDNHEKIILKFL 770
                         .|..|.||::      .|..|:| |: ||..|         |....:.::||
Human   526 -------------HLPSICLKQV------FPKYAKQ-FN-YLRLV---------DRMANLFIRFL 560

  Fly   771 NKFGGSVKPPVMFRN-MQTIKVASKARS-AMVAKLLGDFLENY------KRDT----EAYVDSF- 822
            ...|.....|..||. :::.|::|.:.| |.|..|..|....:      :||:    :|:|::|
Human   561 GIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFF 625

  Fly   823 ----DHFGMIPSSAYNQFLMHAQESDLEAVLTLHTNVTGIMPFLYNRCGLSV----------PPT 873
                ..|.|:|        :|.|.:.|..:...|.::......:   ||..|          ||.
Human   626 FLAQRKFKMLP--------LHEQVASLIDLCEYHLSLLDEKRLV---CGRGVPSGGRPPHRGPPQ 679

  Fly   874 PPIPS 878
            .|.||
Human   680 EPSPS 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL5	NP_733081.1	TTL	266..549	CDD:397308	106/312 (34%)
TTLL11	NP_001132914.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	41..135		28/144 (19%)
		CPSase_L_D2	181..482	CDD:473076	105/304 (35%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	467..538		24/207 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..710		6/20 (30%)