Protein Alignment Nepl16 and ECE2

DIOPT Version :10

• Sequence 1: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 799
• Identity: 159/799 - (19%)
• Similarity: 269/799 - (33%)
• Gaps: 245/799 - (30%)

  Fly   104 KMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQ 168
            ::.:..|:||:..||:...:...:.....|....|..:.                 |..||..|.
Human   106 ELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEA-----------------CIRVAGKIL 153

  Fly   169 ARLNWNKDPCTEFKKFSC--W-RNTPNKNITNLIEMGNSQKSVDSQML-YLFQNKIMNGSFGI-- 227
            ..|:....||.:|.:|||  | |..|..:..:.....||....:..:| :|.:|...|.|...
Human   154 ESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQ 218

  Fly   228 -LHNLFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIYDLGPSPLVDLYHDL--- 288
             ....:.||||                                :.:|.:||..||.||...:
Human   219 KTQRFYLSCLQ--------------------------------VERIEELGAQPLRDLIEKIGGW 251

  Fly   289 --------------------SYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQGVPKL 333
                                :|...|...:.||..|.||.               |.:.|
Human   252 NITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSN---------------SNVIQ----- 296

  Fly   334 LADLIENFLPYFVSYAQRVSEKDTI---FEFIKDLNKL-------------QV------------ 370
             .|....|||....|..|.:.:..:   .:::::|..|             ||
Human   297 -VDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITV 360

  Fly   371 -EHSRRGFWDSTVLY---NVSSLQDLYPVLNWT-----LLIPQNWSG--PIVVRNSDYLKALEYF 424
             :..||   |...:|   ::|.||.|.|.::|.     ||.|...|.  |:||...|||:.:...
Human   361 PQDQRR---DEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSEL 422

  Fly   425 LTKYPTRVAHNSL---LLLSALQILPRDY-------------------PSPEVCTRSTMWALPEL 467
            :.:....:.:|.|   |:......|.|.:                   |..:.|..:|..||...
Human   423 INRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFA 487

  Fly   468 SSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKRA--------PSLKGAALVKLSAL-------- 516
            ..||::........|:.   ||.:...::...:.|        ...:.||..|..|:
Human   488 LGSLFVKATFDRQSKEI---AEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPD 549

  Fly   517 -----KIQSQTWEGFSNTTDLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGGSHDAWAY 576
                 |.....::|:             .|:.:.:|||:|.:|..:.....|......|.|.|:.
Human   550 FILEPKELDDVYDGY-------------EISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSM 601

  Fly   577 -PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDEK----- 635
             |.....:|....:.||.|..::..|::....|..|::..:||.:..|    :|.:||::
Human   602 TPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHE----LTHAFDDQGREYD 662

  Fly   636 ---------------AMR----CVPHSVNIFS-NYSRM-------DILIHSGGMQISYHSMLSLT 673
                           |.|    |:....|.:. |..|:       :.:..:||::.:|::..:..
Human   663 KEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWL 727

  Fly   674 GPIKGMARLPGLNLTPTQIFFLVSAQELCA----ESNYLGI--DTNAPEFDNILGWLVAQGGSAT 732
            .......:||.:.||..|:||:..||..|:    ||::.|:  |.::|....:||.| :......
Human   728 RKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTL-SNSRDFL 791

  Fly   733 EVFKCPSGSMINVQKTCNV 751
            ..|.||.||.:|..:.|.|
Human   792 RHFGCPVGSPMNPGQLCEV 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	145/724 (20%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	145/725 (20%)