DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl16 and MMEL1

DIOPT Version :9

Sequence 1:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	820	Identity:	175/820 - (21%)
Similarity:	287/820 - (35%)	Gaps:	255/820 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LLVTTLLVASPILFLI---STAPSPLPRDCYMDGDR---------CSPAVSAPPECSDPICEAVA 164
            ||||..|||..:|:..   ...|....|.|::..:|         ...|......|:.|.|...|
Human    34 LLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAA 98

  Fly   165 SSIQARLNWNKDPCTEFKKFSC--WRNTPNKNITNLIEMGNSQKSVDSQM---LYLFQNKIMNGS 224
            :.|...::...:||.:|.:|:|  |..      .::|...||:.|:...:   |.:....::..|
Human    99 ARILQNMDPTTEPCDDFYQFACGGWLR------RHVIPETNSRYSIFDVLRDELEVILKAVLENS 157

  Fly   225 FG-------ILHNLFESCLQQTT----NSTVMHRIFDSLGGYLPVG------SVG-----PSSIA 267
            ..       ....|:.||:.|:.    .|..:..|.:.:||: ||.      :||     ...:|
Human   158 TAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGW-PVAMDRWNETVGLEWELERQLA 221

  Fly   268 PLIAKIYDLGPSPLVDLY---HDLSYGRRPHILLI----ISGPSTSSTI---LERKIRWMSPKAP 322
            .:.::   .....|:||:   .|.:..|  ||:.|    :..||.....   ..||:|
Human   222 LMNSQ---FNRRVLIDLFIWNDDQNSSR--HIIYIDQPTLGMPSREYYFNGGSNRKVR------- 274

  Fly   323 PSRIRQGVPKLLADLIENFLPYFVSYAQRVSE-----KDT---------IFEFIKDLNKLQVEHS 373
                            |.:|.:.||.|..:.|     :|:         :.|....|.|..|...
Human   275 ----------------EAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQE 323

  Fly   374 RRGFWDSTVLYNVSSLQDLYPV-----LNWTLLIPQNWSG---------PIVVRNSDYLKALEYF 424
            .|  .|...||:...|::|...     .||||.|....|.         .:||....||:.||..
Human   324 ER--HDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENI 386

  Fly   425 LTKYPTRVAHNSL---LLLSALQILPRDYPSPEVCTRSTMWA------------------LPELS 468
            :..|..|...|.|   |:|..:..|.:.:....|..|..::.                  :....
Human   387 IDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAV 451

  Fly   469 SSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKRAPSL-------KGAALVKLSALKIQSQTW--- 523
            .|||:.:....|.|...:  |:|.|.....::....|       |..|..|  |:.|:.|..
Human   452 GSLYVREAFPGDSKSMVR--ELIDKVRTVFVETLDELGWMDEESKKKAQEK--AMSIREQIGHPD 512

  Fly   524 -----------EGFSNTTDLLKSLQPLNITSECWFQNILEIYK----------KNKLEPNDISLN 567
                       |.:||          ||.:.:.:|:|.|:..|          :.|::||
Human   513 YILEEMNRRLDEEYSN----------LNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPN----- 562

  Fly   568 GGSHDAWAY-PIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSI--- 628
                 .|.. ..|...||....:.||.|..::..|:|:...|..|::..:|:.|..||....
Human   563 -----LWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDN 622

  Fly   629 ------------------TKSFDEKAMRCVPHSVNIFSNYSRMDI---------------LIHSG 660
                              |:.|.|:: .|:.:.   :.||| .|:               :..:|
Human   623 GRNFDKNGNMMDWWSNFSTQHFREQS-ECMIYQ---YGNYS-WDLADEQNVNGFNTLGENIADNG 682

  Fly   661 GMQISYHSMLSLTGPIKGMA------RLPGLNLTPTQIFFLVSAQELCAESNY--------LGID 711
            |::.:|.:.|      |.||      :||||:||..|:||:..||..|  .:|        :..|
Human   683 GVRQAYKAYL------KWMAEGGKDQQLPGLDLTHEQLFFINYAQVWC--GSYRPEFAIQSIKTD 739

  Fly   712 TNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKTCNV 751
            .::|....:||.|......| :.|.|..|:.::.::.|.|
Human   740 VHSPLKYRVLGSLQNLAAFA-DTFHCARGTPMHPKERCRV 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	155/740 (21%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	157/752 (21%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	155/740 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910