DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl16 and Ece1

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	846	Identity:	169/846 - (19%)
Similarity:	292/846 - (34%)	Gaps:	259/846 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DEIEMIDS-------ANIENFNTRYNKNSIIGWICCAPCIWLRTSAAVHKMAITSATLLVTTL-- 117
            ||.:::||       .|....|.|..::   |..|.|    .|||  |.|..:...|||...|
  Rat    26 DEEDLVDSLSEGDVYPNGLQVNFRSPRS---GQRCWA----ARTS--VEKRLVVLVTLLAAGLVA 81

  Fly   118 -LVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQARLNWNKDPCTEF 181
             |.|..|.:...|                      ||.|....|.:|.|||...::...|||.:|
  Rat    82 CLAALGIQYRTRT----------------------PPVCLTEACVSVTSSILNSMDPTVDPCQDF 124

  Fly   182 KKFSC--WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGSFGILHNLFESCLQQTTNSTV 244
            ..::|  |..      .|.:..|:|:                   :|...||:|.      |..:
  Rat   125 FSYACGGWIK------ANPVPDGHSR-------------------WGTFSNLWEH------NQAI 158

  Fly   245 MHRIFDSLGGYLPVGSVGPSSIAPLIAKIY-----------DLGPSPLVDLYHDLS--------- 289
            :..:.::        |...:|.|...|::|           :|...||::|...|.
  Rat   159 IKHLLEN--------STASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWA 215

  Fly   290 --------------YGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQ------GVP--- 331
                          |...|...:.:|..|.:|.               |.:.|      |:|
  Rat   216 KDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN---------------SNVIQVDQSGLGLPSRD 265

  Fly   332 ---------KLLADLIENFLPYFVSYAQRVSEKD---------TIFEFIKDLNKLQVEHSRRGFW 378
                     |:|.    .:|.|.|...:.:...|         .|.:|...|..:.:...:|.
  Rat   266 YYLNKTENEKVLT----GYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRR-- 324

  Fly   379 DSTVLYN---VSSLQDLYPVLNW-----TLLIPQ--NWSGPIVVRNSDYLKALEYFLTKYPTRVA 433
            |..::|:   .:.||.|.|.:||     .:..|.  |.|.||||.:.:||:.:...:......:.
  Rat   325 DEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLL 389

  Fly   434 HNSL---LLLSALQILPRDY-------------------PSPEVCTRSTMWALPELSSSLYIAQH 476
            :|.:   |:......|.:.:                   |..:.|...|...|......:::...
  Rat   390 NNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKAT 454

  Fly   477 SSEDLKDTTKRAEIIFKSLKAHLKRAPSLK-------GAALVKLSALKIQSQTWEGFSN----TT 530
            .:||.|:..  :|||.:..||..:...:||       .:|..|..|:    ....|:.|    ..
  Rat   455 FAEDSKNIA--SEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAI----YNMIGYPNFIMDPK 513

  Fly   531 DLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGGSHDAWAY--PIVSTIFYDTLSHSIVV 593
            :|.|.........:.:|:|.:..:..:.....|......:.|.|:.  |:|:. :|....:.||.
  Rat   514 ELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNA-YYSPTKNEIVF 577

  Fly   594 PLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITKSFDEKA---------------------- 636
            |..::..|::....|..|::..:||.:..|    :|.:||::.
  Rat   578 PAGILQAPFYTRSSPNALNFGGIGVVVGHE----LTHAFDDQGREYDKDGNLRPWWKNSSVEAFK 638

  Fly   637 --MRCVPHSVNIFS--------NYSRMDILIHSGGMQISYHSMLSLTGPIKGMARLPGLNLTPTQ 691
              ..|:....|.:|        .::..:.:..:||::.:|.:..:..........||.|.||..|
  Rat   639 QQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQ 703

  Fly   692 IFFLVSAQELCA----ESNYLGI--DTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCN 750
            :|||..||..|:    ||::.|:  |.::|....::|.| :.....:|.|:||.||.:|.:..|.
  Rat   704 LFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL-SNSKEFSEHFRCPLGSPMNPRHKCE 767

  Fly   751 V 751
            |
  Rat   768 V 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	136/718 (19%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	142/736 (19%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	136/720 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910